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Cancer Treatment Reviews
Volume 36, Issue 1
, Pages 83-90
, February 2010
EORTC Elderly Task Force experts’ opinion for the treatment of colon cancer in older patients
References
- . Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108
- . Chemotherapy in elderly patients with colorectal cancer. Oncologist. 2008;13(4):390–402
- . Geriatric oncology: challenges for the new century. Eur J Cancer. 2000;36(14):1741–1754
- . The challenges and achievements involved in implementing quality of life research in cancer clinical trials. Eur J Cancer. 2003;39(3):275–285
- . Age and clinical decision making in oncology patients. J Natl Cancer Inst. 1994;86(23):1766–1770
- . Management of cancer in the older person: a practical approach. Oncologist. 2000;5(3):224–237
- . Underrepresentation of patients 65 years of age or older in cancer-treatment trials. New Engl J Med. 1999;341(27):2061–2067
- Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol. 2003;21(7):1383–1389
- . Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer. J Clin Oncol. 2002;20(5):1192–1202
- . The geriatric cancer patient: equal benefit from equal treatment. Cancer Control. 2001;8(2 Suppl.):1–25
- . Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. J Clin Oncol. 2005;23(13):3112–3124
- . Understanding the attitudes of the elderly towards enrolment into cancer clinical trials. BMC Cancer. 2006;6:34
- Barriers to enrollment of elderly adults in early-phase cancer clinical trials. J Oncol Pract. 2008;4(4):162–168
- Surgery for colorectal cancer in elderly patients: a systematic review. Colorectal Cancer Collaborative Group. Lancet 2000;356(9234):968–74.
- . The United Kingdom National Bowel Cancer Project – epidemiology and surgical risk in the elderly. Eur J Cancer. 2007;43(15):2285–2294
- . The effect of age and gender on outcome after treatment for colon carcinoma. A population-based study in the Uppsala and Stockholm region. Crit Rev Oncol Hematol. 2008;67(3):229–236
- . Colorectal cancer surgery in the elderly: acceptable morbidity?. Am J Surg. 2008;195(3):344–348
- . Colorectal cancer in the elderly: surgical treatment and long-term survival. Int J Colorectal Dis. 2008;23(6):601–610
- . Colon resection in elderly patients: comparison of data of a single surgical department with collective data from the Czech Republic. Arch Gerontol Geriatr. 2005;41(2):183–190
- Surgical treatment of advanced colorectal cancer in the elderly. Chir Ital. 2005;57(5):589–596
- . Survival after operations for colorectal cancer in patients aged 75 years or over. Eur J Surg. 2000;166(6):473–479
- Colorectal cancer in the elderly. Is there a role for safe and curative surgery?. ANZ J Surg. 2008;78(6):466–470
- Should patients over 85 years old be operated on for colorectal cancer?. J Clin Gastroenterol. 2004;38(5):408–413
- . Morbidity and mortality in octogenarians and older undergoing major intestinal surgery. Dis Colon Rectum. 2009;52(1):59–63
- . Outcome of right colectomy for cancer in octogenarians. J Gastrointest Surg. 2009;13(1):100–104
- Outcomes of Veterans affairs patients older than age 80 after surgical procedures for colon malignancies. Am J Surg. 2007;194(5):646–651
- . Surgical management of oncogeriatric patients. J Clin Oncol. 2007;25(14):1924–1929
- . A wide difference in cancer survival between middle aged and elderly patients in Europe. Int J Cancer. 2007;120(10):2196–2201
- Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study. Crit Rev Oncol Hematol. 2008;65(2):156–163
- . Vulnerability in the elderly: frailty. Med Clin North Am. 2006;90(4):593–601
- . Postoperative mortality and morbidity in French patients undergoing colorectal surgery: results of a prospective multicenter study. Arch Surg. 2005;140(3):278–283[discussion]
- . Comorbidity in older surgical cancer patients: influence on patient care and outcome. Eur J Cancer. 2007;43(15):2179–2193
- Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery. Surg Oncol. 2006;15(4):189–197
- . Safety and advantages of laparoscopic vs. open colectomy in the elderly: matched-control study. Dis Colon Rectum. 2000;43(3):326–332
- . Laparoscopic colorectal resection: a safe option for elderly patients. J Am Coll Surg. 2002;195(6):768–773
- . Advantages of laparoscopic colectomy in older patients. Arch Surg. 2003;138(3):252–256
- Clinical advantages of laparoscopic colorectal cancer surgery in the elderly. Aging Clin Exp Res. 2006;18(3):191–195
- . Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999;230(3):309–318
- . First and repeat resection of colorectal liver metastases in elderly patients. Ann Surg. 2004;240(5):858–865
- Surgical treatment of liver metastases from colorectal cancer in elderly patients. Int J Colorectal Dis. 2007;22(1):77–83
- Validity of hepatic resection of colorectal liver metastases in the elderly (75 years and older). Anticancer Res. 2009;29(2):583–588
- Major resection of hepatic colorectal liver metastases in elderly patients – an aggressive approach is justified. Eur J Surg Oncol. 2008;34(4):428–432
- Major liver resections in the elderly – is an aggressive approach justified?. Int J Colorectal Dis. 2009;24(1):83–86
