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Cancer Treatment Reviews
Volume 29
, Pages 21-31
, May 2003
Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib
References
- Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999;59(11):2615–2622
- . The proteasome inhibitor PS-341 in cancer therapy. Clin. Cancer Res. 1999;5(9):2638–2645
- The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001;61(7):3071–3076
-
Proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma cells to chemotherapeutic agents and overcomes chemoresistance through inhibition of the NF-κB pathway.
Blood. 2001;98(11):437a
-
Generation of PS-341-adapted human multiple myeloma cells as experimental tools for analysis of proteasome function in cancer.
Blood. 2001;98(11):310a
-
Proteasome inhibitor PS-341 inhibits constitutive NF-κB activation and bypasses the anti-apoptotic bcl-2 signal in human multiple myeloma cells.
Blood. 2001;98(11):640a
- . Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. J. Surg. Res. 2001;100(1):11–17
- 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer. J. Cell Biochem. 2001;82(1):110–122
- Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-κB inhibition. Cancer Res. 2001;61(9):3535–3540
- . Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin. Cancer Res. 2000;6(9):3719–3728
-
Neumeier H, Hoar, K, Pink, M, et al. Hypoxia increases potency of the proteasome inhibitor VELCADE (TM) (bortezomib) for injection: potential for a hypoxic cell cytotoxin in solid tumors. Presented at the EORTC-NCI-AACR Conference on Molecular Targets and Cancer Therapeutics; Frankfurt, Germany, November 19–22, 2002
- . Molecular pathways that modify tumor radiation response. Am. J. Clin. Oncol. 2001;24(5):481–485
- Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-κB. Int. J. Radiat. Oncol. Biol. Phys. 2001;50(1):183–193
- . Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J. Clin. Invest. 2001;107(3):241–246
- . Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP. Genes Dev. 1999;13(3):284–294
-
.
Stimulation-dependent IκBα phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin–proteasome pathway.
Proc. Natl. Acad. Sci. USA. 1995;92(23):10599–10603
- . Multiple myeloma: increasing evidence for a multistep transformation process. Blood. 1998;91(1):3–21
- Analysis of expression of nuclear factor kappa B (NF-κB) in multiple myeloma: downregulation of NF-κB induces apoptosis. Br. J. Haematol. 2001;115(2):279–286
- . NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998;281(5383):1680–1683
- . The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-x (L). Mol. Cell. Biol. 2000;20(8):2687–2695
- IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade. J. Immunol. 1997;159(5):2212–2221
- Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. Oncogene. 1997;15(7):837–843
-
Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis.
Proc. Natl. Acad. Sci. USA. 1998;95(26):15671–15676
- . Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ. 1998;5(12):1062–1075
- . Ubiquitin–proteasome system and increased sensitivity of B-CLL lymphocytes to apoptotic death activation. Leuk. Lymphoma. 2000;38(5-6):499–504
- The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-α-initiated apoptosis. Br. J. Cancer. 1998;77(7):1103–1107
-
.
Proteasome inhibitor PS-341 inhibits human multiple myeloma cell growth in a murine model.
Blood. 2001;98(11):774a
- . Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 1997;17(7):3629–3639
- Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J. Clin. Invest. 1997;100(12):2952–2960
- . Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999;18(51):7389–7394
- Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide. Oncogene. 2000;19(36):4159–4169
- . The NF-κB transcription factor and cancer: high expression of NF-κB- and IκB-related proteins in tumor cell lines. Biochem. Pharmacol. 1994;47(1):145–149
- Inhibition of NF-κB-Rel A expression by antisense oligodeoxynucleotides suppresses synthesis of urokinase-type plasminogen activator (uPA) but not its inhibitor PAI-1. Nucleic Acids Res. 1995;23(19):3887–3893
- . Luteinizing hormone-releasing hormone induces nuclear factor κB-activation and inhibits apoptosis in ovarian cancer cells. J. Clin. Endocrinol. Metab. 2000;85(10):3815–3820
- Nuclear factor-κB is upregulated in colorectal cancer. Surgery. 2001;130(2):363–369
- . The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer Res. 1999;5(1):119–127
- Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene. 2001;20(7):859–868
- Autocrine production of interleukin 1β confers constitutive nuclear factor κB activity and chemoresistance in pancreatic carcinoma cell lines. Cancer Res. 2002;62(3):910–916
- . Altered expression of the p50 subunit of the NF-κB transcription factor complex in non-small cell lung carcinoma. Oncogene. 1995;11(5):999–1003
- Expression of a dominant-negative mutant inhibitor-κBα of nuclear factor-κB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. Cancer Res. 1999;59(14):3468–3474
- Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-κB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin. Cancer Res. 2001;7(5):1419–1428
- . In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res. 1996;56(11):2649–2654
- . Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage. Biochem. Biophys. Res. Commun. 1999;262(3):823–827
- . Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21. Oncogene. 1998;17(19):2437–2444
- Role of the ubiquitin–proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995;269(5224):682–685
- . Differential directing of c-Fos and c-Jun proteins to the proteasome in serum-stimulated mouse embryo fibroblasts. Oncogene. 1998;17(3):327–337
- . Turnover of cyclin E by the ubiquitin–proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 1996;10(16):1979–1990
- . Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin–proteasome pathway. Genes Dev. 1997;11(8):957–972
- The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell. 1995;6(2):185–197
- . SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. Cell. 2000;101(7):753–762
- . Drug resistance in colon cancer. Semin. Oncol. 1999;26(6):606–611
-
.
