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Editorial Board
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IFC
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Mechanism of action of demethylating and immune modulatory agents – Introduction
27 May 2011
For a number of decades, chemotherapy has been the central treatment option for different types of cancer including hematological malignancies. Due to the intensive and continuous work of cooperative ...
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Wolf-K. Hofmann,
Carsten Müller-Tidow
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S1
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Immune modulatory agents in hematopoietic malignancies
06 June 2011
Abstract: Immune modulatory drugs have been successfully used to treat patients with multiple myeloma (MM), myelodysplastic syndromes displaying loss of 5q (del5q MDS) and chronic lymphocytic leukemia...
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Irina Idler,
Nupur Bhattacharya,
Hartmut Döhner,
Stephan Stilgenbauer,
Daniel Mertens
et al.
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S2-S7
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Transcriptional regulation by DNA methylation
25 May 2011
Abstract: Epigenetic mechanisms synergize with genetic alterations in modulating gene expression patterns in cancer cells. While epigenetic alterations are reversible genetic modifications are not. Th...
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Anna R. Poetsch,
Christoph Plass
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S8-S12
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DNA methylation as a pathogenic event and as a therapeutic target in AML
26 May 2011
Abstract: DNA methylation and its influence on gene expression are key in understanding cancer pathogenesis. Even though it is becoming clear that DNA methylation strongly interacts with other compone...
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Till Schoofs,
Carsten Müller-Tidow
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S13-S18
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Mechanism of action of demethylating and immune modulatory agents – Discussion
30 May 2011
Treatment with demethylating agents as well as with immune modulatory substances has significantly contributed to the therapeutic spectrum available for patients with either hematological malignancies...
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Wolf-K. Hofmann
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S19-S22
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Mechanism of action of demethylating and immune modulatory agents – Conclusion
26 May 2011
Significant progress has been made in recent years in the understanding of myelodysplastic syndromes and acute myeloid leukemia. Classification is increasingly based on molecular aberrations that driv...
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Carsten Müller-Tidow,
Wolf-K. Hofmann
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S23-S24
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