« Previous
Next »
Cancer Treatment Reviews
Volume 35, Issue 7
, Pages 633-638
, November 2009
Trastuzumab versus lapatinib: The cardiac side of the story
References
- . Essential role of Her2/erbB2 in cardiac development and function. Recent Prog Horm Res. 2004;59:1–12
- . Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature. 1995;378:394–398
- . ErbB2 is required for G protein-coupled receptor signaling in the heart. Proc Natl Acad Sci USA. 2006;103:158889–158893
- Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors. Circulation. 1999;100:407–412
- . Targeting Her-2/neu in breast cancer: as easy as this!. Oncology. 2008;74:150–157
- Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783–792
- Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005;353:1659–1672
- Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Eng J Med. 2007;233:2733–2743
- . Anthracycline cardiotoxicity after breast cancer treatment. Oncology (Williston Park). 2009;23:227–234
- . Anthracycline cardiotoxicity: from bench to bedside. J Clin Oncol. 2008;26:3777–3784
- . Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation. 2002;105:1551–1554
- . Herceptin and the heart – a molecular modifier of cardiac failure. N Engl J Med. 2006;354:789–790
- . Cardiac toxicity with anti-HER-2 therapies: what have we learnt so far?. Target Oncol. 2009;4:77–88
- Anthracycline and trastuzumab in breast cancer treatment. Oncology (Williston Park). 2004;18(Suppl. 14):59–64
- . Type II chemotherapy-related cardiac dysfunction: time to recognize a new entity. J Clin Oncol. 2005;23:2900–2902
- Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353:1673–1684
- Spielmann M, Roché H, Humblet Y, Delozier T, Bourgeois H, Serin D, et al. 3-Year follow-up of trastuzumab following adjuvant chemotherapy in node positive HER2-positive breast cancer patients: results of the PACS-04 trial. In: Proceedings of the San Antonio breast cancer symposium, December 13–16, 2007, San Antonio, Texas; 2007 [Abs # 72].
- Slamon D, Eiermann W, Robert N, Pienkowski T, Martin M, Pawlicki M, et al. Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC
→
T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab(AC
→
TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study. In: Proceedings of the San Antonio breast cancer symposium, December 8–11, 2005, San Antonio, Texas [Abs # 1]. - Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol. 2008;26:1231–1238
- . The anthracycline–trastuzumab interaction: up-regulated binding may provide vital mechanistic insight. Eur J Cancer. 2007;43:2024–2025
- Update of the HERA trial and the role of 1 year trastuzumab as adjuvant therapy for breast cancer. Breast. 2009;18(Suppl. 1):S25;[abstract #]
- . Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc. 2008;83:679–686
- Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol. 2008;26:5544–5552
- . Tumour biology: herceptin acts as an antiangiogenic cocktail. Nature. 2002;416:279–280
- Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin Cancer Res. 2004;10:5650–5655
- ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002;8:459–465
- Normal cardiac biopsy results following co-administration of doxorubicin (A), cyclophosphamide (C) and trastuzumab (H) to women with HER2-positive metastatic breast cancer. J Clin Oncol. 2004;23:72;[abstract #]
- Clinical activity of pertuzumab (rhMAB 2C4), a HER dimerization inhibitor, in advanced ovarian activity: potential predictive relationship with tumor HER2 activation status. J Clin Oncol. 2006;24:4324–4332
- Efficacy and safety of single agent pertuzumab (rhuMAB), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy. J Clin Oncol. 2007;25:675–681
- Efficacy and safety of single-agent pertuzumab, a human epidermal receptor dimerization inhibitor, in patients with non small cell lung cancer. Clin Cancer Res. 2007;13:6175–6181
- Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2002;20:719–726
- Phase II study of efficacy, safety, and pharmakinetics of trastuzumab monotherapy administrated on a 3-weekly schedule. J Clin Oncol. 2005;23:2162–2171
- Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol. 2008;26:2999–3005
- Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first-or second-line trastuzumab-containing regimens. Ann Oncol. 2009;20:1026–1031
- PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer. Brit J Cancer. 2006;94:247–252
- Updated biomarker results from a phase II randomized study of lapatinib as first-line treatment for patients with ErbB2-amplified advanced or metastatic breast cancer. Breast Cancer Res Treat. 2006;100(Suppl. 1):S68
- Expression of p95HER2, a truncated for of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst. 2007;99:628–638
- . The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol. 2004;37:449–471
- Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype. Breast Cancer Res Treat. 1999;57:237–243
- NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin Cancer Res. 2002;8:347–353
- Activity of the dual kinase inhibitor lapatnib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res. 2006;66:1630–1639
- A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy. J Clin Oncol. 2008;26:1015;[abstract #]
- Preliminary safety results of dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by weekly paclitaxel (P) with trastuzumab (T) and lapatinib (L) in HER2 overexpressed/amplified breast cancer (BCA). J Clin Oncol. 2008;26:518;[abstract #]
- . Increased intracellular (dATP) enhances cardiac contraction in embryonic chick cardiomyocytes. J Cell Biochem. 2008;104:2217–2227
- . Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells. Cell Cycle. 2008;7:1769–1775
- . High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increased in 5′-AMP-activated protein kinase inhiition of acetyl-CoA carboxylase. J Biol Chem. 1995;270:17513–17520
- Characterization of 5′-AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochim Biophys Acta. 1996;1201:67–75
- Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem. 2001;276:13402–13410
- Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci USA. 2002;99:8880–8885
- Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J Am Coll Cardiol. 2004;44:2231–2238
- . Energy metabolism in the normal and failing heart: potential for therapeutic interventions. Heart Fail Rev. 2002;7:115–130
- Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci USA. 2007;104:10607–10612
- Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2 overexpressing and trastuzumab-treated breast cancer cells. Cancer Res. 2006;66:1630–1639
- . Ca2+- and protein kinase C-dependent signaling pathway for nuclear factor-kappaB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages. J Biol Chem. 2006;281:31337–31347
- . Jumping higher: is it still possible? The ALTTO trial challenge. Expert Rev Anticancer Ther. 2008;8:1883–1890
PII: S0305-7372(09)00094-2
doi: 10.1016/j.ctrv.2009.06.007
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Next »
Cancer Treatment Reviews
Volume 35, Issue 7
, Pages 633-638
, November 2009
