Cancer Treatment Reviews
Volume 30, Issue 6 , Pages 545-554, October 2004

Peroxisome proliferator-activated receptor-γ ligands as cell-cycle modulators

  • Stamos Theocharis

      Affiliations

    • Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75, Mikras Asias Street, GR 11527 Athens, Greece
    • Unit of Cytology and Cytometry, Department of Tumor Biology, Medical Section, Institut Curie, 26, rue d'Ulm, 75231 Paris Cedex 05, France
    • Corresponding Author InformationCorresponding author. Present address: 21 Thessalias Street, Zografou, Athens 15772, Greece. Tel./fax: +30-210-778-0114
    • ,
  • Alexandra Margeli

      Affiliations

    • Department of Clinical Biochemistry, “Aghia Sophia” Children's Hospital, Thivon and Papadiamandopoulou Street, GR 11527 Athens, Greece
    • ,
  • Philippe Vielh

      Affiliations

    • Unit of Cytology and Cytometry, Department of Tumor Biology, Medical Section, Institut Curie, 26, rue d'Ulm, 75231 Paris Cedex 05, France
    • ,
  • Gregory Kouraklis

      Affiliations

    • Department of Surgery, Medical School, “Laikon” Hospital, University of Athens, 17, Aghiou Thoma Street, GR 11527 Athens, Greece

Abstract 

The peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for compounds which induce peroxisomal proliferation. PPAR-γ, the best characterized of the PPARs, is a ligand-activated transcription factor and a key regulator of adipogenic differentiation and glucose homeostasis. PPAR-γ ligands have recently been demonstrated to affect proliferation, differentiation and apoptosis of different cell types. Recent in vitro and in vivo studies suggest the importance of specific PPAR-γ ligands as cell-cycle modulators, establishing their antineoplastic properties. In this review, the latest knowledge on the role of PPAR-γ ligands as cell-cycle modulators is presented, discussing also their role in cell proliferation, apoptosis and cancer.

Keywords:  PPAR-γ ligands, Cell cycle, Apoptosis, Cancer, Treatment

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PII: S0305-7372(04)00079-9

doi:10.1016/j.ctrv.2004.04.004

Cancer Treatment Reviews
Volume 30, Issue 6 , Pages 545-554, October 2004

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