Cancer Treatment Reviews
Volume 30, Issue 8 , Pages 671-682 , December 2004

Radiotherapy for breast cancer in patients undergoing breast reconstruction or augmentation

  • Elżbieta Senkus-Konefka

      Affiliations

    • Department of Oncology and Radiotherapy, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland
    • Corresponding Author InformationCorresponding author. Tel.: +48-58-3492271; fax: +48-58-3492270
    • ,
  • Marzena Wełnicka-Jaśkiewicz

      Affiliations

    • Department of Oncology and Radiotherapy, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland
    • ,
  • Janusz Jaśkiewicz

      Affiliations

    • Department of Plastic Surgery, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland
    • ,
  • Jacek Jassem

      Affiliations

    • Department of Oncology and Radiotherapy, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland

References 

  1. Malata CM, McIntosh SA, Purushotham AD. Immediate breast reconstruction after mastectomy for cancer. Br. J. Surg. 2000;87:1455–1472
  2. Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N. Engl. J. Med. 1997;337:949–955
  3. Ragaz J, Jackson SM, Le N, Plenderleith IH, Spinelli JJ, Basco VE, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N. Engl. J. Med. 1997;337:956–962
  4. Spear SL, Onyewu C. Staged breast reconstruction with saline-filled implants in the irradiated breast: recent trends and therapeutic implications. Plast. Reconstr. Surg. 2000;105:930–942
  5. Kuske RR, Schuster R, Klein E, Young L, Perez CA, Fineberg B. Radiotherapy and breast reconstruction: clinical results and dosimetry. Int. J. Radiat. Oncol. Biol. Phys. 1991;21:339–346
  6. Recht A, Edge SB, Solin LJ, Robinson DS, Estabrook A, Fine RE, et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J. Clin. Oncol. 2001;19:1539–1569
  7. Stabile RJ, Santoro E, Dispaltro F, Sanfilippo LJ. Reconstructive breast surgery following mastectomy and adjunctive radiation therapy. Cancer. 1980;45:2738–2743
  8. Noguchi M, Fukushima W, Ohta N, Koyasaki N, Thomas M, Miyazaki I, et al. Oncological aspect of immediate breast reconstruction in mastectomy patients. J. Surg. Oncol. 1992;50:241–246
  9. Noone RB, Frazier TG, Noone GC, Blanchet NP, Murphy JB, Rose D. Recurrence of breast carcinoma following immediate reconstruction: a 13-year review. Plast. Reconstr. Surg. 1994;93:96–106
  10. Corral CJ, Mustoe TA. Controversy in breast reconstruction. Surg. Clin. North Am. 1996;76:309–326
  11. O’Brien W, Hasselgren PO, Hummel RP, Coith R, Hyams D, Kurtzman L, et al. Comparison of postoperative wound complications and early cancer recurrence between patients undergoing mastectomy with or without immediate breast reconstruction. Am. J. Surg. 1993;166:1–5
  12. Proulx GM, Loree T, Edge S, Hurd T, Stomper P. Outcome with postmastectomy radiation with transverse rectus abdominis musculocutaneous flap breast reconstruction. Am. Surg. 2002;68:410–413
  13. Hanks SH, Lyons JA, Crowe J, Lucas A, Yetman RJ. The acute effects of postoperative radiation therapy on the transverse rectus abdominis myocutaneous flap used in immediate breast reconstruction. Int. J. Radiat. Oncol. Biol. Phys. 2000;47:1185–1190
  14. Yule GJ, Concannon MJ, Croll G, Puckett CL. Is there liability with chemotherapy following immediate breast construction?. Plast. Reconstr. Surg. 1996;97:969–973
  15. Discussion. Ann Surg 1995;221:764–6
