« Previous
Next »
Cancer Treatment Reviews
Volume 24, Issue 4
, Pages 265-281
, August 1998
Cumulative toxicities from cisplatin therapy and current cytoprotective measures
References
- . Cisplatin. Ann Intern Med. 1984;100:704–713
-
.
Phase I evaluation of cis-platinum (II) diamminedichloride (PDD) and a combination of PDD plus Adriamycin.
In:
Connors TA, Roberts JJ editor. Platinum Coordination Complexes in Cancer Chemotherapy.
Recent Results in Cancer Research. vol 48:New York: Springer; 1994;p. 167–177
-
.
cis-Platinum (II) diamminedichloride: clinical experience of the Royal Marsden Hospital and Institute of Cancer Research, London.
In:
Connors TA, Roberts JJ editor. Platinum Coordination Complexes in Cancer Chemotherapy.
Recent Results in Cancer Research. vol48:New York: Springer; 1974;p. 178–182
- . High dose cis-platinum diammine dichloride: amelioration of renal toxicity by mannitol diuresis. Cancer. 1977;39:1372–1381
- . Cisplatin dose intensity. Semin Oncol. 1989;16(Suppl. 6):22–30
- Randomised study of two doses of cisplatin with cyclophosphamide in epithelial ovarian cancer. Lancet. 1992;340:329–333
- . Total platinum dose versus platinum dose intensificaion in ovarian cancer treatment. Semin Oncol. 1994;21(Suppl. 2):11–15
- . Cisplatin nephrotoxicity: a review. Cancer Chemother Pharmacol. 1989;25:1–9
- . Newer insights into cisplatin nephrotoxicity. Ann Pharmacother. 1993;27:1519–1525
- . Cisplatin neurotoxicity. Cancer Treat Rev. 1989;16:195–211
- . Cisplatin-associated neurotoxicity: can it be prevented?. Anticancer Drugs. 1995;6:369–383
- Protection from nausea and vomiting in cisplatin-treated patients: high-dose metoclopramide combined with methylprednisolone versus metoclopramide combined with dexamethasone and diphenhydramine: a study of the Italian Oncology Group for Clinical Research. J Clin Oncol. 1989;7:1693–1700
- . Recent improvements in antiemetic therapy. Tumori. 1997;83(Suppl. 2):S3–S14
- . Drug treatment of chemotherapyinduced delayed emesis. Drugs. 1996;52:639–648
- . Testicular carcinoma. Postgrad Med j. 1997;73:481–486
- . Optimal number of chemotherapy courses in advanced nonseminomatous testicular carcinoma. Am J Clin Oncol. 1995;18:463–468
- . Meta-analysis of chemotherapy regimens for ovarian carcinoma: a reassessment of cisplatin, cyclophosphamide and doxorubicin versus cisplatin and cyclophosphamide. Eur J Gynaecol Oncol. 1997;18:343–348
- . Combined treatment approaches in regionally advanced bladder cancer. Urol Clin North Am. 1992;19:761–774
-
.
Five-year followup of a prospective trial of radical cystectomy and neoadjuvant chemotherapy: Nordic Cystectomy Trial I: The Nordic Cooperative Bladder Cancer Study Group.
I Urol. 1996;155:1903–1906
- . Current management of small cell lung cancer. Semin Oncol. 1997;24:463–476
- . Clinical practice guidelines for the treatment of unresectable non-small-cell lung cancer: adopted on May 16, 1997 by the American Society of Clinical Oncology. J Clin Oncol. 1997;15:2996–3018
- . Eastern Cooperative Oncology Group experience with chemotherapy in advanced non-small cell lung cancer. Chest. 1998;113(Suppl. 1):13S–16S
-
.
Combined-modality therapy of head and neck cancer.