p53-Dependent cell cycle arrest induced by N-acetyl-l-leucinyl-l-leucinyl-l-norleucinal in platelet-derived growth factor-stimulated human fibroblasts.
Proc. Natl. Acad. Sci. USA. 1996;93(20):10815–10819
- . The MYC protein activates transcription of the α-prothymosin gene. EMBO J. 1991;10(1):133–141
- . Proto-oncogene amplification and homogeneously staining regions in human breast carcinomas. Genes. Chromosomes Cancer. 1990;2(1):18–26
- . myc Function and regulation. Annu. Rev. Biochem. 1992;61:809–860
- . Tumor growth inhibition induced in a murine model of human Burkitt’s lymphoma by a proteasome inhibitor. Cancer Res. 1998;58(19):4342–4348
- . Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann. Surg. Oncol. 1999;6(3):279–285
- . Chemotherapy of lung cancer. N. Engl. J. Med. 1992;327(20):1434–1441
- . Gene amplification in human lung cancer. The myc family genes and other proto-oncogenes and growth factor genes. Am. Rev. Respir. Dis. 1990;142(6 Pt 2):S20–S26
- . Nuclear factor-κB/IκB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res. 2000;60(16):4426–4432
- . Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat. Med. 1999;5(4):412–417
- . Roles of NF-κB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human nonsmall cell lung carcinoma. J. Biol. Chem. 2001;276(11):8029–8036
-
.
NF-kB and chemoresistance: potentiation of cancer chemotherapy via inhibition of NF-kB.
Drug Resist. Update. 1999;2:271–273
- . Activation of NF-κB by antineoplastic agents. Role of protein kinase C. J. Biol. Chem. 1997;272(23):14914–14920
- . Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-κB activation. Cancer Res. 2000;60(9):2323–2330
- NF-κB as a therapeutic target in multiple myeloma. J. Biol. Chem. 2002;277(19):16639–16647
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
Proc. Natl. Acad. Sci. USA. 2002;99(22):14374–14379
-
.
Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression.
Proc. Natl. Acad. Sci. USA. 2000;97(8):3850–3855
- The function of multiple IκB:NF-κB complexes in the resistance of cancer cells to taxol-induced apoptosis. Oncogene. 2002;21(42):6510–6519
- . Inhibition of nuclear factor κB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation. J. Thorac. Cardiovasc. Surg. 2002;123(2):310–317
- . Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Cancer Res. 2001;61(15):5926–5932
- . Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs. Cancer Res. 2000;60(9):2429–2434
- . Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response. Biochemistry. 1997;36(47):14418–14429
- Prevention of cisplatin–DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors. Biochem. Pharmacol. 2000;60(9):1343–1354
- . Proteasome inhibition suppresses cisplatin-dependent ERCC-1 mRNA expression in human ovarian tumor cells. Res. Commun. Mol. Pathol. Pharmacol. 2000;107(5-6):387–396
- . Proteasome inhibition: a new strategy in cancer treatment. Invest. New Drugs. 2000;18(2):109–121
- . The proteasome controls the expression of a proliferation-associated nuclear antigen Ki-67. J. Cell Biochem. 2000;76(4):596–604
- . Dual mode of degradation of Cdc25 A phosphatase. EMBO J. 2002;21(18):4875–4884
-
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway.
Proc. Natl. Acad. Sci. USA. 2002;99(4):1990–1995
- . Deadly encounter: ubiquitin meets apoptosis. Nat. Rev. Mol. Cell. Biol. 2002;3(2):112–121
- . The role of the ubiquitin–proteasome pathway in apoptosis. Cell Death Differ. 1999;6(4):303–313
- . NF-κB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer. 2002;2(4):301–310
PII: S0305-7372(03)00079-3
doi: 10.1016/S0305-7372(03)00079-3
© 2003 Elsevier Science Ltd. All rights reserved.
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Cancer Treatment Reviews
Volume 29
, Pages 21-31
, May 2003
