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Cancer Treatment Reviews
Volume 35, Issue 8
, Pages 662-667
, December 2009
The role of topoisomerase IIα and HER-2 in predicting sensitivity to anthracyclines in breast cancer patients
References
- Early Breast Cancer Trialists’ Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365:1687–717.
- BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. Cancer Res. 2007;67:7078–7081
- . Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations. J Clin Oncol. 2009;8:1323–1333
- HER-2/neu in systemic therapy for women with breast cancer: a systemic review. Breast Cancer Res Treat. 2008;109:209–229
- HER-2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials. J Natl Cancer Inst. 2008;100:14–20
- . DeVita, Hellman, and Rosenberg’s cancer: principles & practice of oncology. 8th ed.. Philadelphia, PA: Lippincott Williams and Wilkins; 2008;
- Physiological regulation of eukaryotic topoisomerase II. Biochim Biophys Acta. 1998;1400:121–137
- Cell cycle-coupled variation in topoisomerase II alpha mRNA is regulated by the 3′-untranslated region. Possible role of redox sensitive protein binding in mRNA accumulation. J Biol Chem. 2000;275:383384–383392
- Correlation between topoisomerase-II alpha gene amplification and protein expression in HER-2 amplified breast cancer. Int J Oncol. 2004;25:1473–1479
- Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples. Genes Chromosomes Cancer. 2004;39:288–297
- Identification and validation of prognostic markers in breast cancer with complementary use of array-CGH and tissue microarrays. J Pathol. 2005;205:388–396
- Predictive value of topoisomerase II alpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer. Br J Cancer. 1998;77:2267–2273
- Expression of topoisomerase II alpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 over expression in breast cancer. Am J Pathol. 1996;148:2073–2082
- DNA topoisomerase II-alpha immunoreactivity as a marker of tumor aggressiveness in invasive breast cancer. Pathobiology. 2000;68:137–143
- . Anthracyclines: the first generation of cytotoxic targeted agents? A possible dream. J Clin Oncol. 2008;31:5027–5035
- . Heterogeneous expression of DNA topoisomerase II alpha isoforms in tumor cell lines. Oncol Res. 1997;9:193–204
- . Identification of functional nuclear export sequences in human topoisomerase II alpha and beta. Biochem Biophys Res Commun. 2003;306:905–911
- Human topoisomerase II alpha nuclear export is mediated by two CRM-1-dependent nuclear export signals. J Cell Sci. 2004;117:3061–3071
- Changes in subcellular distribution of topoisomerase II alpha correlate with etoposide resistance in multicell spheroid and xenograft tumours. Cancer Res. 2000;60:5747–5753
- Ectopic expression of human topoisomerase II alpha fragments and etoposide resistance in mammalian cells. Int J Cancer. 2000;88:99–107
- . HER-2/neu and topoisomerase II alpha in breast cancer. Breast Cancer Res Treat. 2003;78:299–311
- HER-2, TOP2A and chromosome 17 alterations in breast cancer. Pathol Oncol Res. 2007;13:180–185
- . TOP2A and HER-2 gene amplification in fine needle aspirates from breast carcinomas. Cytopathology. 2003;14:314–319
- Slamon DJ, Mackey J, Robert N, et al. Role of anthracycline-based therapy in the adjuvant treatment of breast cancer: efficacy analyses determined by molecular subtypes of the disease. San Antonio Breast Cancer Sympos 2007:13 [abstract].
- Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. J Natl Cancer Inst. 2009;101:644–650
- Gennari A, Sormani M, Pfeffer U, et al. TOP mRNA expression in HER2 negative breast cancer. San Antonio Breast Cancer Sympos 2008:6036 [abstract].
- McArthur HL, Tan LK, Patil S, et al. High resolution representational oligonucleotide microarray analysis (ROMA) suggests that TOPO2 and HER2 coamplification is uncommon in human breast cancer. San Antonio Breast Cancer Sympos 2009:69 [abstract].
- ErbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer. J Natl Cancer Inst. 1998;90:1361–1370
- ErbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer. J Natl Cancer Inst. 1998;90:1346–1360
- HER-2 amplification and topoisomerase II alpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin Cancer Res. 2002;8:1107–1116
- Topoisomerase IIa gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Cancer Group Trial 9401. J Clin Oncol. 2006;24:2428–2436
- . Anthracyclines in the treatment of HER2-negative breast cancer. J Natl Cancer Inst. 2008;100:6–8
- De Laurentiis M, Caputo F, Massarelli E, et al. HER2 expression and anthracycline effect: results from the Naples GUN3 randomised trial. Proc Am Assoc Cancer Res 2001:133 [abstract].
- HER2 and responsiveness of breast cancer to adjuvant chemotherapy. New Engl J Med. 2006;354:2103–2111
- Type 1 receptor tyrosine kinase profiles identify patients with enhanced benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trials. J Clin Oncol. 2008;26:5027–5035
- Slamon D, Eiermann W, Robert N, et al. BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC
→
T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC
→
TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2neu positive early breast cancer patients. San Antonio Breast Cancer Sympos 2006:52 [abstract]. - Retrospective analysis of topoisomerase 2a amplification and deletion as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil: Danish Breast Cancer Cooperative Group. J Clin Oncol. 2005;23:7483–7490
- Bartlett JMS, Munro A, Dunn JA, et al. Chromosome 17 polysomy (Ch17) as a predictor of anthracycline response: emerging evidence form the UK NEAT adjuvant breast cancer trial. San Antonio Breast Cancer Sympos 2008:45 [abstract].
- Topoisomerase IIα amplification does not predict benefit from dose–intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013. J Clin Oncol. 2009;21:3430–3436
- Desmedt C, Azambuja E, Larsimont D, et al. Predicting the efficacy of anthracyclines in breast cancer (BC) patients: results of the neoadjuvant TOP trial. Proc Am Soc Clin Oncol 2009:523 [abstract].
- Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci USA. 2008;105:9053–9058
- Di Leo A, Isola J, Piette F, et al. A meta-analysis of phase III trials evaluating the predictive value of HER2 and topoisomerase II alpha in early breast cancer patients treated with CMF or anthracycline-based adjuvant therapy. San Antonio Breast Cancer Sympos 2008:705 [abstract].
- Topoisomerase II alpha gene status and prediction of pathological complete remission after anthracycline-based neoadjuvant chemotherapy in endocrine non-responsive HER2/neu-positive breast cancer. Breast. 2008;17:506–511
- <http://clinicaltrials.gov/ct2/show/NCT00493870>.
- . Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response. Lancet Oncol. 2009;10:267–277
- Ejlertsen B, Jensen M-B, Nielsen KV, et al. TOP2A, TIMP-1 and responsiveness to adjuvant anthracycline containing chemotherapy in high risk breast cancer patients. San Antonio Breast Cancer Sympos 2008:36 [abstract].
- A stroma-related gene signature predicts response to neoadjuvant chemotherapy in breast cancer. Nature Med. 2009;1:68–74
PII: S0305-7372(09)00121-2
doi: 10.1016/j.ctrv.2009.08.006
© 2009 Elsevier Ltd. All rights reserved.
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Cancer Treatment Reviews
Volume 35, Issue 8
, Pages 662-667
, December 2009
