« Previous
Next »
Cancer Treatment Reviews
Volume 29
, Pages 3-9
, May 2003
The proteasome: structure, function, and role in the cell
References
- . Proteasome inhibitors: from research tools to drug candidates. Chem. Biol. 2001;8(8):739–758
-
Abnormally high expression of proteasomes in human leukemic cells.
Proc. Natl. Acad. Sci. USA. 1990;87(18):7071–7075
- Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res. 2002;62(17):4996–5000
- The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001;61(7):3071–3076
- . Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin. Cancer Res. 2000;6(9):3719–3728
- 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer. J. Cell Biochem. 2001;82(1):110–122
- Novel proteasome inhibitor PS-341 inhibits activation of Nuclear Factor-KappaB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin. Cancer Res. 2001;7(5):1419–1428
- Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999;59(11):2615–2622
- . P53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells. Cell Death Differ. 2001;8(3):210–218
- . Tumor growth inhibition induced in a murine model of human Burkitt’s lymphoma by a proteasome inhibitor. Cancer Res. 1998;58(19):4342–4348
- Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. Br. J. Haematol. 1999;105(3):752–757
- The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis. Br. J. Cancer. 1998;77(7):1103–1107
- . Ubiquitin-dependent signaling: the role of ubiquitination in the response of cells to their environment. J. Nutr. 1999;129(11):1933–1936
- . Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 2001;70:503–533
- . The proteasome: a macromolecular assembly designed for controlled proteolysis. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 1999;354(1389):1501–1511
- . Crystal structure of the 20 S Proteasome: TMC-95A complex: a non-covalent proteasome inhibitor. J. Mol. Biol. 2001;311(3):543–548
-
Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of Enolase 1.
Proc. Natl. Acad. Sci. USA. 1998;95(21):12504–12509
- Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg. Med. Chem. Lett. 1998;8(4):333–338
- . Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin rbeta-lactone. J. Biol. Chem. 1996;271(13):7273–7276
-
.
Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli Homolog HslV by a new class of inhibitors.
Proc. Natl. Acad. Sci. USA. 1997;94(13):6629–6634
-
.
Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo anti-inflammatory activity.
Proc. Natl. Acad. Sci. USA. 1999;96(18):10403–10408
- . Eponemycin exerts its antitumor effect through the inhibition of proteasome function. Cancer Res. 1999;59(12):2798–2801
- . Protease inhibitor-induced apoptosis: accumulation of Wt P53, P21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia. 2000;14(7):1276–1283
- . Inhibition of Nuclear Factor KappaB activation attenuates apoptosis resistance in lymphoid cells. Blood. 1998;91(12):4624–4631
- . The proteasome controls the expression of a proliferation-associated nuclear antigen Ki-67. J. Cell Biochem. 2000;76(4):596–604
- Increased proteasome degradation of cyclin-dependent kinase inhibitor P27 is associated with a decreased overall survival in mantle cell lymphoma. Blood. 2000;95(2):619–626
- P27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am. J. Pathol. 1999;154(2):313–323
- . The Rel/NF-KappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol. Cell Biol. 2000;20(8):2687–2695
- . NF-KappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol. Cell Biol. 1999;19(9):5923–5929
- . NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and C-IAP1 and C-IAP2 to suppress caspase-8 activation. Science. 1998;281(5383):1680–1683
- . New insights into role of microenvironment in multiple myeloma. Lancet. 2000;355(9200):248–250
- . Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia. 2000;14(3):399–402
- . The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis. Genes Dev. 1999;13(4):382–387
- Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκB α super-repressor and parthenolide. Oncogene. 2000;19(36):4159–4169
- . Increased and correlated Nuclear Factor-KappaB and Ku autoantigen activities are associated with development of multidrug resistance. Oncogene. 2001;20(42):6048–6056
- Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic Nuclear FactorKappaB inhibition. Cancer Res. 2001;61(9):3535–3540
- Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-κB. Int. J. Radiat. Oncol. Biol. Phys. 2001;50(1):183–193
- . Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. J. Surg. Res. 2001;100(1):11–17
- . Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells. Int. J. Cancer. 2001;96(6):327–333
- Inhibition of proteasome function induced apoptosis in gastric cancer. Int. J. Cancer. 2001;93(4):481–488
-
.
Proteasome inhibitor PS-341 inhibits human multiple myeloma cell growth in a murine model.
Blood. 2001;98(11):774a
- . Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of P21WAF1/Cip1 in human immature leukemic cells. Eur. J. Haematol. 2000;65(4):221–236
-
Generation of PS-341-adapted human multiple myeloma cells as experimental tools for analysis of proteasome function in cancer.
Blood. 2001;98(11):310a
-
Neumeier H, Hoar, K, Pink M, et al. Hypoxia increases potency of the proteasome inhibitor VELCADE (TM) (bortezomib) for injection: potential for a hypoxic cell cytotoxin in solid tumors. Presented at the EORTC-NCI-AACR Conference on Molecular Targets and Cancer Therapeutics; November 19–22, 2002; Frankfurt, Germany
- The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI. Br. J. Haematol. 2001;113(1):126–135
- . Ubiquitin–proteasome system and increased sensitivity of B-CLL lymphocytes to apoptotic death activation. Leuk. Lymphoma. 2000;38(5-6):499–504
- P27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells. Clin. Cancer Res. 2000;6(3):916–923
PII: S0305-7372(03)00081-1
doi: 10.1016/S0305-7372(03)00081-1
© 2003 Elsevier Science Ltd. All rights reserved.
« Previous
Next »
Cancer Treatment Reviews
Volume 29
, Pages 3-9
, May 2003
