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Cancer Treatment Reviews
Volume 31, Issue 8
, Pages 591-602
, December 2005
Bortezomib, a novel proteasome inhibitor, in the treatment of hematologic malignancies
References
- . Cancer research. Taking garbage in, tossing cancer out. Science. 2002;295(5555):612–613
- . Proteasome inhibition: a novel approach to cancer therapy. Trends Mol Med. 2002;8(4 Suppl):S49–S54
- . The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev. 2002;82(2):373–428
- . Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumour xenografts. Mol Cancer Ther. 2003;2(9):835–843
- . How proteolysis drives the cell cycle. Science. 1996;274(5293):1652–1659
- Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA. 2002;99(22):14374–14379
- . Proteasome inhibition in cancer: development of PS-341. Semin Oncol. 2001;28(6):613–619
- Proteasome inhibitors: a novel class of potent and effective antitumour agents. Cancer Res. 1999;59(11):2615–2622
- . Overcoming drug resistance in multiple myeloma: the emergence of therapeutic approaches to induce apoptosis. J Clin Oncol. 2003;21(22):4239–4247
- . Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin Cancer Res. 2000;6(9):3719–3728
- The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumours in vivo. Mol Cancer Ther. 2004;3(3):279–290
- The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood. 2003;101(6):2377–2380
- . The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Blood. 2003;102(10):3765–3774
- A phase I/II trial of VELCADE and melphalan combination therapy (Vc+M) for patients with relapsed or refractory multiple myeloma (MM). Blood. 2004;104(11):64a
- A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003;348(26):2609–2617
- Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood. 2005;105(8):3058–3065
- . Proteasome inhibition: a new strategy in cancer treatment. Invest New Drugs. 2000;18(2):109–121
- . Proteasome inhibitors as therapeutic agents: current and future strategies. Curr Med Chem. 2003;10(6):479–503
- Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg Med Chem Lett. 1998;8(4):333–338
- . Proteasome inhibitors: from research tools to drug candidates. Chem Biol. 2001;8(8):739–758
- . NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002;2(4):301–310
- . TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science. 1996;274(5288):784–787
- . Control of inducible chemoresistance: enhanced anti-tumour therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med. 1999;5(4):412–417
- Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. 2001;61(9):3535–3540
- Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Int J Radiat Oncol Biol Phys. 2001;50(1):183–193
- The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001;61(7):3071–3076
- Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood. 2003;101(4):1530–1534
- The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumour cells to chemotherapeutic agents. Clin Cancer Res. 2003;9(3):1136–1144
- Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res. 2002;62(17):4996–5000
- . Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J Immunol. 2003;171(1):88–95
- Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res. 2003;63(19):6174–6177
- . Tumour growth inhibition induced in a murine model of human Burkitt’s lymphoma by a proteasome inhibitor. Cancer Res. 1998;58(19):4342–4348
- A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumour malignancies. Clin Cancer Res. 2002;8(8):2505–2511
- Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol. 2002;20(22):4420–4427
- Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumours with observations in androgen-independent prostate cancer. J Clin Oncol. 2004;22:2108–2121
- . Proteasome inhibition measurements: clinical application. Clin Chem. 2000;46(5):673–683
- . Development of the proteasome inhibitor PS-341. Oncologist. 2002;7(1):9–16
- Survival, duration of response, and time to progression with bortezmib in patients with relapsed and refractory multiple myeloma: an update with additional follow-up. Hematol J. 2004;5(Suppl 2):S103–S104
- The safety of prolonged therapy with the proteasome inhibitor bortezomib (VELCADE) in relapsed and/or refractory multiple myeloma (MM). Hematol J. 2004;5(Suppl 2):S129
