Cancer Treatment Reviews
Volume 36, Issue 1 , Pages 8-15, February 2010

Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer

  • Anastasia Malek

      Affiliations

    • Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charité Universitätsmedizin Berlin, Germany
    • Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    • ,
  • Reinhold Schäfer

      Affiliations

    • Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charité Universitätsmedizin Berlin, Germany
    • Corresponding Author InformationCorresponding author. Address: Institute of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Tel.: +49 30 450 536 072; fax: +49 30 450 536 909.
    • ,
  • Oleg Tchernitsa

      Affiliations

    • Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charité Universitätsmedizin Berlin, Germany

Received 21 July 2009; accepted 27 October 2009. published online 30 November 2009.

Summary 

Gene expression profiling studies and conventional approaches for the identification of genes involved in the initiation and progression of ovarian cancer have identified a plethora of potential therapeutic targets. This review summarizes the targets that show promise for specific interference in cancer cells, groups them according to their subcellular localization and involved biological processes and discusses their impact on experimental, pre-clinical and clinical therapy.

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PII: S0305-7372(09)00158-3

doi:10.1016/j.ctrv.2009.10.005

Cancer Treatment Reviews
Volume 36, Issue 1 , Pages 8-15, February 2010

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