Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer

Received 21 July 2009; accepted 27 October 2009. published online 30 November 2009.

Summary

Gene expression profiling studies and conventional approaches for the identification of genes involved in the initiation and progression of ovarian cancer have identified a plethora of potential therapeutic targets. This review summarizes the targets that show promise for specific interference in cancer cells, groups them according to their subcellular localization and involved biological processes and discusses their impact on experimental, pre-clinical and clinical therapy.

a Laboratory of Molecular Tumor Pathology, Institute of Pathology, Charité Universitätsmedizin Berlin, Germany

b Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

Corresponding author. Address: Institute of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Tel.: +49 30 450 536 072; fax: +49 30 450 536 909.

PII: S0305-7372(09)00158-3

doi:10.1016/j.ctrv.2009.10.005

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