Oncology (Huntingt). 1997;11(Suppl. 9):27–30
- . Why has induction chemotherapy for advanced head and neck cancer become a United States community standard of practice?. J Clin Oncol. 1997;15:2050–2055
- . Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group J Natl Cancer Inst. 1996;88:890–899
- . Palliative and adjuvant regional chemotherapy in pancreatic cancer. Eur J Surg Oncol. 1997;23:409–414
- Clinical response to systemic combined chemotherapy with 5-fluorouracil and cisplatin (FP therapy) in patients with advanced pancreatic cancer. Jpn J Clin Oncol. 1996;26:215–220
- Phase II trial of paclitaxel and cisplatin in women with advanced breast cancer: an active regimen with limiting neurotoxicity. J Clin Oncol. 1996;14:1993–1999
- A phase II trial of circadiantimed paclitaxel and cisplatin therapy in metastatic breast cancer. Ann Oncol. 1997;8:663–667
- Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup. Lancet. 1997;350:911–917
- . The treatment of metastatic melanoma with chemotherapy and biologics. Curr Opin Oncol. 1997;9:205–213
- Assessment of dose-intensive therapy in suboptimally debulked ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol. 1995;13:1589–1599
- Mature results of a randomized trial of two doses of cisplatin for the treatment of ovarian cancer. J Clin Oncol. 1996;14:2113–2119
- High-dose versus low-dose cisplatin in combination with cyclophosphamide and epidoxorubicin in suboptimal ovarian cancer: a randomized study of the Gruppo Oncologico Nord-Ovest. J Clin Oncol. 1996;14:351–356
- Neurotoxicity in a phase I trial of continuous infusion cisplatin with hyperfractionated radiotherapy for locally advanced head and neck cancer. Head Neck. 1996;18:236–241
- Cisplatin neuropathy. In: Risk factors, prognosis, and protection by WR-2721. Cancer. 61:1988;p. 2192–2195
- Neurotoxicity is not enhanced by increased dose intensities of cisplatin administration. Eur J Cancer. 1995;31A:678–681
- . The long-term effect of cisplatin on renal function. Cancer. 1986;58:2214–2217
- . Renal function related to different treatment modalities for malignant germ cell tumours. Br J Cancer. 1990;62:842–846
- Influence of combination chemotherapy with cis-diamminedichloroplatinum on renal function: long-term effects. Oncology. 1983;40:170–173
- Long-term renal effect of cisplatin in man. Am J Nephrol. 1994;14:81–84
- . Long-term effects of chemotherapy in patients with testicular cancer. J Clin Oncol. 1992;10:574–579
- Definitive end-stage chronic kidney failure after cisplatin treatment. Nephrologie. 1993;14:227–229
- . Acute and chronic effects of cisplatin therapy on renal magnesium homeostasis. Med Pediatr Oncol. 1997;28:35–40
- . Cisplatin-associated hemolytic uremic syndrome. Cancer. 1994;74:3059–3062
- . Effects of cisplatin on different measures of glomerular function in the human kidney with special emphasis on high-dose. Cancer Chemother Pharmacol. 1988;21:163–167
- . Acute and long-term nephrotoxicity of cisplatinum in man. Cancer Chemother Pharmacol. 1986;17:191–196
- . Renal tubular function in patients treated with high-dose cisplatin. Clin Pharmacol Ther. 1988;44:164–172
- . Long term effect of cis-diamminedichloride platinum (CDDP) on renal function and structure in man. Cancer. 1978;41:1274–1281
- . Effect of cisplatin on renal function in rabbits: mechanism of reduced glucose reabsorption. Toxicol Appl Pharmacol. 1995;130:19–26
- . Critical subcellular targets of cisplatin and related platinum analogs in rat renal proximal tubule cells. Kidney Int. 1995;48:761–770
- . Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis in rat kidney cortex: different effects of antioxidants and radical scavengers. Toxicology. 1988;51:119–132
- . Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J Pharmacol Exp Ther. 1997;280:638–649
- . Adverse effects of antitumor drug, cisplatin, on rat kidney mitochondria: disturbances in glutathione peroxidase activity. Biochem Biophys Res Commun. 1989;159:1121–1127
- . Stimulation of the renal endoplamic reticulum calcium pump: a possible biomarker for platinate toxicity. Toxicol Appl Pharmacol. 1988;92:157–169
- . Cumulative renal tubular damage associated with cisplatin nephrotoxicity. Cancer Chemother Pharmacol. 1986;18:69–73
- . Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
- . Clearance of iohexol, 51Cr-EDTA and endogenous creatinine for determination of glomerular filtration rate in pigs with reduced renal function: a comparison between different clearance techniques. Scand J Clin Lab Invest. 1997;57:241–252
- . Conventional measurement of renal function utilizing serum creatinine, creatinine clearance, inulin and paraaminohippuric acid clearance. Curr Opin Nephrol Hypertens. 1995;4:505–509
- . Creatinine clearance predicted from body cell mass is a good indicator of renal function. Kidney Int Suppl. 1997;63:S166–S168
- The clinical significance of calculated versus measured creatinine clearance in patients with gynecologic malignancy. South Med J. 1996;89:967–970
- . Urinary excretion of beta 2-microglobulin and N-acetyl-beta-d-glucosaminidase in advanced neuroblastoma patients receiving cis-diamminedichloroplatinum(II). Eur J Surg Oncol. 1988;14:17–20
- Cisplatin-induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels. Acta Obstet Gynecol Scand. 1997;76:590–595
- . Hypomagnesemia and renal magnesium wasting in patients receiving cisplatin. Ann Intern Med. 1979;90:929–931
- Hypomagnesemia after cisplatin combination chemotherapy. Arch Intern Med. 1984;144:2347–2348
-
.
cis-Diamminedichloroplatinuminduced hypomagnesemia and renal magnesium wasting.
Eur J Cancer. 1985;21:287–290
- Cisplatin nephrotoxicity: symptomatic hypomagnesemia and renal failure. Int J Pediatr Nephrol. 1986;7:151–152
- Renal salt wasting in patients treated with cisplatin. Ann Intern Med. 1988;108:21–25
-
.