- . Liver resection for colorectal liver metastases in older patients. Crit Rev Oncol Hematol. 2008;67(3):273–278
- Surgical treatment of liver metastases from colorectal carcinoma in elderly patients. When is it worthwhile?. Clin Transl Oncol. 2007;9(6):392–400
- . Adjuvant chemotherapy for colon cancer. Anticancer Res. 2006;26(6C):4809–4815
- . Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med. 2002;136(5):349–357
- . Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. JAMA. 2005;294(21):2703–2711
- Duration of adjuvant chemotherapy for colon cancer and survival among the elderly. J Clin Oncol. 2006;24(15):2368–2375
- Adjuvant treatments do not alter the quality of life in elderly patients with colorectal cancer: a population-based study. Cancer. 2008;113(4):879–886
- Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colon carcinoma: a 10-year experience of the Geisinger Medical Center. Cancer. 2002;94(7):1931–1938
- . Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol. 1999;17(8):2412–2418
- A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. New Engl J Med. 2001;345(15):1091–1097
- Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet. 2007;370(9604):2020–2029
- Capecitabine as adjuvant treatment for stage III colon cancer. New Engl J Med. 2005;352(26):2696–2704
- Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. Ann Oncol. 2003;14(12):1735–1743
- International society of geriatric oncology chemotherapy taskforce: evaluation of chemotherapy in older patients – an analysis of the medical literature. J Clin Oncol. 2007;25(14):1832–1843
- Twelves C, Scheithauer W, McKendrick J, et al. Capecitabine versus 5-FU/LV in stage III colon cancer: updated 5-year efficacy data from X-ACT trial and preliminary analysis of relationship between hand-foot syndrome (HFS) and efficacy. In: ASCO gastrointestinal cancers symposium; 2008 [abstr 274].
- Field KM, Kosmider S, Desai J, Lim L, Barnett F, Gibbs P. Capecitabine in colorectal cancer: a five-year review of use in routine clinical care. In: ASCO gastrointestinal cancers symposium; 2009.
- Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol. 2006;24(25):4085–4091
- Impact of older age on the efficacy of newer adjuvant therapies in >12,500 patients (pts) with stage II/III colon cancer: findings from the ACCENT database. J Clin Oncol. 2009;27(15s):[abstr 4010]
- Initial safety report of NSABP C-08: a randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J Clin Oncol. 2009;27(20):3385–3390
- Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol. 2004;15(9):1330–1338
- Advanced colorectal cancer in the elderly: results of consecutive trials with 5-fluorouracil-based chemotherapy. Cancer Chemother Pharmacol. 1998;42(4):336–340
- First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol. 2002;13(4):566–575
- Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet. 2000;355(9209):1041–1047
- Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J Clin Oncol. 2005;23(22):4856–4865
- Predictive factors of survival in patients with advanced colorectal cancer: an individual data analysis of 602 patients included in irinotecan phase III trials. Ann Oncol. 2004;15(7):1013–1017
- Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Brit J Cancer. 2004;91(8):1453–1458
- Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2691 patients in randomized controlled trials. J Clin Oncol. 2008;26(9):1443–1451
- FOLFOX in patients aged between 76 and 80 years with metastatic colorectal cancer: an exploratory cohort of the OPTIMOX1 study. Cancer. 2007;110(12):2666–2671
- Capecitabine (Cap) and oxaliplatin (Ox) in elderly and/or frail patients with metastatic colorectal cancer: the FOCUS2 trial. J Clin Oncol. 2007;25;[abstr 9030]
- Mitry E, Phelip JM, Bonnetain F, et al. Phase III trial of chemotherapy with or without irinotecan in the front-line treatment of metastatic colorectal cancer in elderly patients (FFCD 2001-02 trial): results of a planned interim analysis. In; ASCO gastrointestinal cancers symposium; 2008 [abstr 281].
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. New Engl J Med. 2004;350(23):2335–2342
- Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst. 2007;99(16):1232–1239
- . Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials. J Clin Oncol. 2009;27(2):199–205
- Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol. 2008;26(33):5326–5334
- Safety and effectiveness of bevacizumab (BV) and chemotherapy (CT) in elderly patients (pts) with metastatic colorectal cancer (mCRC): Results from the BRiTE observational cohort study. J Clin Oncol. 2008;[abstr 4026]
- Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol. 2009;[April 30]
- Safety and efficacy of bevacizumab and chemotherapy in elderly patients with metastatic colorectal cancer: results from the BEAT observational cohort study. Ann Oncol. 2009;20(Suppl. 7):PD-0005
- Cetuximab efficacy and safety in a retrospective cohort of elderly patients with heavily pretreated metastatic colorectal cancer. Crit Rev Oncol Hematol. 2008;67(3):255–262
PII: S0305-7372(09)00161-3
doi: 10.1016/j.ctrv.2009.10.008
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Cancer Treatment Reviews
Volume 36, Issue 1
, Pages 83-90
, February 2010
