Cancer Treatment Reviews
Volume 36, Issue 1 , Pages 1-7 , February 2010

Giant cell tumor of the extremity: A review of 349 cases from a single institution

  • Costantino Errani

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 051 6366222; fax: +39 051 331710.
  • ,
  • Pietro Ruggieri

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Tel.: +39 051 6366460; fax: +39 051 331710.
  • ,
  • Marco Antonio Nogales Asenzio

      Affiliations

    • Servicio de Cirugia Ortopedica y Traumatología, Hospital Universitario Infanta Cristina, Badajoz, Spain
    • Tel.: +39 051 6366222; fax: +39 051 331710.
  • ,
  • Angelo Toscano

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Tel.: +39 051 6366222; fax: +39 051 331710.
  • ,
  • Simone Colangeli

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Tel.: +39 051 6366222; fax: +39 051 331710.
  • ,
  • Eugenio Rimondi

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Tel.: +39 051 6366376; fax: +39 051 6366280.
  • ,
  • Giuseppe Rossi

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Tel.: +39 051 6366028; fax: +39 051 6366280.
  • ,
  • Alessandra Longhi

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Tel.: +39 051 6366374; fax: +39 051 6366277.
  • ,
  • Mario Mercuri

      Affiliations

    • Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, 40136 Bologna, Italy
    • Tel.: +39 051 6366222; fax: +39 051 331710.

Received 22 May 2009 ,Revised 18 September 2009 ,Accepted 25 September 2009.