Persisting renotubular sequelae after cisplatin in children and adolescents.
Am I Nephrol. 1991;11:127–130
-
.
Renal salt wasting in patients treated with high-dose cisplatin, etoposide, and mitomycin in patients with advanced non-small cell lung cancer.
Korean I Intern Med. 1992;7:118–121
- . Hyponatremia during treatment with cisplatin. Presse Med. 1997;26:1523–1525
-
.
Hypomagnesemia in patients of gynecologic neoplasms following chemotherapy with cisplatin.
Chung Hua Fu Chan Ko Tsa Chih. 1995;30:363–365
- . Persistent hypomagnesemia following cisplatin chemotherapy for testicular cancer. Cancer Treat Rep. 1982;66:1767–1769
- . Hypomagnesemia, renal dysfunction, and Raynaud's phenomenon in patients treated with cisplatin, vinblastine, and bleomycin. Cancer. 1985;56:2765–2770
- Persistent hypomagnesemia following cisplatin chemotherapy in patients with ovarian cancer. J Cancer Res Clin Oncol. 1991;117:89–90
- Carboplatin reinduction after taxane in patients with platinum-refractory epithelial ovarian cancer. J Clin Oncol. 1995;13:1584–1588
- A phase I and pharmacokinetic study of diamminecyclobutane-dicarboxylatoplatinum (NSC 241240). Cancer Res. 1983;43:4470–4473
- Pharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) in patients with normal and impaired renal function. Cancer Res. 1984;44:1693–1697
- Pharmacokinetics and dosage reduction of cis-diammine(1,1-cyclobutanedicarboxylato)platinum in patients with impaired renal function. Cancer Res. 1984;44:5432–5438
- Carboplatin dosage: Prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989;7:1748–1756
- Platinum analogue combination chemotherapy: cisplatin and carboplatin-A phase I trial with pharmacokinetic assessment of the effect of cisplatin administration on carboplatin excretion. J Clin Oncol. 1987;5:1281–1289
- High-dose platinum consisting of combined carboplatin and cisplatin in previously untreated ovarian cancer patients with residual disease. J Clin Oncol. 1989;7:1469–1473
- Relationships between carboplatin exposure and tumor response and toxicity in patients with ovarian cancer. J Clin Oncol. 1992;10:520–528
- Ifosfamide plus cisplatin as primary chemotherapy of advanced ovarian cancer. Gynecol Oncol. 1997;67:168–171
- Ifosfamide and cisplatin as neoadjuvant chemotherapy for advanced cervical carcinoma. Am J Clin Oncol. 1996;19:132–135
- . Cisplatin and ifosfamide in patients with advanced squamous cell carcinoma of the uterine cervix: a phase II trial. Acta Oncol. 1995;34:257–259
- Ifosfamide plus highdose cisplatin in patients with non-small cell lung cancer previously treated with chemotherapy. Am J Clin Oncol. 1995;18:303–306
-
Phase II trial of ifosfamide and cisplatin in the treatment of metastatic sarcomas: a Southwest Oncology Group study.
Cancer Chemother Pharmacol. 1993;31(Suppl. 2):S213–S216
- Ifosfamide, Fanconi s syndrome, and rickets. J Clin Oncol. 1991;9:1495–1499
- Potentiation of ifosfamide neurotoxicity, hematotoxicity, and tubular nephrotoxicity by prior cis-diamminedichloroplatinum(II) therapy. Cancer Res. 1987;47:1457–1460
- Phase I study of high-dose cisplatin, ifosfamide, and etoposide. Cancer Chemother Pharmacol. 1994;34:331–334
- A phase I trial of ifosfamide, mesna, and cisplatin in advanced non-small cell lung cancer. Cancer. 1993;72:62–68
- Ifosfamide in refractory male germ cell tumors. J Clin Oncol. 1986;4:28–34
- Ifosfamide in combination chemotherapy for sarcomas and testicular carcinomas. Cancer Treat Rev. 1983;10:129–135 (Suppl.)