  16. Hartrampf CR, Bennett GK. Autogenous tissue reconstruction in the mastectomy patient. A critical review of 300 patients. Ann. Surg. 1987;205:508–519
  17. Tran NV, Chang DW, Gupta A, Kroll SS, Robb GL. Comparison of immediate and delayed free TRAM flap breast reconstruction in patients receiving postmastectomy radiation therapy. Plast. Reconstr. Surg. 2001;108:78–82
  18. Scheflan M, Dinner MI. The transverse abdominal island flap: part I. Indications, contraindications, results, and complications. Ann. Plast. Surg. 1983;10:24–35
  19. Olenius M, Jurell G. Breast reconstruction using tissue expansion. Scand. J. Plast. Reconstr. Surg. Hand Surg. 1992;26:83–90
  20. Spear SL, Majidian A. Immediate breast reconstruction in two stages using textured, integrated-valve tissue expanders and breast implants: a retrospective review of 171 consecutive breast reconstructions from 1989 to1996. Plast. Reconstr. Surg. 1998;101:53–63
  21. Chawla AK, Kachnic LA, Taghian AG, Niemierko A, Zapton DT, Powell SN. Radiotherapy and breast reconstruction: complications and cosmesis with TRAM versus tissue expander/implant. Int. J. Radiat. Oncol. Biol. Phys. 2002;54:520–526
  22. Krueger EA, Wilkins EG, Strawderman M, Cederna P, Goldfarb S, Vicini FA, et al. Complications and patient satisfaction following expander/implant breast reconstruction with and without radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2001;49:713–721
  23. Tran NV, Evans GR, Kroll SS, Baldwin BJ, Miller MJ, Reece GP, et al. Postoperative adjuvant irradiation: effects on tranverse rectus abdominis muscle flap breast reconstruction. Plast. Reconstr. Surg. 2000;106:313–317
  24. Rogers NE, Allen RJ. Radiation effects on breast reconstruction with the deep inferior epigastric perforator flap. Plast. Reconstr. Surg. 2002;109:1919–1924
  25. Buchholz TA, Strom EA, Perkins GH, McNeese MD. Controversies regarding the use of radiation after mastectomy in breast cancer. Oncologist. 2002;7:539–546
  26. Shankar RA, Nibhanupudy JR, Sridhar R, Ashton C, Goldson AL. Immediate breast reconstruction-impact on radiation management. J. Natl. Med. Assoc. 2003;95:286–295
  27. Mehta VK, Goffinet D. Postmastectomy radiation therapy after TRAM flap breast reconstruction. Breast J. 2004;10:118–122
  28. Chu FC, Kaufmann TP, Dawson GA, Kim YS, Rajaratnam S, Hoffman LA. Radiation therapy of cancer in prosthetically augmented or reconstructed breasts. Radiology. 1992;185:429–433
  29. McGinley PH, Powell WR, Bostwick J. Dosimetry of a silicone breast prosthesis. Radiology. 1980;135:223–224
  30. Klein EE, Kuske RR. Changes in photon dose distributions due to breast prostheses. Int. J. Radiat. Oncol. Biol. Phys. 1993;25:541–549
  31. Moni J, Graves-Ditman M, Cederna P, Griffith K, Krueger EA, Fraass BA, et al. Dosimetry around metallic ports in tissue expanders in patients receiving postmastectomy radiation therapy: an ex vivo evaluation. Med. Dosim. 2004;29:49–54
  32. Krishnan L, Krishnan EC. Electron beam irradiation after reconstruction with silicone gel implant in breast cancer. Am. J. Clin. Oncol. 1986;9:223–226
  33. Piontek RW, Kase KR. Radiation transmission study of silicone elastomer for mammary prosthesis. Radiology. 1980;136:505–507
  34. Shedbalkar AR, Devata A, Padanilam T. A study of effects of radiation on silicone prostheses. Plast. Reconstr. Surg. 1980;65:805–810
  35. Handel N, Lewinsky B, Silverstein MJ, Gordon P, Zierk K. Conservation therapy for breast cancer following augmentation mammaplasty. Plast. Reconstr. Surg. 1991;87:873–878
