Cancer Treatment Reviews
Volume 31, Issue 6 , Pages 448-455 , October 2005

The role of pentoxifylline as a modifier of radiation therapy

References 

  1. Sliwa K, Woodiwiss A, Kone VN, et al. Therapy of ischemic cardiomyopathy with the immunomodulating agent pentoxifylline: results of a randomized study. Circulation. 2004;109:750–755
  2. Hong JH, Chiang CS, Campbell IL, Sun JR, Withers HR, McBride WH. Induction of acute phase gene expression by brain irradiation. Int J Radiat Oncol Biol Phys. 1995;33:619–626
  3. Theron T, Binder A, Verheye-Dua F, Bohm L. The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline. Int J Radiat Biol. 2000;76:1197–1208
  4. Binder A, Theron T, Donninger H, Parker M, Bohm L. Radiosensitization and DNA repair inhibition by pentoxifylline in NIH3T3 p53 transfectants. Int J Radiat Biol. 2002;78:991–1000
  5. Li YX, Weber-Johnson K, Sun LQ, Paschoud N, Mirimanoff RO, Coucke PA. Effect of pentoxifylline on radiation-induced G2-phase delay and radiosensitivity of human colon and cervical cancer cells. Radiat Res. 1998;149:338–342
  6. Strunz AM, Peschke P, Waldeck W, Ehemann V, Kissel M, Debus J. Preferential radiosensitization in p53-mutated human tumour cell lines by pentoxifylline-mediated disruption of the G2/M checkpoint control. Int J Radiat Biol. 2002;78:721–732
  7. Geldof AA, Plaizier MA, Duivenvoorden I, et al. Cell cycle perturbations and radiosensitization effects in a human prostate cancer cell line. J Cancer Res Clin Oncol. 2003;129:175–182
  8. Eley KW, Benedict SH, Chung TD, et al. The effects of pentoxifylline on the survival of human glioma cells with continuous and intermittent stereotactic radiosurgery irradiation. Int J Radiat Oncol Biol Phys. 2002;54:542–550
  9. Lee I, Biaglow JE, Lee J, Cho MJ. Physiological mechanisms of radiation sensitization by pentoxifylline. Anticancer Res. 2000;20:4605–4609
  10. Collingridge DR, Rockwell S. Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas. Int J Cancer. 2000;90:256–264
  11. Zywietz F, Bohm L, Sagowski C, Kehrl W. Pentoxifylline enhances tumor oxygenation and radiosensitivity in rat rhabdomyosarcomas during continuous hyperfractionated irradiation. Strahlenther Onkol. 2004;180:306–314
  12. Wakasa T, Kawai N, Yanagi Y, Hayase Y, Kishi K. A study of hypoxic cell radiosensitizer applied to Ehrlich ascite tumour: a comparison of FC43 emulsion and pentoxyfilline. Br J Radiol. 2002;75:909–912
  13. Johnson FE, Harrison BR, McKirgan LW, Raju PI, Roy TK, Virgo KS. A phase II evaluation of pentoxifylline combined with radiation in the treatment of brain metastases. Int J Oncol. 1998;13:801–805
  14. Stewart DJ, Dahrouge S, Agboola O, Girard A. Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas. J Neurooncol. 1997;32:161–168
  15. Kwon HC, Kim SK, Chung WK, et al. Effect of pentoxifylline on radiation response of non-small cell lung cancer: a phase III randomized multicenter trial. Radiother Oncol. 2000;56:175–179
  16. Ward WF, Kim YT, Molteni A, et al. Pentoxifylline does not spare acute radiation reactions in rat lung and skin. Radiat Res. 1992;129:107–111
  17. Koh WJ, Stelzer KJ, Peterson LM, et al. Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats. Int J Radiat Oncol Biol Phys. 1995;31:71–77
  18. Rube CE, Wilfert F, Uthe D, et al. Modulation of radiation-induced tumour necrosis factor alpha (TNF-alpha) expression in the lung tissue by pentoxifylline. Radiother Oncol. 2002;64:177–187
  19. Stelzer KJ, Koh WJ, Peterson LM, Griffin TW. Effect of high-dose pentoxifylline on acute radiation-induced lung toxicity in a rat lung perfusion model. Int J Radiat Oncol Biol Phys. 1996;34:111–115
  20. Damron TA, Spadaro JA, Horton JA, Margulies BS, Strauss JA, Farnum CE. Novel radioprotectant drugs for sparing radiation-induced damage to the physis. Int J Radiat Biol. 2004;80:217–228
  21. Lefaix JL, Delanian S, Vozenin MC, Leplat JJ, Tricaud Y, Martin M. Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study. Int J Radiat Oncol Biol Phys. 1999;43:839–847
  22. Ozturk B, Egehan I, Atavci S, Kitapci M. Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial. Int J Radiat Oncol Biol Phys. 2004;58:213–219
  23. Aygenc E, Celikkanat S, Kaymakci M, Aksaray F, Ozdem C. Prophylactic effect of pentoxifylline on radiotherapy complications: a clinical study. Otolaryngol Head Neck Surg. 2004;130:351–356
  24. Dion MW, Hussey DH, Doornbos JF, Vigliotti AP, Wen BC, Anderson B. Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. Int J Radiat Oncol Biol Phys. 1990;19:401–407
  25. Futran ND, Trotti A, Gwede C. Pentoxifylline in the treatment of radiation-related soft tissue injury: preliminary observations. Laryngoscope. 1997;107:391–395
  26. Chua DT, Lo C, Yuen J, Foo YC. A pilot study of pentoxifylline in the treatment of radiation-induced trismus. Am J Clin Oncol. 2001;24:366–369
  27. Okunieff P, Augustine E, Hicks JE, et al. Pentoxifylline in the treatment of radiation-induced fibrosis. J Clin Oncol. 2004;22:2207–2213
  28. Prasad KN, Cole WC, Kumar B, Che Prasad K. Pros and cons of antioxidant use during radiation therapy. Cancer Treat Rev. 2002;28:79–91
  29. Letur-Konirsch H, Guis F, Delanian S. Uterine restoration by radiation sequelae regression with combined pentoxifylline-tocopherol: a phase II study. Fertil Steril. 2002;77:1219–1226
  30. Delanian S, Porcher R, Balla-Mekias S, Lefaix JL. Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis. J Clin Oncol. 2003;21:2545–2550
  31. Gothard L, Cornes P, Earl J, et al. Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer. Radiother Oncol. 2004;73:133–139
  32. Delanian S, Lefaix JL. The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol. 2004;73:119–131

PII: S0305-7372(05)00127-1

doi: 10.1016/j.ctrv.2005.07.007

Cancer Treatment Reviews
Volume 31, Issue 6 , Pages 448-455 , October 2005