- Long-term followup of a phase III intergroup study of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol. 1997;15:2564–2569
- A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol. 1992;10:1066–1073
- A phase II trial of neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin in the treatment of patients with locally advanced breast carcinoma. Cancer. 1998;82:503–511
- Phase II evaluation of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) in advanced, measurable breast carcinoma. Cancer Invest. 1995;13:150–159
- M-VAC combination in locally advanced, locally recurrent or metastatic breast carcinoma: a phase II study. Ann Oncol. 1994;5:93–94
- . The clinical pharmacology of methotrexate. Cancer. 1978;41:36–51
- Methotrexate, vinblastine, adriamycin and cisplatin (MVAC) chemotherapy for the treatment of advanced bladder carcinoma. Int Urol Nephrol. 1993;25:351–357
- Phase II trial of methotrexate, vinblastine, doxorubicin, and cisplatin in advanced/recurrent endometrial carcinoma. Gynecol Oncol. 1995;58:240–243
- . Methotrexate-related deaths in patients previously treated with cis-diamminedichloride platinum. Cancer Chemother Pharmacol. 1984;13:223–225
- Importance of bleomycin in combination chemotherapy for good-prognosis testicular nonseminoma: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group. J Clin Oncol. 1997;15:1837–1843
- . A prospective study of VEC-POB and POCE chemotherapy in aggressive non-Hodgkin's lymphoma. Am J Clin Oncol. 1997;20:179–183
- . Treatment of men with metastatic non-seminomatous germ cell tumours with cyclical POMB/ACE chemotherapy. Ann Oncol. 1997;8:477–483
- Filgrastim during combination chemotherapy of patients with poor-prognosis metastatic germ cell malignancy: European Organization for Research and Treatment of Cancer, Genito-Urinary Group, and the Medical Research Council Testicular Cancer Working Party, Cambridge, United Kingdom. J Clin Oncol. 1998;16:716–724
- . Bleomycin in nonseminomatous germ-cell tumors: cure rate versus morbidity. J Clin Oncol. 1998;16:799–800
- Influence of platinum-induced renal toxicity on bleomycininduced pulmonary toxicity in patients with disseminated testicular carcinoma. Oncology. 1984;41:4–7
- Cisplatin-induced changes in bleomycin elimination. Cancer Treat Rep. 1983;67:587–589
- . Evaluation of long-term toxicity after chemotherapy for testicular cancer. J Clin Oncol. 1996;14:2923–2932
- . High-risk germ cell tumors in men. In: High response rate and severe toxicity with cisplatin, vinblastine, bleomycin, and etoposide. Cancer. 71:1993;p. 2351–2357
- . Severe nephrotoxicity: a probable complication of cis-dichlorodiammineplatinum (II) and cephalothin-gentamicin therapy. Oncology. 1982;39:31–32
- . Nephrotoxic and ototoxic agents. Clin Lab Med. 1990;10:323–354
- . Acute renal failure after cis-dichlorodiammineplatinum(II) and centamicin-cephalothin therapies. Cancer Treat Rep. 1978;62:693–698
- . Cisplatin neurotoxicity. N Engl J Med. 1990;322:126–127
- . Detection of platinum in the brain of mice treated with cisplatin and subjected to shortterm hypoxia. J Pharm Pharmacol. 1996;48:505–509
-
.
The olfactory neurotoxicity of cisplatin and effects of two drugs.
Chung Hua Erh Pi Yen Hou Ko Tsa Chih. 1995;30:233–235
- Unusual presentation of cis-platinum neuropathy. Neurology. 1988;38:488–490
- Peripheral neuropathy and ophthalmologic toxicity after treatment with cis-dichlorodiamminoplatinum II. J Cancer Res Clin Oncol. 1980;96:219–221
- Progressive paresthesias after cessation of therapy with very high-dose cisplatin. Cancer Chemother Pharmacol. 1989;25:62–64
- . Clinical and biochemical long-term toxicity after postoperative cisplatinbased chemotherapy in patients with low-stage testicular cancer. Oncology. 1995;52:300–305
- Neuropeptides and morphological changes in cisplatin-induced dorsal root ganglion neuronopathy. Exp Neurol. 1996;138:93–104
- . An ultrastructural study of neuronal changes in dorsal root ganglia (DRG) of rats after chronic cisplatin administrations. Histol Histopathol. 1995;10:837–845
- . Effect of cisplatin and ACTH4-9 on neural transport in cisplatin induced neurotoxicity. Brain Res. 1995;676:258–267
- Vibration perception and thermoperception as quantitative measurements in the monitoring of cisplatin induced neurotoxicity. J Neurol Sci. 1989;93:167–174
- . A randomized, multicenter, double-blind, placebo-controlled, dose-finding study of ORG 2766 in the prevention or delay of cisplatin-induced neuropathies in women with ovarian cancer. Gynecol Oncol. 1997;67:172–177
- . Cisplatin neuropathy: a prospective clinical and electrophysiological study in Chinese patients with ovarian carcinoma. J Clin Pharm Ther. 1995;20:167–172
- . Severe, disabling neurologic toxicity following cisplatin retreatment. Ann Pharmacother. 1995;29:134–137
-
Raynaud's phenomenon: a common toxicity after combination chemotherapy for testicular cancer.
Ann Intern Med. 1981;95:288–292
- Acute vascular ischemic events after cisplatin-based combination chemotherapy for germ-cell tumors of the testis. Ann Intern Med. 1986;105:48–51
- . cis-Platinum ototoxicity. Clin Toxicol. 1978;13:469–478
-
Ototoxicity of cis-diamminedichloroplatinum (II): influence of dose, schedule and mode of administration.
