Cancer Treatment Reviews
Volume 30, Issue 5 , Pages 405-414 , August 2004

Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review

  • R.P Symonds

      Affiliations

    • University Department of Oncology, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-116-258-6294; fax: +44-116-258-7599
    • ,
  • M Collingwood

      Affiliations

    • Cochrane Gynaecological Cancer CRG, Institute of Health Sciences, PO Box 777, Headington, Oxford OX3 7LF, UK
    • ,
  • J Kirwan

      Affiliations

    • Liverpool Women’s Hospital, Crown Street, Liverpool L8 7SS, UK
    • ,
  • C.E Humber

      Affiliations

    • Department of Oncology, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    • ,
  • J.F Tierney

      Affiliations

    • Meta-analysis Group, MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    • ,
  • J.A Green

      Affiliations

    • Clatterbridge Centre for Oncology, Clatterbridge Hospital, Merseyside CH63 4JY, UK
    • ,
  • C Williams

      Affiliations

    • Cochrane Gynaecological Cancer CRC, Institute of Health Sciences, PO Box 777, Headington, Oxford OX3 7LF, UK

References 

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  2. Sinclair WK. The combined effect of hydroxyurea and X-rays on Chinese hamster cells in vitro. Cancer Res. 1968;28(2):198–206
  3. Phillips RA, Tolmach LJ. Repair of potentially lethal damage in X-irradiated HeLa cells. Radiat. Res. 1966;29(3):413–432
  4. Piver MS, Howes AE, Suit HD, Marshall N. The effect of hydroxyurea on the radiation response to C3H mouse mammary tumours. Cancer. 1972;29:407–412
  5. Piver MS, Barlow JJ, Vongtama V, Webster J. Hydroxyurea and radiation therapy in advanced cervical cancer. Am. J. Obst. Gynecol. 1974;120(7):969–972
  6. Piver MS, Barlow JJ, Vongtama V, Blumenson L. Hydroxyurea as a radiation sensitizer in women with carcinoma of the uterine cervix. Am. J. Obstet. Gynecol. 1977;129:379–383
  7. Piver MS, Barlow J, Vongtama V, Blumenson L. Hydroxyurea: a radiation potentiator in carcinoma of the uterine cervix. Am. J. Obstet. Gynecol. 1983;147:803–808
  8. Piver MS, Vongtama V, Emrich LJ. Hydroxyurea plus pelvic radiation versus placebo plus pelvic radiation in surgically staged stage IIIB cervical cancer. J. Surg. Oncol. 1987;35:129–134
  9. Piver M, Khalil M, Emrich LJ. Hydroxyurea plus pelvic irradiation versus placebo plus pelvic irradiation in nonsurgically stages stage IIIB cervical cancer. J. Surg. Oncol. 1989;42(October):120–125
  10. Hreshchyshyn MM, Aron BS, Boronow RC, Franklin EW, Shingleton HM, Blessing JA. Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. Int. J. Radiat. Oncol. Biol. Phys. 1979;5:317–322
  11. Thigpen JT, Vance R, Puneky L, Khansur T. Chemotherapy as a palliative treatment in carcinoma of the uterine cervix. Seminars Oncol. 1995;22:16–24
  12. Keys HM, Bundy BN, Stehman FB, et al.  Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N. Engl. J. Med. 1999;340:1154–1161
  13. Morris M, Eifel PJ, Lu J, et al.  Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N. Engl. J. Med. 1999;340:1137–1143
  14. Rose PG, Bundy BN, Watkins EB, et al.  Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N. Engl. J. Med. 1999;340:1144–1153
  15. Whitney CW, Sause W, et al.  Randomised comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB–IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J. Clin. Oncol. 1999;17:1339–1348
  16. Peters WA, Liu PY, Barrett RJ, et al.  Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J. Clin. Oncol. 2000;18:1606–1613
  17. Stehman FB, Bundy BN, Keys HM, Currie JL, Mortel R, Cresman WT. A randomised trial of hydroxyurea versus misonidazole adjunct to radiation therapy in carcinoma of cervix: a preliminary report of a Gynaecologic Oncology Group study. Am. J. Obstet. Gynecol. 1988;159:87–94
  18. Stehman FB, Bundy BN, et al.  Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group Trial. J. Clin. Oncol. 1993;11:1523–1528
  19. Stehman FB, Bundy BN. Carcinoma of the cervix treated with chemotherapy and radiation therapy. Cancer Suppl. 1993;71:1697–1701
  20. Madoc JH, Perez C, Camel M, Jennings F. Preliminary experience in a prospective randomized trial to assess the value of hydroxyurea in addition to conventional radiotherapy in the management of advanced stages of carcinoma of the uterine cervix. Int. J. Radiat. Oncol. Biol. Phys. 1980;6:1430
  21. Green JA, Kirwan JM, Tierney JF, Symonds RP, Fresco L, et al.  Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix:a systematic review and meta-analysis. Lancet. 2001;358:781–786
  22. Altman DG. Randomisation. BMJ. 1991;302:1481–1482
  23. Lachin JM. Statistical considerations in the intent-to-treat principle. Control. Clin. Trials. 2000;21:167–189
  24. Schulz KF, Grimes DA. Sample size slippages in randomised trials: exclusions and the lost and the lost and the wayward. Lancet. 2002;359:781–785
  25. Beitler JJ, Anderson P, Haynes H, Sood B, Fields A, Goldberg G, et al.  Phase I clinical trial of parenteral hydroxyurea in combination with pelvic and para-aortic external radiation and brachytherapy for patients with advanced squamous cell cancer of the uterine cervix. Int. J. Radiat. Oncol. Biol. Phys. 2002;52:637–642

PII: S0305-7372(04)00002-7

doi: 10.1016/j.ctrv.2003.12.002

Cancer Treatment Reviews
Volume 30, Issue 5 , Pages 405-414 , August 2004

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