Cancer Treatment Reviews
Volume 29, Issue 5 , Pages 401-406 , October 2003

Treatment of stage IB2 (bulky) cervical carcinoma

  • David H Moore

      Affiliations

    • Corresponding Author InformationCorrespondence to: David H. Moore, MD, Professor and Chief of Gynecologic Oncology, Indiana University School of Medicine, 535 Barnhill Drive, RT 433, Indianapolis, IN 46202-5274, India. Tel.: +317-274-2422; fax: +317-274-4878

References 

  1. Morley GW, Seski JC. Radical pelvic surgery versus radiation therapy for stage I carcinoma of the cervix (exclusive of microinvasion). Am. J. Obstet. Gynecol. 1976;126:785–798
  2. Volterrani F, Feltre L, Sigurta D, et al.  Radiotherapy versus surgery in the treatment of cervix stage Ib cancer. Int. J. Radiat. Oncol. Biol. Phys. 1983;9:1781–1784
  3. Roddick JW, Greenelaw RH. Treatment of cervical cancer: a randomized study of operation and radiation. Am. J. Obstet. Gynecol. 1971;109:754–764
  4. Landoni F, Maneo A, Colombo A, et al.  Randomised study of radical surgery versus radiotherapy for stage Ib–IIa cervical cancer. Lancet. 1997;350:535–540
  5. Feeney DD, Moore DH, Look KY, et al.  The fate of the ovaries after radical hysterectomy and ovarian transposition. Gynecol. Oncol. 1995;56:3–7
  6. Durrance FY, Fletcher GH, Rutledge FN. Analysis of central recurrent disease in stages I and II squamous cell carcinomas of the cervix on intact uterus. Am. J. Roentgenol. 1969;106:831–838
  7. Gallion HH, Van Nagell JR, Donaldson ES, et al.  Combined radiation therapy and extrafascial hysterectomy in the treatment of stage IB barrel-shaped cervical cancer. Cancer. 1985;56:262–265
  8. Mendenhall WM, McCarty PJ, Morgan LS, et al.  Stage IB–IIA–B carcinoma of the intact uterine cervix greater than or equal to 6cm in diameter: is adjuvant extrafascial hysterectomy beneficial. Int. J. Radiat. Oncol. Biol. Phys. 1991;21:899–904
  9. Eifel PJ, Morris M, Wharton JT, Oswald MJ. The influence of tumour size and morphology on the outcome of patients with FIGO stage IB squamous cell carcinoma of the uterine cervix. Int. J. Radiat. Oncol. Biol. Phys. 1994;29:9–16
  10. Fu KK. Biological basis for the interaction of chemotherapeutic agents and radiation therapy. Cancer. 1985;55:2123–2130
  11. Piver MS, Barlow JJ, Vongtama V, Blumenson L. Hydroxyurea: a radiation potentiator in carcinoma of the uterine cervix. Am. J. Obstet. Gynecol. 1983;147:803–808
  12. Hreshchyshyn MM, Aron BS, Boronow RC, et al.  Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. Int. J. Radiat. Oncol. Biol. Phys. 1979;5:317–322
  13. Stehman FB, Bundy BN, Keys H, et al.  A randomized trial of hydroxyurea versus misonidazole adjunct to radiation therapy in carcinoma of the cervix: a preliminary report of a Gynecologic Oncology Group study. Am. J. Obstet. Gynecol. 1988;159:87–94
  14. Stehman FB, Bundy BN, Thomas G, et al.  Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group trial. J. Clin. Oncol. 1993;11:1523–1528
  15. Whitney CW, Sause W, Bundy BN, et al.  A randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stages IIB–IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J. Clin. Oncol. 1999;17:1339–1348
  16. Morris M, Eifel PJ, Lu J, et al.  Pelvic radiation with concurrent chemotherapy versus pelvic and para-aortic radiation for high-risk cervical cancer: a randomized radiation therapy oncology group clinical trial. N. Engl. J. Med. 1999;340:1137–1143
  17. Rose PG, Bundy BN, Watkins EB, et al.  Concurrent cisplatin based radiotherapy and chemotherapy for locally-advanced cervical cancer. N. Engl. J. Med. 1999;340:1144–1153
  18. Peters WA, Liu PY, Barrett RJ, et al.  Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J. Clin. Oncol. 2000;18:1606–1613
  19. Keys HM, Bundy BN, Stehman FB, et al.  Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N. Engl. J. Med. 1999;340:1154–1161
  20. Friedlander ML, Atkinson K, Coppleson JVM, et al.  The integration of chemotherapy into the management of locally advanced cervical cancer: a pilot study. Gynecol. Oncol. 1984;19:1–7
  21. Panici PB, Scambia G, Greggi S, et al.  Neoadjuvant chemotherapy and radical surgery in locally advanced cervical carcinoma: a pilot study. Obstet. Gynecol. 1988;74:344–348
  22. Sardi J, Sananas C, Giaroli A, et al.  Neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri. Gynecol. Oncol. 1990;38:486–493
  23. Dottino PR, Plaxe SC, Beddoe AM, et al.  Induction chemotherapy followed by radical surgery in cervical cancer. Gynecol. Oncol. 1991;40:7–11
  24. Chang HC, Lai CH, Chou PC, et al.  Neoadjuvant chemotherapy with cisplatin, vincristine, and bleomycin and radical surgery in early-stage bulky cervican carcinoma. Cancer Chemother. Pharmacol. 1992;30:281–285
  25. Zanetta G, Landoni F, Colombo A, et al.  Three-year results after neoadjuvant chemotherapy, radical surgery, and radiotherapy in locally-advanced cervical carcinoma. Obstet. Gynecol. 1993;82:447–450
  26. Sardi JE, Sananes CE, Giaroli AA, et al.  Neoadjuvant chemotherapy in cervical carcinoma stage IIB: a randomized controlled trial. Int. J. Gynecol. Cancer. 1998;8:441–450
  27. Chang TC, Lai CH, Hong JH, et al.  Randomized trial of neoadjuvant cisplatin, vincristine, bleomycin, and radical hysterectomy versus radiation therapy for bulky stage IB and IIA cervical cancer. J. Clin. Oncol. 2000;18:1740–1747
  28. Benedetti-Panici P, Greggi S, Colombo A, et al.  Neoadjuvant chemotherapy and radical survery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. J. Clin. Oncol. 2001;20:179–188

PII: S0305-7372(03)00075-6

doi: 10.1016/S0305-7372(03)00075-6

Cancer Treatment Reviews
Volume 29, Issue 5 , Pages 401-406 , October 2003