  36. Moran SL, Serletti JM, Fox I. Immediate free TRAM reconstruction in lumpectomy and radiation failure patients. Plast. Reconstr. Surg. 2000;106:1527–1531
  37. Evans GR, David CL, Loyer EM, Strom E, Waldron C, Ortega R, et al. The long-term effects of internal mammary chain irradiation and its role in the vascular supply of the pedicled transverse rectus abdominis musculocutaneous flap breast reconstruction. Ann. Plast. Surg. 1995;35:342–348
  38. Robinson DW. Surgical problems in the excision and repair of radiated tissue. Plast. Reconstr. Surg. 1975;55:41–49
  39. Chuang VP. Radiation-induced arteritis. Semin. Roentgenol. 1994;29:64–69
  40. Kurul S, Dincer M, Kizir A, Uzunismail A, Darendeliler E. Plastic surgery in irradiated areas: analysis of 200 consecutive cases. Eur. J. Surg. Oncol. 1997;23:48–53
  41. Rudolph R, Vande BJ, Schneider JA, Fisher JC, Poolman WL. Slowed growth of cultured fibroblasts from human radiation wounds. Plast. Reconstr. Surg. 1988;82:669–677
  42. Ariyan S, Marfuggi RA, Harder G, Goodie MM. An experimental model to determine the effects of adjuvant therapy on the incidence of postoperative wound infection: I. Evaluating preoperative radiation therapy. Plast. Reconstr. Surg. 1980;65:328–337
  43. Cruz NI, Ariyan S, Miniter P, Andriole VT. An experimental model to determine the level of antibiotics in irradiated tissues. Plast. Reconstr. Surg. 1984;73:811–817
  44. Aitasalo K, Aro H. Irradiation-induced hypoxia in bones and soft tissues: an experimental study. Plast. Reconstr. Surg. 1986;77:256–267
  45. Kroll SS, Robb GL, Reece GP, Miller MJ, Evans GR, Baldwin BJ, et al. Does prior irradiation increase the risk of total or partial free-flap loss?. J. Reconstr. Microsurg. 1998;14:263–268
  46. Williams JK, Bostwick J, Bried JT, Mackay G, Landry J, Benton J. TRAM flap breast reconstruction after radiation treatment. Ann. Surg. 1995;221:756–764
  47. Benediktsson K, Perbeck L. The influence of radiotherapy on skin circulation of the breast after subcutaneous mastectomy and immediate reconstruction. Br. J. Plast. Surg. 1999;52:360–364
  48. Clarke HM, Howard CR, Pynn BR, McKee NH. Delayed neovascularization in free skin flap transfer to irradiated beds in rats. Plast. Reconstr. Surg. 1985;75:560–564
  49. Watterson PA, Bostwick J, Hester TR, Bried JT, Taylor GI. TRAM flap anatomy correlated with a10-year clinical experience with 556 patients. Plast. Reconstr. Surg. 1995;95:1185–1194
  50. Contant CM, Van Geel AN, van der HB, Griep C, Tjong Joe WR, Wiggers T. Morbidity of immediate breast reconstruction (IBR) after mastectomy by a subpectorally placed silicone prosthesis: the adverse effect of radiotherapy. Eur. J. Surg. Oncol. 2000;26:344–350
  51. Spear S, Maxwell G. Discussion. Plast. Reconstr. Surg. 1995;96:1116–1118
  52. Ramon Y, Ullmann Y, Moscona R, Ofiram E, Tamir A, Har-Shai Y, et al. Aesthetic results and patient satisfaction with immediate breast reconstruction using tissue expansion: a follow-up study. Plast. Reconstr. Surg. 1997;99:686–691
  53. Schuster RH, Kuske RR, Young VL, Fineberg B. Breast reconstruction in women treated with radiation therapy for breast cancer: cosmesis, complications, and tumor control. Plast. Reconstr. Surg. 1992;90:445–452
  54. Victor SJ, Brown DM, Horwitz EM, Martinez AA, Kini VR, Pettinga JE, et al. Treatment outcome with radiation therapy after breast augmentation or reconstruction in patients with primary breast carcinoma. Cancer. 1998;82:1303–1309