Eur J Cancer. 1983;19:53–58
- Ototoxicity from cis-platinum in patients with stages III and IV previously untreated squamous cell cancer of the head and neck. Am J Clin Oncol. 1985;8:302–306
- Hearing loss in children receiving cisplatin chemotherapy. J Pediatr. 1983;102:314–317
- . High-frequency audiometric monitoring strategies for early detection of ototoxicity. Ear Hear. 1994;15:232–239
-
.
Factors influencing ototoxicity in ovarian cancer patients treated with Cis-platinum based chemotherapy.
Eur I Gynaecol Onco1. 1992;13:35–44
- . Ototoxicity due to cis-diamminedichloroplatinum in the treatment of ovarian cancer: influence of dosage and schedule of administration. Ear Hear. 1991;12:91–102
- . Cisplatin ototoxicity in gynecologic cancer patients. Cancer. 1985;55:41–43
- . Ototoxicity of cisplatinum in children and adolescents. Br J Cancer. 1990;61:927–931
- Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration. Cancer Treat Rep. 1982;66:19–23
- cis-Platinum vestibular toxicity. Cancer. 1981;47:847–859
- . Audiometric test criteria in the detection of cisplatin ototoxicity. J Am Acad Audiol. 1992;3:176–185
- . Long-term neurotoxicity in patients treated with cisplatin, vinblastine, and bleomycin for metastatic germ cell cancer. J Clin Oncol. 1989;7:1457–1461
- . Assessment of cisplatin-induced ototoxicity using derived-band ABRs. Int J Pediatr Otorhinolaryngol. 1991;22:237–248
- . Early detection of cisplatin-induced ototoxicity using evoked otoacoustic emissions. Laryngorhinootologie. 1991;70:457–462
- . Monitoring of cisplatin ototoxicity by distortion-product otoacoustic emissions. Auris Nasus Larynx. 1996;23:147–151
-
.
Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures.
Eur I Neurosci. 1996;8:1897–1905
- . Semiquantitative analysis by scanning electron microscopy of cochlear hair cell damage by ototoxic drugs. Scanning Microsc. 1995;9:271–280
-
.
Cisplatin metabolites and their toxicity on isolated cochlear outer hair cells in vitro.
Acta Otolaryngol (Stockh). 1996;116:561–565
- . Mechanism of cisplatin ototoxicity: antioxidant system. Pharmacol Toxicol. 1995;76:386–394
- Phase I/II study of paclitaxel plus cisplatin as first-line chemotherapy for advanced non-small cell lung cancer: preliminary results. Semin Oncol. 1995;22(6 Suppl. 15):29–33
- Paclitaxel delivered as a 3-hr infusion with cisplatin in patients with gynecologic cancers: unexpected incidence of neurotoxicity. Gynecol Oncol. 1996;62:166–168
- Neurotoxicity and ototoxicity of cisplatin plus paclitaxel in comparison to cisplatin plus cyclophosphamide in patients with epithelial ovarian cancer. J Clin Oncol. 1997;15:199–206
- A phase II trial of paclitaxel and cisplatin in patients with locally advanced metastatic esophageal cancer: a preliminary report. Semin Oncol. 1997;24(6 Suppl. 19):S19–S77
- . Taxol-induced neuropathy: short-term effects of local injection. J Neurocytol. 1984;13:685–701
- . Phase I dose escalation of paclitaxel in patients with advanced ovarian cancer receiving cisplatin: rapid development of neurotoxicity is dose-limiting. J Clin Oncol. 1997;15:1965–1973
- Neurological monitoring of neurotoxicity induced by paclitaxel/cisplatin chemotherapy. Eur J Cancer. 1997;33:1393–1399
- . Peripheral neuropathy induced by combination chemotherapy of docetaxel and cisplatin. Br J Cancer. 1997;75:417–422
- Paclitaxel neurotoxicity: clinical and neurophysiological study of 23 patients. Ital J Neurol Sci. 1997;18:73–79
- Peripheral neurotoxicity of taxol in patients previously treated with cisplatin. Cancer. 1995;75:1141–1150
- Improvement of cis-dichlorodiammineplatinum (NSC 119875): therapeutic index in an animal model. Cancer. 1977;39:1357–1361
- Renal excretion kinetics of high-dose cis-dichlorodiammineplatinum (II) administered with hydration and mannitol diuresis. Cancer Treat Rep. 1979;63:13–16
- . Nephrotoxicity and hydration management for cisplatin, carboplatin, and ormaplatin. Gynecol Oncol. 1993;50:147–158
- . Allterations in the toxicity of cis-dichlorodiammineplatinum-Ii; in tissue localization of platinum as a function of Nacl concentration in the vehicle of administration. Toxicol Appl Pharmacol. 1981;61:99–108
- High-dose cisplatin in hypertonic saline. Ann Intern Med. 1984;100:19–24
