Cancer Treatment Reviews
Volume 31, Issue 7 , Pages 555-570 , November 2005

Radiation recall: A well recognized but neglected phenomenon

  • David Azria

      Affiliations

    • Department of Radiation Oncology, Val d’Aurelle-Paul Lamarque Cancer Institute, Montpellier, France
    • Tumor Immunotargeting and Antibody Engineering, EMI 0227, Montpellier, France
    • ,
  • Nicolas Magné

      Affiliations

    • Département de Radiothérapie, Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: + 32 2 541 3825; fax: + 32 2 538 7542.
    • ,
  • Abderrahim Zouhair

      Affiliations

    • Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • ,
  • Pierre Castadot

      Affiliations

    • Département de Radiothérapie, Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium
    • ,
  • Stéphane Culine

      Affiliations

    • Department of Medical Oncology, Val d’Aurelle-Paul Lamarque Cancer Institute, Montpellier, France
    • ,
  • Marc Ychou

      Affiliations

    • Department of Medical Oncology, Val d’Aurelle-Paul Lamarque Cancer Institute, Montpellier, France
    • ,
  • Roger Stupp

      Affiliations

    • Department of Medical Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • ,
  • Paul Van Houtte

      Affiliations

    • Département de Radiothérapie, Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium
    • ,
  • Jean-Bernard Dubois

      Affiliations

    • Department of Radiation Oncology, Val d’Aurelle-Paul Lamarque Cancer Institute, Montpellier, France
    • ,
  • Mahmut Ozsahin