  55. Williams JK, Carlson GW, Bostwick J, Bried JT, Mackay G. The effects of radiation treatment after TRAM flap breast reconstruction. Plast. Reconstr. Surg. 1997;100:1153–1160
  56. Tallet AV, Salem N, Moutardier V, Ananian P, Braud AC, Zalta R, et al. Radiotherapy and immediate two-stage breast reconstruction with a tissue expander and implant: complications and esthetic results. Int. J. Radiat. Oncol. Biol. Phys. 2003;57:136–142
  57. Rosato RM, Dowden RV. Radiation therapy as a cause of capsular contracture. Ann. Plast. Surg. 1994;32:342–345
  58. Canney PA, Dean S. Transforming growth factor beta: a promotor of late connective tissue injury following radiotherapy?. Br. J. Radiol. 1990;63:620–623
  59. Colletta AA, Wakefield LM, Howell FV, van Roozendaal KE, Danielpour D, Ebbs SR, et al. Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. Br. J. Cancer. 1990;62:405–409
  60. Young V. Discussion. Plast. Reconstr. Surg. 2000;106:59–60
  61. Paulhe P, Aubert JP, Magalon G. Forum on tissue expansion. Are tissue expansion and radiotherapy compatible? Apropos of a series of50 consecutive breast reconstructions. Ann. Chir. Plast. Esthet. 1993;38:54–61
  62. Vandeweyer E, Deraemaecker R. Radiation therapy after immediate breast reconstruction with implants. Plast. Reconstr. Surg. 2000;106:56–58
  63. Forman DL, Chiu J, Restifo RJ, Ward BA, Haffty B, Ariyan S. Breast reconstruction in previously irradiated patients using tissue expanders and implants: a potentially unfavorable result. Ann. Plast. Surg. 1998;40:360–363
  64. Kraemer O, Andersen M, Siim E. Breast reconstruction and tissue expansion in irradiated versus not irradiated women after mastectomy. Scand. J. Plast. Reconstr. Surg. Hand Surg. 1996;30:201–206
  65. von Smitten K, Sundell B. The impact of adjuvant radiotherapy and cytotoxic chemotherapy on the outcome of immediate breast reconstruction by tissue expansion after mastectomy for breast cancer. Eur. J. Surg. Oncol. 1992;18:119–123
  66. Halpern J, McNeese MD, Kroll SS, Ellerbroek N. Irradiation of prosthetically augmented breasts: a retrospective study on toxicity and cosmetic results. Int. J. Radiat. Oncol. Biol. Phys. 1990;18:189–191
  67. Ryu J, Yahalom J, Shank B, Chaglassian TA, McCormick B. Radiation therapy after breast augmentation or reconstruction in early or recurrent breast cancer. Cancer. 1990;66:844–847
  68. Evans GR, Schusterman MA, Kroll SS, Miller MJ, Reece GP, Robb GL, et al. Reconstruction and the radiated breast: is there a role for implants?. Plast. Reconstr. Surg. 1995;96:1111–1115
  69. Fodor J, Gulyas G, Polgar C, Major T, Szabo E, Koves I, et al. Radiotherapy and delayed breast reconstruction with implant: examination of compatibility. Magy. Onkol. 2002;46:323–326
  70. Barreau-Pouhaer L, Le MG, Rietjens M, Arriagada R, Contesso G, Martins R, et al. Risk factors for failure of immediate breast reconstruction with prosthesis after total mastectomy for breast cancer. Cancer. 1992;70:1145–1151
  71. Bayet B, Mathieu G, Lavand’Homme P, Vanwijck R. Primary and secondary breast reconstruction with a permanent expander. Eur. J. Plast. Surg. 1991;14:73–79
  72. Fodor J, Gulyas G, Polgar C, Major T, Kasler M. Radiotherapy and breast reconstruction: the issue of compatibility. Orv. Hetil. 2003;144:549–555
  73. Fodor PB, Swistel AJ. Chest wall deformity following expansion of irradiated soft tissue for breast reconstruction. NY State J. Med. 1989;89:419–420