- . Sequential methotrexate, 5-fluorouracil, and cisplatin in the treatment of recurrent squamous-cell carcinoma of the head and neck: failure of hypertonic saline to reduce the nephrotoxicity of cisplatin. J Clin Oncol. 1986;4:1670–1676
- . High-dose cisplatin administration without hypertonic saline: observation of disabling neurotoxicity. J Clin Oncol. 1985;3:1373–1378
- Combined systemic chemoimmunotherapy in advanced diffuse malignant mesothelioma: report of a phase I–II study of weekly cisplatin/interferon alfa-2a. J Clin Oncol. 1996;14:878–885
- . Biochemical modulation of cisplatin toxicity. Pharmacol Ther. 1989;41:371–380
- Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression. Pharmacol Ther. 1988;39:133–137
- . Biological factors affecting the radioprotective efficiency of S-2-[3-aminopropylamino] ethylphosphorothioic acid (WR-2721). LD50(30) doses. Radiat Res. 1970;44:621–628
- Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate. Biochem Pharmacol. 1992;43:1013–1019
- Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Cancer Res. 1988;48:3634–3640
- Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis. 1995;16:767–774
- . Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine. Carcinogenesis. 1997;18:2457–2459
- . WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997;30:283–294
- . Selective inhibition of the nephrotoxicity of cis-dichlorodiammineplatinum(II) by WR-2721 without altering its antitumor properties. Cancer Treat Rep. 1980;64:57–64
- Treatment of tumours with combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide. Br J Cancer. 1980;42:574–585
- . Effects of amifostine (WR-2721, ethyol) on tumor growth and pharmacology of cytotoxic drugs in human xenotransplanted neuroblastomas. Anticancer Drugs. 1997;8:174–181
- Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse. Cancer Res. 1992;52:2257–2260
-
.
Protection against cis-platin neurotoxicity in cultured dorsal root ganglion cells by WR-2721.
In: Proceedings of the 7th International Conference of Chemical Modifiers of Cancer Treatment. 1991;p. 328
-
WR-2721 protects neurons of the snail Lymnaea stagnalis from cisplatin-induced toxicity.
In:
Proc AACR. 33:1992;p. 557
WR-2721 protects neurons of the snail Lymnaea stagnalis from cisplatin-induced toxicity.
In:
Proc AACR. 33:1992;p. A3330
- WR-2721 and high-dose cisplatin: An active combination in the treatment of metastatic melanoma. J Clin Oncol. 1987;5:574–578
-
High dose cisplatin (C) and WR 2721 in metastatic melanoma.
In:
Proc ASCO. 11:1992;p. 344
High dose cisplatin (C) and WR 2721 in metastatic melanoma.
In:
Proc ASCO. 11:1992;p. A1181
- Audiological findings in a phase I protocol investigating the effect of WR 2721, highdose cisplatin and radiation therapy in patients with locally advanced cervical carcinoma. J Laryngol Otol. 1995;109:744–747
-
Amifostine protects against early cisplatin-induced renal damage and enhances CD34 cell numbers for PBSC collection.
In:
Proc ASCO. 16:1997;p. A166;
(abstract)
- Effect of amifostine on toxicities associated with sequential chemotherapy and radiation therapy for unresectable non-small-cell lung cancer: results of a phase II trial. J Clin Oncol. 1997;15:2850–2857
- . Phase II evaluation of cisplatin and WR2721 for refractory metastatic breast cancer. Am J Clin Oncol. 1997;20:368–372
-
.
Cisplatin (CDDP), radiotherapy (RT) and amifostine (WR-2721) in advanced and previously untreated cervical cancer: phase II study.
In:
]Proc ASCO. 16:1997;p. A1317;
(abstract)
-
Alternating chemotherapy (ct) + radiotherapy (rt) with amifostine (a) protection for head; neck cancer (hn).
In: Early stop of a randomized trial.
Proc Asco. 16:1997;p. A1369;
abstract
- Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatininduced toxicities: results of a randomized control trial in patients with advanced ovarian cancer. J Clin Oncol. 1996;14:2101–2112
-
Randomized phase II study of weekly cisplatin with or without amifostine in patients with advanced head and neck cancer.
Ann Oncol. 1996;7(Suppl. 5):79
Randomized phase II study of weekly cisplatin with or without amifostine in patients with advanced head and neck cancer.
Ann Oncol. 1996;7(Suppl. 5):A374P
-
.
Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model.
In:
Proc Natl Acad Sci USA. 76:1979;p. 6611–6614
-
Effect of diethlydithiocarbamate rescue on tumor response to cis-platinum in a rat model.
