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Cancer Treatment Reviews
Volume 37, Issue 3
, Pages 169-177
, May 2011
Evolving strategies for the treatment of hepatocellular carcinoma: From clinical-guided to molecularly-taylored therapeutic options
References
- Global cancer statistics, 2002. Ca Cancer J Clin. 2005;55:74–108
- Epidemiology, risk factors and natural history of hepatocellular carcinoma. Ann NY Acad Sci. 2002;963:13–20
- Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol. 2008;14(27):4300–4308
- . The rise and fall in primary liver cancer mortality in Italy. Digestive Liver Dis. 2002;34:169–171
- Primary liver cancer: worldwide incidence and trends. Gastroenterology. 2004;127:S5–S16
- . Epidemiology of hepatocellular carcinoma in USA. Hepatol Res. 2007;37(Suppl. 2):S88–S94
- . Hepatocellular cancer: a guide for the internist. Am J Med. 2007;120:194–202
- Host immune status and incidence of hepatocellular carcinoma among subject infected with hepatitis C virus: a nested case-control study in Japan. Cancer Epidemiol Biomarkers Prev. 2006;15:2521–2525
- . Hepatitis B virus related hepatocellular carcinoma: epidemiology and pathogenic role of viral factors. J Chin Med Assoc. 2007;70:141–145
- . Alcohol and liver cancer. Alcohol. 2005;35:195–203
- . Alcohol in hepatocellular cancer. Clin Liver Dis. 2005;9:151–169
- Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenetic cirrhosis to hepatocellular carcinoma. Gastroenterology. 2002;123:134–140
- . Diabetes mellitus: a “true” independent risk factor for hepatocellular carcinoma?. Hepatobiliary Pancreat Dis Int. 2009;8:465–473
- Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection. Ann Oncol. 2009;20(10):1736–1740
- . Dysplastic nodules and hepatocarcinogenesis. Clin Liver Dis. 2002;6:497–512
- Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol. 2003;39:208–214
- . Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis. Cancer. 2001;92:2733–2738
- Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type. Hepatol Res. 2003;26:142–147
- . Progenitor cells in diseased human liver. Semin Liver Dis. 2003;23:385–396
- . Cellular origin of hepatocellular carcinomas. Semin Cell Dev Biol. 2002;13:419–424
- . Regulatory mechanisms of viral hepatitis B and C. J Biosci. 2003;28:311–321
- . Interaction between hepatitis C virus protein and host cell factors. Curr Opin Microbiol. 2002;5:419–427
- Molecular viral oncology of hepatocellular carcinoma. Oncogene. 2003;22:5093–5107
- Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene. 2001;20:2606–2610
- Ethanol and oxidative stress. Alcohol Clin Exp Res. 2001;25(5 Suppl. ISBRA):237S–243S
- . Regulation of glutathione synthesis. Cur Top Cell Regul. 2000;36:95–116
- . Recent events in alcoholic liver disease. V. Effects of ethanol on liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2005;288:G1–G6
- . Update treatment approach to hepatocellular carcinoma. J Gastroenterol. 2005;40:225–235
- A model to predict survival in patients with and-stage liver disease. Hepatology. 2001;33:464–470
- . Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology. 2003;37:429–442
- Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology. 1999;29:62–67
- Simplified staging for hepatocellular carcinoma. J Clin Oncol. 2002;20:1527–1536
- . AJCC cancer staging manual. 6th ed.. New York: Springer; 2002;
- Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer. 1985;56:918–928
- Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients. Cancer. 2002;94:1760–1769
- . Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology. 2000;31:840–845
- A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. J Hepatol. 1999;31:133–141
- Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score. Hepatology. 2004;40:1396–1405
- Modified Japan integrated staging is currently the best available staging system for hepatocellular carcinoma patients who have undergone hepatectomy. J Gastroenterol. 2006;41:250–256
- . Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19:329–338
- . The model for end-stage liver disease (MELD). Hepatology. 2007;45:797–805
- . Management of hepatocellular carcinoma. AASLD practice guideline. Hepatology. 2005;42:1208–1236
- . Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: review of the randomized clinical trials. Lancet Oncol. 2002;3:593–603
- Small hepatocellular carcinoma in cirrhosis: randomized controlled trial of radiofrequency thermal ablation versus percutaneous ethanol injection. Radiology. 2003;228:235–240
- Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma of 4
cm or less. Gastroenterology. 2004;127:1714–1723 - . Chemotherapy in hepatocellular carcinoma. Hepatogastroenterology. 1998;45(Suppl. 3):1259–1263
- Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24:4293–4300
- SHARP investigators. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a phase III randomized placebo-controlled trial. J Clin Oncol. 2007;LBA1
- Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst. 2008;100:698–711
- BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099–7109
- Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol. 2007;59:561–574
- Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis. 2007;27:55–76
- Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology. 2006;130:1117–1128
- . Angiogenesis and hepatocellular carcinoma. J Hepatol. 2004;41:864–880
- BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099–7109
- Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006;66:11851–11858
- Randomized phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma. J Clin Oncol. 2008;ù 26:4509
- SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003;101:3597–3605
- A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2007;25:4637
- Assessment of safety and drug induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). J Clin Oncol. 2007;25:3546
- Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer. 2007;110:581–589
- . A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results. J Clin Oncol. 2007;25:A4594
- Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol. 2005;23:6657–6663
- Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer. 2007;110:1059–1067
- Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group’s Study E1203. J Clin Oncol. 2006;24:4143
- Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. J Clin Oncol (Meeting Abstracts). 2006;24(18S):[Abstract 4010]
- Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann Surg Oncol. 2003;55–62
- Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br J Surg. 2004;91:1354–1360
- Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol. 2008;26:2992–2998
- The combination of bevacizumab and erlotinib shows significant biological activity in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2007;25:4567
- . Bevacizumab in unresectable hepatocellular carcinoma for patients without metastasis and without invasion of the portal vein. J Clin Oncol. 2006;24:A4144
- Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24:1898–1903
- . Influence of hepatic dysfunction on safety, tolerability and pharmacokinetics of PTK787/ZK222584 in patients with unresectable HCC. J Clin Oncol. 2005;23:A4134
- Alberts SR, Morlan BW, Kim GP, et al. NCCTG phase II trial (N044J) of AZD2171 for patients with hepatocellular carcinoma (HCC)–interim review of toxicity. In: 2007 Gastrointestinal cancer symposium, Orlando, FL, January 19–21, 2007 [Abstract 186].
- MTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res. 2004;10:8421–8425
- In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin. Histol Histopathol. 2007;22:285–289
- Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation. 2007;83:425–432
- Available at: <http://www.cancer.gov/clinicaltrials/search>.
- Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: relationship to clinicopathological factors and prognosis after hepatic resection. J Gastroenterol. 2004;39(2):148–154
- Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma. Dig Surg. 2000;17:42–48
- Prognostic significance of Bcl-xLIto in human hepatocellular carcinoma. Surgery. 2004;135(6):604–612
- Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome. Mod Pathol. 2004;17:1378–1385
- Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. Clin Cancer Res. 2002;8(10):3131–3136
- Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol. 2000;156:393–398
- Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy. Am J Surg. 2001;181:284–288
- Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas. Anticancer Res. 2001;21:657–662
- Acquired expression of p27 is a favorable prognostic indicator in patients with hepatocellular carcinoma. Clin Cancer Res. 2000;6:3966–3972
- Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas. Clin Cancer Res. 2003;9(5):1764–1772
- P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection. World J Gastroenterol. 2002;8(3):459–463
- . Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res. 2001;7:594–599
- Expression and prognostic roles of β-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival. Clin Cancer Res. 2002;8:450–456
- . Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol. 2000;32:78–84
- Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Br J Cancer. 2001;84:1377–1383
- Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours. Dig Liver Dis. 2003;35:332–338
- Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma. Int J Cancer. 2002;97:425–431
- Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor. J Cancer Res Clin Oncol. 2000;126:641–646
PII: S0305-7372(10)00136-2
doi: 10.1016/j.ctrv.2010.08.001
© 2010 Elsevier Ltd. All rights reserved.
« Previous
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Cancer Treatment Reviews
Volume 37, Issue 3
, Pages 169-177
, May 2011