      Affiliations

    • Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

References 

  1. Tan CTC, Dargeon HW, Burchenal JH. The effect of actinomycin D on cancer in childhood. Pediatrics. 1959;24:544–561
  2. D’Angio GJ. Clinical and biologic studies of actinomycin D and roentgen irradiation. Am J Roentgenol. 1962;87:106–109
  3. Donaldson SS, Glick JM, Wilbur JR. Letter: adriamycin activating a recall phenomenon after radiation therapy. Ann Intern Med. 1974;81:407–408
  4. Etcubanas E, Wilbur JR. Letter: uncommon side effects of adriamycin (NSC-123127). Cancer Chemother Rep. 1974;58:757–758
  5. Cassady JR, Richter MP, Piro AJ, et al. Radiation-adriamycin interactions: preliminary clinical observations. Cancer. 1975;36:946–949
  6. Mayer EG, Poulter CA, Aristizabal SA. Complications of irradiation related to apparent drug potentiation by adriamycin. Int J Radiat Oncol Biol Phys. 1976;1:1179–1188
  7. Solberg LA, Wick MR, Bruckman JE. Doxorubicin-enhanced skin reaction after whole-body electron-beam irradiation for leukemia cutis. Mayo Clin Proc. 1980;55:711–715
  8. Kellie SJ, Plowman PN, Malpas JS. Radiation recall and radiosensitization with alkylating agents. Lancet. 1987;1:1149–1150
  9. Jaffe N, Paed D, Farber S, et al. Favorable response of metastatic osteogenic sarcoma to pulse high-dose methotrexate with citrovorum rescue and radiation therapy. Cancer. 1973;31:1367–1373
  10. Rosen G, Tefft M, Martinez A, et al. Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma. Cancer. 1975;35:622–630
  11. Kharfan Dabaja MA, Morgensztern D, Markoe AM, et al. Radiation recall dermatitis induced by methotrexate in a patient with Hodgkin’s disease. Am J Clin Oncol. 2000;23:531–533
  12. Von Essen CF, Kligerman MM, Calabresi P. Radiation and 5-fluorouracil: a controlled clinical study. Radiology. 1963;81:1018–1026
  13. Bar-Sela G, Beny A, Bergman R, et al. Gemcitabine-induced radiation recall dermatitis: case report. Tumori. 2001;87:428–430
  14. Ganem G, Solal-Celigny P, Joffroy A, et al. Radiation myositis: the possible role of gemcitabine. Ann Oncol. 2000;11:1615–1616
  15. Jeter MD, Janne PA, Brooks S, et al. Gemcitabine-induced radiation recall. Int J Radiat Oncol Biol Phys. 2002;53:394–400
  16. Yeo W, Leung SF, Johnson PJ. Radiation-recall dermatitis with docetaxel: establishment of a requisite radiation threshold. Eur J Cancer. 1997;33:698–699
  17. Camidge DR, Kunkler IH. Docetaxel-induced radiation recall dermatitis and successful rechallenge without recurrence. Clin Oncol. 2000;12:272–273
  18. Morkas M, Fleming D, Hahl M. Challenges in oncology. Case 2. Radiation recall associated with docetaxel. J Clin Oncol. 2002;20:867–869
  19. Shenkier T, Gelmon K. Paclitaxel and radiation-recall dermatitis. J Clin Oncol. 1994;12:439
  20. Raghavan VT, Bloomer WD, Merkel DE. Taxol and radiation recall dermatitis. Lancet. 1993;341:1354
  21. Phillips KA, Urch M, Bishop JF. Radiation-recall dermatitis in a patient treated with paclitaxel. J Clin Oncol. 1995;13:305
  22. McCarty MJ, Peake MF, Lillis P, et al. Paclitaxel-induced radiation recall dermatitis. Med Pediatr Oncol. 1996;27:185–186
  23. Schweitzer VG, Juillard GJ, Bajada CL, et al. Radiation recall dermatitis and pneumonitis in a patient treated with paclitaxel. Cancer. 1995;76:1069–1072
  24. Bokemeyer C, Lampe C, Heneka M, et al. Paclitaxel-induced radiation recall dermatitis. Ann Oncol. 1996;7:755–756
  25. Extermann M, Vogt N, Forni M, et al. Radiation recall in a patient with breast cancer treated for tuberculosis. Eur J Clin Pharmacol. 1995;48:77–78
  26. Garza LA, Yoo EK, Junkins-hopkins JM, VanVoorhees AS. Photo recall effect in association with cefazolin. Cutis. 2004;73:79–85
  27. Parry BR. Radiation recall induced by tamoxifen. Lancet. 1992;340:49
  28. Bostrom A, Sjolin-Forsberg G, Wilking N, et al. Radiation recall–another call with tamoxifen. Acta Oncol. 1999;38:955–959
  29. Singer EA, Warren RD, Pennanen MF, Collins BT, Hayes DF. Tamoxifen-induced radiation recall dermatitis. Breast J. 2004;10:170–171
  30. Abadir R, Liebmann J. Radiation reaction recall following simvastatin therapy: a new observation. Clin Oncol. 1995;7:325–326
  31. Del Guidice SM, Gerstley JK. Sunlight-induced radiation recall. Int J Dermatol. 1988;27:415–416
  32. Halliday GM, Byrne SN, Kuchel JM, et al. The suppression of immunity by ultraviolet radiation : UVA, nitric oxide and DNA damage. Photochem Photobiol Sci. 2004;3:736–740
  33. Ristic B. Radiation recall dermatitis. Int J Dermatol. 2004;43:627–631
  34. Ma LD, Taylor GA, Wharam MD, et al. “Recall” pneumonitis: adriamycin potentiation of radiation pneumonitis in two children. Radiology. 1993;187:465–467
  35. McLnerney DP, Bullimore J. Reactivation of radiation pneumonitis by adriamycin. Br J Radiol. 1977;50:224–227
  36. Showel J, Hoover SV, Deutsch S. Radiation-recall. Int J Radiat Oncol Biol Phys. 1993;25:929
  37. Stein RS. Radiation-recall enteritis after actinomycin-D and adriamycin therapy. South Med J. 1978;71:960–961
  38. Kundak I, Oztop I, Soyturk M, et al. Paclitaxel-carboplatin induced radiation recall colitis. Tumori. 2004;90:256–258
  39. Borroni G, Vassallo C, Brazzelli V, et al. Radiation recall dermatitis, panniculitis, and myositis following cyclophosphamide therapy: histopathologic findings of a patient affected by multiple myeloma. Am J Dermatopathol. 2004;26:213–216
  40. Culp LR, Pou AM, Jones DV, et al. A case of radiation recall mucositis associated with docetaxel. Head Neck. 2004;26:197–200
  41. Wallenborn PA, Postma DS. Radiation recall supraglottitis. A hazard in head and neck chemotherapy. Arch Otolaryngol. 1984;110:614–617
  42. Wiatrak BJ, Myer CM. Radiation recall supraglottitis in a child. Am J Otolaryngol. 1991;12:227–229