References 

  1. Campanacci M. Bone and soft tissue tumors. 2nd ed.. New York, NY: Springer; 1999;
  2. Enneking WF. Musculoskeletal tumor surgery. New York (NY): Churchil Livingstone, Inc.; 1983.
  3. Lackman RD, Crawford EA, King JJ, Ogilvie CM. Conservative treatment of Campanacci Grade III proximal humerus giant cell tumors. Clin Orthop Relat Res. 2008.
  4. Prosser GH, Baloch KG, Tillman RM, Carter SR, Grimer RJ. Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone?. Clin Orthop Relat Res. 2005;435:211–218
  5. Enneking WF, Dunham W, Gebhardt MC, Malawar M, Pritchard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993;286:241–246
  6. Kivioja AH, Blomqvist C, Hietaniemi K, Trovik C, et al. Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years. Acta Orthop. 2008;79(1):86–93
  7. Sakayama K, Yamamoto H, Sugawara Y, et al. Diagnostic and therapeutic problems of giant cell tumor in the proximal femur. Arch Orthop Trauma Surg. 2007;127(10):867–872
  8. Turcotte RE, Wunder JS, Isler MH, et al. Giant cell tumor of long bone: a Canadian Sarcoma Group study. Clin Orthop Relat Res. 2002;397:248–258
  9. Lausten GS, Jensen PK, Schiodt T, Lund B. Local recurrences in giant cell tumour of bone. Long-term follow-up of 31 cases. Int Orthop. 1996;20(3):172–176
  10. Szendroi M, Kiss J, Antal I. Surgical treatment and prognostic factors in giant-cell tumor of bone. Acta Chir Orthop Traumatol Cech. 2003;70(3):142–150
  11. Wang HC, Chien SH, Lin GT. Management of grade III giant cell tumors of bones. J Surg Oncol. 2005;92(1):46–51
  12. Lackman RD, Hosalkar HS, Ogilvie CM, Torbert JT, Fox EJ. Intralesional curettage for grades II and III giant cell tumors of bone. Clin Orthop Relat Res. 2005;438:123–127
  13. Mendenhall WM, Zlotecki RA, Scarborough MT, Gibbs CP, Mendenhall NP. Giant cell tumor of bone. Am J Clin Oncol. 2006;29(1):96–99
  14. Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am. 2006;37(1):35–51
  15. Capanna R, Fabbri N, Bettelli G. Curettage of giant cell tumor of bone. The effect of surgical technique and adjuvants on local recurrence rate. Chir Organi Mov, 1990;LXXV(Suppl. 1).
  16. Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, et al. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008;134(9):969–978
  17. Szendroi M. Giant cell tumor of bone. Review article. J Bone Joint Surg (Br). 2004;86(1):5–12
  18. Gitelis S, Mallin BA, Piasecki P, Turner F. Intralesional excision compared with en bloc resection for giant-cell tumors of bone. J Bone Joint Surg Am. 1993;75(11):1648–1655
  19. Pals SD, Wilkins RM. Giant cell tumor of bone treated by curettage, cementation, and bone-grafting. Orthopedics. 1992;15(6):703–708
  20. Richardson MJ, Dickinson IC. Giant cell tumor of bone. Bull Hosp Jt Dis. 1998;57(1):6–10
  21. Labs K, Perka C, Schmidt RG. Treatment of stages 2 and 3 giant-cell tumor. Arch Orthop Trauma Surg. 2001;121(1–2):83–86
  22. Rooney RJ, Asirvatham R, Lifeso RM, Ali MA, Parikh S. Giant cell tumour of bone. A surgical approach to grade III tumours. Int Orthop. 1993;17(2):87–92
  23. Waldram MA, Sneath RS. Is bone graft necessary? Analysis of twenty cases of giant cell tumour of bone treated by curettage without graft. Int Orthop. 1990;14(2):129–133
  24. Blackley HR, Wunder JS, Davis AM, White LM, Kandel R, Bell RS. Treatment of giant-cell tumors of long bones with curettage and bone-grafting. J Bone Joint Surg Am. 1999;81(6):811–820
  25. Oh JH, Yoon PW, Lee SH, Cho HS, Kim WS, Kim HS. Surgical treatment of giant cell tumour of long bone with anhydrous alcohol adjuvant. Int Orthop. 2006;30(6):490–494
  26. Balke M, Ahrens H, Streitbuerger A, Koehler G, Winkelmann W, Gosheger G, et al. Treatment options for recurrent giant cell tumors of bone. J Cancer Res Clin Oncol. 2009;135:149–158
  27. von Steyern FV, Kristiansson I, Jonsson K, Mannfolk P, Heinegård D, Rydholm A. Giant-cell tumour of the knee: the condition of the cartilage after treatment by curettage and cementing. J Bone Joint Surg Br. 2007;89(3):361–365
  28. McGough RL, Rutledge J, Lewis VO, Lin PP, Yasko AW. Impact severity of local recurrence in giant cell tumor of bone. Clin Orthop Relat Res. 2005;438:116–122
  29. O’Donnell RJ, Springfield DS, Motwani HK, Ready JE, Gebhardt MC, Mankin HJ. Recurrence of giant-cell tumors of the long bones after curettage and packing with cement. J Bone Joint Surg Am. 1994;76(12):1827–1833
  30. Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69(1):106–114
  31. Sanerkin NG. Malignancy, aggressiveness, and recurrence in giant cell tumor of bone. Cancer. 1980;46(7):1641–1649
  32. Trieb K, Bitzan P, Lang S, Dominkus M, Kotz R. Recurrence of curetted and bone-grafted giant-cell tumours with and without adjuvant phenol therapy. Eur J Surg Oncol. 2001;27(2):200–202
  33. Dreinhofer KE, Rydholm A, Bauer HC, Kreicbergs A. Giant-cell tumours with fracture at diagnosis. Curettage and acrylic cementing in ten cases. J Bone Joint Surg Br. 1995;77(2):189–193
  34. Deheshi BM, Jaffer SN, Griffin AM, Ferguson PC, Bell RS, Wunder JS. Joint salvage for pathologic fracture of giant cell tumor of the lower extremity. Clin Orthop Relat Res. 2007;459:96–104
  35. Cheng CY, Shih HN, Hsu KY, Hsu RW. Treatment of giant cell tumor of the distal radius. Clin Orthop Relat Res. 2001;383:221–228
  36. Sheth DS, Healey JH, Sobel M, Lane JM, Marcove RC. Giant cell tumor of the distal radius. J Hand Surg Am. 1995;20(3):432–440
  37. Harness GN, Henry JM. Giant-cell tumor of the distal forearm. J Hand Surg Am. 2004;29(2):188–193
  38. Masui F, Ushigome S, Fujii K. Giant cell tumor of bone: a clinicopathologic study of prognostic factors. Pathol Int. 1998;48(9):723–729
  39. Siebenrock KA, Unni KK, Rock MG. Giant-cell tumour of bone metastasising to the lungs. A long-term follow-up. J Bone Joint Surg Br. 1998;80(1):43–47
  40. Sanjay BK, Kadhi SM. Giant cell tumour of bone with pulmonary metastases: a report of three cases. Int Orthop. 1998;22(3):200–204
  41. Dominkus M, Ruggieri P, Bertoni F, Briccoli A, Picci P, Rocca M, et al. Histologically verified lung metastases in benign giant cell tumours – 1 cases from a single institution. Int Orthop. 2006;30(6):499–504
  42. Eckardt JJ, Grogan TJ. Giant cell tumor of bone. Clin Orthop Relat Res. 1986;204:45–58
  43. Lim YW, Tan MH. Treatment of benign giant cell tumours of bone in Singapore. Ann Acad Med Singapore. 2005;34(3):235–237
  44. Moore AT, Bohlman HR. Metal hip joint. A case report. J Bone Joint Surg. 1943;25:688
  45. Irwin RB, Sauchak JA, O’Brien MP. Tumors of the proximal femur: case examples and literature review. Orthopedics. 1998;21(2):182–189[quiz 190-1]
  46. Wai EK, Davis AM, Griffin A, Bell RS, Wunder JS. Pathologic fractures of the proximal femur secondary to benign bone tumors. Clin Orthop Relat Res. 2001;393:279–286

PII: S0305-7372(09)00140-6

doi: 10.1016/j.ctrv.2009.09.002

Cancer Treatment Reviews
Volume 36, Issue 1 , Pages 1-7 , February 2010