- A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol. 2004;127(2):165–172
- Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005;352(24):2487–2498
- Bortezomib at first relapse is superior to high-dose dexamethasone and mnore effective than when given later in relapsed multiple myeloma. Haematologica. 2005;90(Suppl 1):s1–s2
- Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma. Hematol J. 2004;5(Suppl 2):S130
- Bortezomib Velcade™)
+
Adriamycin™
+
thalidomide
+
dexamethasone (VATD) as an effective regimen in patients with refractory or relapsed multiple myeloma (MM). Blood. 2004;104(11):659a - A phase II study of Velcade (V), Doxil (D) in combination with low-dose thalidomide (T) as salvage therapy for patients (pts) with relapsed (rel) or refractory (ref) multiple myeloma (MM) and Waldenstrom’s macroglobulinemia (WM): encouraging preliminary results. Blood. 2004;104(11):665a–666a
- Marked activity of Velcade plus thalidomide (V
+
T) in advanced and refractory multiple myeloma (MM). Blood. 2004;104(11):413a–414a - Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol. 2005;129(6):776–783
- PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol. 2005;129(6):755–762
- Bortezomib (VELCADE) plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: preliminary results of an IFM phase II study. J Clin Oncol. 2005;23(16S):598s
- . VTD (Velcade, thalidomide, dexamethasone) as primary therapy for newly-diagnosed multiple myeloma. Blood. 2004;104(11):64a
- A phase I/II national, multi-center, open-label study of Velcade plus melphalan and prednisone (V-MP) in elderly untreated multiple myeloma patients. Haematologica. 2005;90(Suppl 1):149
- Bortezomib in recurrent and/or refractory multiple myeloma: initial clinical experience in patients with impaired renal function. Cancer. 2005;103(6):1195–1200
- VELCADE (bortezomib) for injection. Full prescribing information available at: http://www.millenniumcom/products/velcade/indexasp; 2004. Accessed February 24, 2005.
- Characterization and reversibility of peripheral neuropathy in patients with advanced multiple myeloma treated with bortezomib (VELCADE): the SUMMIT and CREST study group. Hematol J. 2004;5(2):S129
- Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin’s lymphoma. J Clin Oncol. 2005;23(4):667–675
- Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin’s lymphoma and mantle cell lymphoma. J Clin Oncol. 2005;23(4):676–684
- Phase II trial of bortezomib in mantle cell lymphoma. Blood. 2004;104(11):175a
- Phase II clinical study of bortezomib (VELCADE®) in patients (pts) with relapsed/refractory non-Hodgkin’s lymphoma (NHL) and Hodgkin’s disease (HD). Blood. 2004;104(11):389a
- Phase I/II study of bortezomib alone and bortezomib with dose-adjusted EPOCH chemotherapy in relapsed or refractory aggressive B-Cell lymphoma. Blood. 2004;104(11):389a
- . Safety and efficacy of bortezomib (VELCADE®) for the treatment of relapsed classical Hodgkin’s disease. Blood. 2004;104(11):722a
- Phase I study of bortezomib in refractory or relapsed acute leukemias. Clin Cancer Res. 2004;10(10):3371–3376
- . Phase I dose-escalating trial of bortezomib (VELCADE®) in combination with idarubicin and cytosine arabinoside in patients with acute myeloid leukemia. Blood. 2004;104(11):498a
- . Cost effectiveness of bortezomib in the treatment of advanced multiple myeloma. Manag Care Interface. 2004;17(9):52–61
- Economic evaluation of bortezomib (Velcade) for relapsed and refractory multiple myeloma. Blood. 2004;104(11):80a
- . How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations. CMAJ. 1992;146(4):473–481
- . Efficacy, safety, and cost of new anticancer drugs. BMJ. 2005;325:1302
- Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. Blood. 2001;98(2):492–494
- . Phase 2 study of arsenic trioxide in patients with relapsed or refractory multiple myeloma. Br J Haematol. 2004;125(4):470–476
- Delayed stem cell transplantation for the management of relapsed or refractory multiple myeloma. Bone Marrow Transplant. 2000;26(1):45–50
- Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998;102(5):1115–1123
PII: S0305-7372(05)00199-4
doi: 10.1016/j.ctrv.2005.10.001
© 2005 Elsevier Ltd. All rights reserved.
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Cancer Treatment Reviews
Volume 31, Issue 8
, Pages 591-602
, December 2005