  43. Vegesna V, Withers HR, McBride WH, Holly FE. Adriamycin-induced recall of radiation pneumonitis and epilation in lung and hair follicles of mouse. Int J Radiat Oncol Biol Phys. 1992;23:977–981
  44. Hellman S, Botnick LE. Stem cell depletion: an explanation of the late effects of cytotoxins. Int J Radiat Oncol Biol Phys. 1977;2:181–184
  45. Seymour CB, Mothersill C, Alper T. High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int J Radiat Biol Relat Stud Phys Chem Med. 1986;50:167–179
  46. Kitani H, Kosaka T, Fujihara T, et al. The “recall effect” in radiotherapy: is subeffective, reparable damage involved?. Int J Radiat Oncol Biol Phys. 1990;18:689–695
  47. Camidge R, Price A. Characterizing the phenomenon of radiation recall dermatitis. Radiother Oncol. 2001;59:237–245
  48. James WD, Odom RB. Late subcutaneous fibrosis following megavoltage radiotherapy. J Am Acad Dermatol. 1980;3:616–618
  49. Johnston CJ, Piedboeuf B, Rubin P, et al. Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumour necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res. 1996;145:762–767
  50. Vozenin-Brotons MC, Gault N, Sivan V, et al. Histopathological and cellular studies of a case of cutaneous radiation syndrome after accidental chronic exposure to a cesium source. Radiat Res. 1999;152:332–337
  51. Hallahan DE, Spriggs DR, Beckett MA, et al. Increased tumour necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci USA. 1989;86:10104–10107
  52. Nemechek PM, Corder MC. Radiation recall associated with vinblastine in a patient treated for Kaposi sarcoma related to acquired immune deficiency syndrome. Cancer. 1992;70:1605–1606
  53. Camidge R, Price A. Radiation recall dermatitis may represent the koebner phenomenon. J Clin Oncol. 2002;20:4130
  54. Jacot W, Bessis D, Jorda E, et al. Acneiform eruption induced by epidermal growth factor receptor inhibitors in patients with solid tumors. Br J Dermatol. 2004;151:238
  55. Busam KJ, Capodieci P, Motzer R, et al. Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br J Dermatol. 2001;144:1169–1176
  56. Williams BJ, Roth DJ, Callen JP. Ultraviolet recall associated with etoposide and cyclophosphamide therapy. Clin Exp Dermatol. 1993;18:452–453
  57. Trotti A, Byhardt R, Stetz J, et al. Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47:13–47
  58. Trotti A, Chin LJ. Adverse effects: a Pandora’s box for oncology. Int J Radiat Oncol Biol Phys. 2002;54:642–646
  59. Chan RT, Au GK, Ho JW, et al. Radiation recall with oxaliplatin: report of a case and a review of the literature. Clin Oncol. 2001;13:55–57
  60. Burdon J, Bell R, Sullivan J, et al. Adriamycin-induced recall phenomenon 15 years after radiotherapy. Jama. 1978;239:931
  61. D’Angio GJ, Farber S, Maddock CL. Potentiation of X-ray effects of actinomycin D. Radiology. 1959;73:175–177
  62. Fontana JA. Radiation recall associated with VP-16-213 therapy. Cancer Treat Rep. 1979;63:224–225
  63. Eifel PJ, McClure S. Severe chemotherapy-induced recall of radiation mucositis in a patient with non-Hodgkin’s lymphoma of Waldeyer’s ring. Int J Radiat Oncol Biol Phys. 1989;17:907–908
  64. Bronner AK, Hood AF. Cutaneous complications of chemotherapeutic agents. J Am Acad Dermatol. 1983;9:645–663
  65. Smith KJ, Germain M, Skelton H. Histopathologic Features Seen with Radiation Recall or Enhancement Eruptions. J Cutan Med Surg. 2002;9:9
  66. Stelzer KJ, Griffin TW, Koh WJ. Radiation recall skin toxicity with bleomycin in a patient with Kaposi sarcoma related to acquired immune deficiency syndrome. Cancer. 1993;71:1322–1325
  67. Ortmann E, Hohenberg G. Treatment side effects. Case 1. Radiation recall phenomenon after administration of capecitabine. J Clin Oncol. 2002;20:3029–3030
  68. Kennedy RD, McAleer JJ. Radiation recall dermatitis in a patient treated with dacarbazine. Clin Oncol. 2001;13:470–472
  69. Piroth MD, Krempien R, Wannenmacher M, et al. Radiation recall dermatitis from docetaxel. Onkologie. 2002;25:438–440
  70. Perez EA, Campbell DL, Ryu JK. Radiation recall dermatitis induced by edatrexate in a patient with breast cancer. Cancer Invest. 1995;13:604–607
  71. Burstein HJ. Side effects of chemotherapy. Case 1. Radiation recall dermatitis from gemcitabine. J Clin Oncol. 2000;18:693–694
  72. Castellano D, Hitt R, Cortes-Funes H, et al. Side effects of chemotherapy. Case 2. Radiation recall reaction induced by gemcitabine. J Clin Oncol. 2000;18:695–696
  73. Sears ME. Erythema in areas of previous irradiation in patients treated with hydroxyurea (NSC-32065). Cancer Chemother Rep. 1964;40:31–32
  74. Thomas R, Stea B. Radiation recall dermatitis from high-dose interferon alfa-2b. J Clin Oncol. 2002;20:355–357
  75. Weiss RB, James WD, Major WB, et al. Skin reactions induced by trimetrexate, an analog of methotrexate. Invest New Drugs. 1986;4:159–163
  76. Jolivet J, Landry L, Pinard MF, et al. A phase I study of trimetrexate, an analog of methotrexate, administered monthly in the form of nine consecutive daily bolus injections. Cancer Chemother Pharmacol. 1987;20:169–172
  77. Lampkin BC. Skin reaction to vinblastine. Lancet. 1969;1:891
  78. Zulian GB, Aapro MS. Docetaxel and radiation-recall severe mucositis. Ann Oncol. 1994;5:964
  79. Hill AB, Tattersall SF. Recall of radiation pneumonitis after intrapleural administration of doxorubicin. Med J Aust. 1983;1:39–40
  80. Gabel C, Eifel PJ, Tornos C, Burke TW. Radiation recall reaction to idarubicin resulting in vaginal necrosis. Gynecol Oncol. 1995;57:266–269

PII: S0305-7372(05)00126-X

doi: 10.1016/j.ctrv.2005.07.008

Cancer Treatment Reviews
Volume 31, Issue 7 , Pages 555-570 , November 2005

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