Highlights
- •Cancer patients with COVID-19 have a higher morbidity and mortality.
- •Particularly patients with ongoing or recent cancer treatment, metastatic solid tumors and hematological malignancies are at risk.
- •Underlying immunosuppression, elevated cytokine levels, altered expression of the angiotensin converting enzyme (ACE-2) and TMPRSS2, and a prothrombotic status in cancer patients may fuel the effects of a SARS-CoV-2 sepsis.
- •The gene expression level of ACE2 may be an indicator of the susceptibility to SARS-CoV-2 infection, while TMPRSS2 plays a supporting role.
- •Better knowledge of the mechanisms involved may be a tool to identify high risk patients and to prevent severe complications by targeting the involved pathways.
Abstract
Keywords
Introduction
- Mousavizadeh L.
- Ghasemi S.
- Mousavizadeh L.
- Ghasemi S.
Lavezzo E, Franchin E, Ciavarella C, Cuomo-Dannenburg G, Barzon L, Del C, et al. Suppression of COVID-19 outbreak in the municipality of Vo, Italy. https://doi.org/10.1101/2020.04.17.20053157.
Adams ER, Ainsworth M, Anand R, Andersson MI, Auckland K, Baillie JK, et al. Antibody testing foor COVID-19: A report from the National COVID Scientific Advisory Panel. doi: https://doi.org/10.1101/2020.04.15.20066407.
- Qu R.
- Ling Y.
- Zhang Y.H.
- Wei L.Y.
- Chen X.
- Li X.M.
- et al.
COVID-19 and cancer
Susceptibility of cancer patients for SARS-CoV-2 infection
- Yu J.
- Ouyang W.
- Chua M.L.K.
- Xie C.
Morbidity and mortality in cancer patients with COVID19
Williamson E, Walker AJ, Bhaskaran KJ, Bacon S, Bates C, Morton CE, et al. OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million NHS patients. doi: https://doi.org/10.1101/2020.05.06.20092999.

- Ouyang Y.
- Yin J.
- Wang W.
- Shi H.
- Shi Y.
- Xu B.
- et al.
COVID-19 and delay of cancer care
- Arduino P.G.
- Conrotto D.
- Broccoletti R.
- Peeters M.
- van Dam P.
- Rasschaert M.A.
- Vulsteke C.
- De Keersmaecker S.
- Croes L.
- et al.
Potential biomarkers to identify high risk patients and targets for treatment
The angiotensin converting enzyme receptor and TMPRSS2
Losartan for Patients with COVID-19 Requiring Hospitalisation - ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04312009.
- Corley M.J.
- Ndhlovu L.C.D.N.A.

Cytokine signaling
Coomes AE, Haghbayan H. Interleukin-6 in COVID-19: a systematic review and meta-analysis. doi: https://doi.org/10.1101/2020.03.30.20048058.
- Stoll J.R.
- Vaidya T.S.
- Mori S.
- Dusza S.W.
- Lacouture M.E.
- Markova A.
- Ascierto P.A.
- Fox B.
- Urba W.
- Anderson A.C.
- Atkins M.B.
- Borden E.C.
- et al.
- Liu B.
- Li M.
- Zhou Z.
- Guan X.
- Xiang Y.
- Richardson P.J.
- Corbellino M.
- Stebbing J.
- Barnes B.J.
- Adrover J.M.
- Baxter-Stoltzfus A.
- Borczuk A.
- Cools-Lartigue J.
- Crawford J.M.
- et al.
Coagulopathy
- Wang J.
- Hajizadeh N.
- Moore E.E.
- McIntyre R.C.
- Moore P.K.
- Veress L.A.
- et al.
- Wang J.
- Hajizadeh N.
- Moore E.E.
- McIntyre R.C.
- Moore P.K.
- Veress L.A.
- et al.
Conclusion
Acknowledgment
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