In:
Proc Natl Acad Sci USA. 77:1980;p. 5441–5444
- . Diethyldithiocarbamate protection against cisplatin nephrotoxicity: antioxidant system. Drug Chem Toxicol. 1995;18:151–170
- . Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: antioxidant system. Fundam Appl Toxicol. 1995;26:293–300
- . The comparative effects of sodium thiosulfate, diethyldithiocarbamate, fosfomycin and WR-2721 on ameliorating cisplatin-induced ototoxicity. Hear Res. 1995;86:195–203
- Modification of cisplatin toxicity with diethyldithiocarbamate. J Clin Oncol. 1990;8:1585–1590
- Phase I clinical and pharmacokinetic study of diethyldithiocarbamate as a chemoprotector from toxic effects of cisplatin. J Natl Cancer Inst. 1988;80:1486–1488
- . Cisplatin nephrotoxicity: diethyldithiocarbamate, WR2721, or just water?. J Clin Oncol. 1991;9:707–709
- Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721, and diethyldithiocarbamate. Crit Rev Oncol Hematol. 1990;10:353–365
- Prospective randomized trial of high-dose cisplatin; fluorouracil infusion with or without sodium diethyldithiocarbamate in recurrent and/or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 1988;6:955–962
- Randomized placebo-controlled multicenter evaluation of diethyl-dithiocarbamate for chemoprotection against cisplatin-induced toxicities. J Clin Oncol. 1995;13:490–496
- . Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines. Br J Cancer. 1998;77:556–561
- . Glutathionedependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise. Hear Res. 1997;114:75–82
- Pharmacologic modulation of reduced glutathione circadian rhythms with buthionine sulfoximine: relationship with cisplatin toxicity in mice. Toxicol Appl Pharmacol. 1997;143:281–290
- . The fate of extracellular glutathione in the rat. Biochim Biophys Acta. 1978;539:324–337
- Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve. Neurotoxicol Teratol. 1990;12:603–605
- . Protection against cisplatin toxicity by administration of glutathione ester. FASEB J. 1990;4:3251–3255
- Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester. Mol Cell Biochem. 1995;144:7–11
- Reduced glutathione protects against cisplatin-induced neurotoxicity in rats. Cancer Res. 1993;53:544–549
- Phase I trial of cisplatin in combination with glutathione. Gynecol Oncol. 1993;55:82–86
- A feasibility study of high-dose cisplatin and 5-fluorouracil with glutathione protection in the treatment of advanced colorectal cancer. Tumori. 1990;76:590–594
- Weekly 5-fluorouracil and folinic acid plus escalating doses of cisplatin with glutathione protection in patients with advanced head and neck cancer. Med Oncol Tumor Pharmacother. 1992;9:165–168
- A preoperative single course of high-dose cisplatin and bleomycin with glutathione protection in bulky stage IB/II carcinoma of the cervix. Ann Oncol. 1992;3:117–121
- High-dose cisplatin and cyclophosphamide with glutathione in the treatment of advanced ovarian cancer. Ann Oncol. 1993;4:55–61
- Evaluation by somatosensory evoked potentials of the neurotoxicity of cisplatin alone or in combination with glutathione. Ital J Neurol Sci. 1992;13:643–647
- Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebocontrolled trial. J Clin Oncol. 1995;13:26–32
- Intensive weekly chemotherapy for advanced gastric cancer using fluorouracil, cisplatin, epidoxorubicin, 6S-leucovorin, glutathione, and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer. J Clin Oncol. 1997;15:3313–3319
- . Kinetics of sodium thiosulfate, a cisplatin neutralizer. Clin Pharmacol Ther. 1984;35:419–425
- Inactivation of cisdiamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits. Cancer Chemother Pharmacol. 1985;15:228–232
- ‘Two-route chemotherapy’ using high-dose ip cisplatin and iv sodium thiosulphate, its antidote, for peritoneally disseminated cancer in mice. Cancer Treat Rep. 1984;68:1367–1373
- . Mechanism of the protective effect of sodium malate on cisplatin-induced toxicity in mice. Biol Pharm Bull. 1998;21:121–128
-
Phase I trial of escalating doses of intravenous (IV) cisplatin (C) and IV sodium thiosulfate (STS) renal protection.
In:
Proc ASCO. 7:1988;p. 55
Phase I trial of escalating doses of intravenous (IV) cisplatin (C) and IV sodium thiosulfate (STS) renal protection.
In:
Proc ASCO. 7:1988;p. A207
- High-dose cisplatin with sodium thiosulfate protection. J Clin Oncol. 1985;3:237–244
- First line immunochemotherapy with cisplatin-based protocol by intraperitoneal and intravenous routes in ovarian cancer: technique and results of 82 cases. Eur J Obstet Gynecol Reprod Biol. 1996;66:57–64
- Phase-1 trial of high-dose intravenous cisplatin with simultaneous intravenous sodium thiosulfate. J Cancer Res Clin Oncol. 1991;117:151–155
- High-dose biweekly intraperitoneal cisplatin: an effective way to increase cisplatin dose intensity. Gynecol Oncol. 1993;49:318–324
-
.
Nephrotoxicity of highdose intracavitary cisplatin with intravenous thiosulfate protection.