  74. Disa JJ, Cordeiro PG, Heerdt AH, Petrek JA, Borgen PJ, Hidalgo DA. Skin-sparing mastectomy and immediate autologous tissue reconstruction after whole-breast irradiation. Plast. Reconstr. Surg. 2003;111:118–124
  75. Carlson GW, Bostwick J, Styblo TM, Moore B, Bried JT, Murray DR, et al. Skin-sparing mastectomy. Oncologic and reconstructive considerations. Ann. Surg. 1997;225:570–575
  76. Gabka CJ, Bohmert H. Future prospects for reconstructive surgery in breast cancer. Semin. Surg. Oncol. 1996;12:67–75
  77. Fortin A. Delaying post-operative radiotherapy may increase risk of local recurrence in people with breast cancer. Cancer Treat. Rev. 2003;29:441–443
  78. Dowden RV. Selection criteria for successful immediate breast reconstruction. Plast. Reconstr. Surg. 1991;88:628–634
  79. Hunt KK, Baldwin BJ, Strom EA, Ames FC, McNeese MD, Kroll SS, et al. Feasibility of postmastectomy radiation therapy after TRAM flap breast reconstruction. Ann. Surg. Oncol. 1997;4:377–384
  80. Zimmerman RP, Mark RJ, Kim AI, Walton T, Sayah D, Juillard GF, et al. Radiation tolerance of transverse rectus abdominis myocutaneous-free flaps used in immediate breast reconstruction. Am. J. Clin. Oncol. 1998;21:381–385
  81. Kroll SS, Schusterman MA, Reece GP, Miller MJ, Smith B. Breast reconstruction with myocutaneous flaps in previously irradiated patients. Plast. Reconstr. Surg. 1994;93:460–469
  82. Missana MC, Levy C, Barreau-Pouhaer L, Janin N. Radiotherpay and immediate breast reconstruction with myocutaneous flap in breast cancer of reserved prognosis. Ann. Chir. Plast. Esthet. 2000;45:83–89
  83. Nash AG, Taylor PR. Breast reconstruction after failed conservation. Ann. R. Coll. Surg. Engl. 1985;67:303–305
  84. Jacobsen WM, Meland NB, Woods JE. Autologous breast reconstruction with use of transverse rectus abdominis musculocutaneous flap: Mayo clinic experience with 147 cases. Mayo Clin. Proc. 1994;69:635–640
  85. Bostwick J. Discussion. Plast. Reconstr. Surg. 2000;106:318–320
  86. Kroll SS, Gherardini G, Martin JE, Reece GP, Miller MJ, Evans GR, et al. Fat necrosis in free and pedicled TRAM flaps. Plast. Reconstr. Surg. 1998;102:1502–1507
  87. Carlson G. Discussion. Plast. Reconstr. Surg. 2002;109:1925–1926
  88. NIH consensus conference. Treatment of early-stage breast cancer. JAMA 1991;265:391–5
  89. Guenther JM, Tokita KM, Giuliano AE. Breast-conserving surgery and radiation after augmentation mammoplasty. Cancer. 1994;73:2613–2618
  90. Silverstein MJ, Handel N, Gamagami P. The effect of silicone-gel-filled implants on mammography. Cancer. 1991;68:1159–1163
  91. Mark RJ, Zimmerman RP, Greif JM. Capsular contracture after lumpectomy and radiation therapy in patients who have undergone uncomplicated bilateral augmentation mammoplasty. Radiology. 1996;200:621–625
  92. Jacobson GM, Sause WT, Thomson JW, Plenk HP. Breast irradiation following silicone gel implants. Int. J. Radiat. Oncol. Biol. Phys. 1986;12:835–838
  93. Krishnan L, Krishnan EC, Wolf CD, Jewell WR. Preservation of augmented breasts in patients with breast cancer. Radiographics. 1993;13:831–839
  94. Handel N, Lewinsky B, Jensen JA, Silverstein MJ. Breast conservation therapy after augmentation mammaplasty: is it appropriate. Plast. Reconstr. Surg. 1996;98:1216–1224

PII: S0305-7372(04)00119-7

doi: 10.1016/j.ctrv.2004.06.008

Cancer Treatment Reviews
Volume 30, Issue 8 , Pages 671-682 , December 2004

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