Eur J Cancer. 1985;21:1015–1018
- Intraperitoneal cisplatin with systemic thiosulfate protection. Ann Intern Med. 1982;97:845–851
- Phase II trial for intraperitoneal cisplatin plus intravenous sodium thiosulphate in advanced ovarian carcinoma patients with minimal residual disease after cisplatin-basedfchemotherapy: a phase II study of the EORTC Gynaecological Cancer Cooperative Group. Eur J Cancer. 1994;30A:45–49
- . Intraperitoneal high-dose cisplatin and etoposide with systemic thiosulfate protection in second-line treatment oz advanced ovarian cancer. Gynecol Oncol. 1993;49:166–171
- Phase II study of intraperitoneal cisplatin plus systemic etoposide as secondline treatment in patients with small volume residual ovarian cancer. Eur J Cancer. 1995;31A:709–713
- . Experience with intraperitoneal cisplatin and etoposide and i.v. sodium thiosulphate protection in ovarian cancer patients with either pathologically complete response or minimal residual disease. Ann Oncol. 1997;8:1235–1241
- . Acute renal failure associated with intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection in ovarian cancer patients. Eur J Gynaecol Oncol. 1991;12:403–406
- Prevention of cisplatin neurotoxicity with an ACTH(4-9) analogue in patients with ovarian cancer. N Engl J Med. 1990;322:89–94
- Enhancement of regeneration by ORG 2766 after nerve crush depends on the type of neural injury. Eur J Pharmacol. 1992;214:33–37
- Co-administration of the neurotrophic ACTH(4-9) analogue, ORG 2766, may reduce the cochleotoxic effects of cisplatin. Hear Res. 1997;106:9–19
-
A double-blind randomised study with ORG-2766 an ACTH(4-9) analog, to prevent cisplatin neuropathy.
In:
Proc ASCO. 13:1994;p. 261
A double-blind randomised study with ORG-2766 an ACTH(4-9) analog, to prevent cisplatin neuropathy.
In:
Proc ASCO. 13:1994;p. A837
- Protective effect of fosfomycin against aminoglycoside ototoxicity. ORL J Otorhinolaryngol Relat Spec. 1985;47:42–48
- Amelioration of cisplatin-induced ototoxicity by fosfomycin. Laryngoscope. 1986;96:948–958
-
.
Reduction of cisplatin toxicity by fosfomycin in animal models.
Jpn I Cancer Chemother. 1984;11:2400–2407
- Preventive effect of fosfomycin on the renal toxicity of cisplatin. Jpn J Antibiot. 1985;38:62–68
- Supplemental fosfomycin and/or steroids that reduce cisplatin-induced nephrotoxicity. Am J Med Sci. 1988;295:6–10
-
.
Pantothenic acid and coenzyme A in experimental cisplatin-induced ototoxia.
Acta Otolaryngol (Stockh). 1996;116:263–268
- . 4-Methylthiobenzoic acid reduces cisplatin nephrotoxicity in rats without compromising anti-tumour activity. Biochem Pharmacol. 1991;41:1997–2003
- . Protection by 4-methylthiobenzoic acid against cisplatin-induced ototoxicity: antioxidant system. Pharmacol Toxicol. 1997;81:173–179
- . Image analysis of neuritic regeneration by adult rat dorsal root ganglion neurons in culture: quantification of the neurotoxicity of anticancer agents and of its prevention by nerve growth factor or basic fibroblast growth factor but not brainderived neurotrophic factor or neurotrophin-3. J Neurosci Methods. 1994;53:111–122
- . Neurotrophin-4/5, brainderived neurotrophic factor, and neurotrophin-3 promote survival of cultured vestibular ganglion neurons and protect them against neurotoxicity of ototoxins. J Neurobiol. 1995;28:330–340
- . Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity. J Neurosci. 1995;15:5079–5087
- Protection of both auditory hair cells and auditory neurons from cisplatin induced damage. Acta Otolaryngol. 1997;117:232–238
- . D-methionine provides excellent protection from cisplatin ototoxicity in the rat. Hear Res. 1996;102:90–98
- Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Ann Neurol. 1995;38:30–37
- . Cisplatin-induced ototoxicity: the effect of pigmentation and inhibitory agents. Laryngoscope. 1993;103:1–52
- . Failure of a 21-aminosteroid antioxidant to ameliorate cisplatin-induced nephrotoxicity. Hum Exp Toxicol. 1991;10:323–326
- . Protective effects of betamipron on renal toxicity during repeated cisplatin administration in rats and protective mechanism. Ren Fail. 1998;20:27–38
- The use of probenecid as a chemoprotector against cisplatin nephrotoxicity. Cancer. 1991;67:1518–1524
- Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity. Br J Cancer. 1996;74:2036–2041
- . Protective role of metallothionein in renal toxicity of cisplatinum. Cancer Chemother Pharmacol. 1997;40:358–362
PII: S0305-7372(98)90061-5
« Previous
Next »
Cancer Treatment Reviews
Volume 24, Issue 4
, Pages 265-281
, August 1998
