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Cancer Treatment Reviews
Volume 29, Issue 3
, Pages 189-198
, June 2003
Pathophysiology of bone metastases from prostate cancer and the role of bisphosphonates in treatment
References
- . Cancer statistics. CA Cancer J. Clin. 2002;52:23–47
- . Bone cell matrix promotes the adhesion of human prostatic carcinoma cells via the α2 β1 integrin. Clin. Exp. Metastasis. 1996;14:19–26
-
.
Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line.
J. Nat. Cancer Inst. 1998;90:118–123
- . Excessive bone resorption in human plasmacytomas: direct induction by tumour cells in vivo. Br. J. Haematol. 1995;90:721–724
- . Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. Eur. J. Haematol. 1992;49(4):192–198
- . Quantitative histology of myeloma-induced bone changes. Br. J. Haematol. 1982;52:601–610
- . Bone-resorbing activity in supernatants from lymphoid cell lines. N Engl J. Med. 1974;290:867–871
- . Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J. Med. 1974;291:1041–1046
- . Production of interleukin-1 by bone marrow myeloma cells. Blood. 1989;74:380–387
- . Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. N Engl J. Med. 1987;317:526–532
- . Human myeloma cells promote the recruitment of osteoblast precursors: mediation by interleukin-6 and soluble interleukin-6 receptor. J. Bone Miner. Res. 2000;15:1935–1943
- . Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989;58:573–581
- . The soluble interleukin-6 receptor. Ann. N Y Acad. Sci. 1995;762:207–220 discussion 220–1
- . Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood. 1993;82:1120–1126
- . Clinical significance of elevated soluble interleukin-6 receptor levels in the sera of patients with plasma cell dyscrasias. Br. J. Haematol. 1995;91:116–120
- . Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma. Br. J. Haematol. 1996;93:398–400
- . Increased and highly stable levels of functional soluble interleukin-6* receptor in sera of patients with monoclonal gammopathy. Eur. J. Immunol. 1993;23:820–824
-
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
Proc. Natl. Acad. Sci. USA. 1993;90:11924–11928
- . Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J. Biol. Chem. 1998;273:1872–1879
- . TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 1997;390:465–471
- . Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue. Cancer Res. 1997;57:4427–4431
- . Prostate carcinoma response to cytotoxic therapy: in vivo resistance. In Vivo. 1997;11:453–461
- . Transforming growth factor-β1: comparative immunohistochemical localization in human primary and metastatic prostate cancer. Lab Invest. 1995;73:628–635
- . Identification of a messenger ribonucleic acid fraction in human prostatic cancer cells coding for a novel osteoblast-stimulating factor. Endocrinology. 1985;117:1615–16120
- . Inhibition of osteoblastic cell differentiation by conditioned medium derived from the human prostatic cancer cell line PC-3 in vitro. J. Cell. Biochem. 1997;67:248–256
- . The role of glucocorticoids and prostaglandin E2 in the recruitment of bone marrow mesenchymal cells to the osteoblastic lineage: positive and negative effects. Calcified Tissue International. 1996;59(3):154–162
-
.
Ca 2+-sensing receptor expression and PTHrP secretion in PC38 human prostate cancer cells.
Am. J. Physiol. – Endocrinol. Metabol. 2001;281(6):E1267–E1274
- . Parathyroid hormone-related protein: a potential autocrine growth regulator in human cancer cell lines. Urology. 1994;43(5):675–679
- . Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-β (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects. J. Biol. Chem. 2001;276(39):36241–36250
- . Interleukin-6: a candidate mediator of human prostate cancer morbidity. Urology. 1995;45:542–549
- . Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Res. 1995;55:4633–4639
- . Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro. Cancer Res. 1997;57:141–146
- . Autocrine effect of androgen on proliferation of an androgen responsive prostatic carcinoma cell line, LNCAP: role of interleukin-6. Endocrinology. 1997;138:5071–5074
- . Effect of interleukins on UGT2B15 and UGT2B17 steroid uridine diphosphate-glucuronosyltransferase expression and activity in the LNCaP cell line. Endocrinology. 1998;139:2375–2381
- . Comparative intraosseal growth of human prostate cancer cell lines LNCaP and PC-3 in the nude mouse. Anticancer Res. 1997;17:4253–4258
- . Bone extracellular matrix induces homeobox proteins independent of androgens: possible mechanism for androgen-independent growth in human prostate cancer cells. Prostate. 1996;29:362–367
- . Bone cancer gain without the pain. Nat. Med. 2000;6:504–505
- . Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis. J. Bone Miner. Res. 1999;14:518–527
- . Nordic Myeloma Study Group. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood. 2001;98:2269–2271
- . Human bone marrow myeloma cells express RANKL. J. Clin. Oncol. 2002;20:353–354
- . RANK (receptor activator of nuclear factor-κB) and RANKL expression in multiple myeloma. Br. J. Haematol. 2002;117:86–92
- . Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood. 2001;98:3534–3540
- . Serum osteoprotegerin levels are increased in patients with advanced prostate cancer. Clin. Cancer Res. 2001;7:2977–2983
- . Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells. Cancer Res. 2002;62:1619–1623
- . Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. Cancer Res. 2001;61:4432–4436
- . Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat. Med. 2000;6:521–528 erratum appears in Nat Med 2000 Jul; 6: 838
- . Steering anti-cancer drugs away from the TRAIL. Nat. Med. 2000;6:502–503
- . Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment. Prostate. 1999;39:246–261
- . The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma. Cancer. 2000;88:2989–2994
- . Osteoporosis after orchiectomy for prostate cancer. J. Urol. 1997;157:439–444
- . Skeletal complications of malignancy. Cancer. 1997;80(suppl):1588–1594
-
Saad F, Gleason DM, Murray R, et al. Zoledronic acid reduces skeletal complications in patients with hormone-refractory prostate carcinoma metastatic to bone: a randomized, placebo-controlled trial. J Natl Cancer Inst 2002; xxxxx
- Age-related hip fractures in men: clinical spectrum and short-term outcomes. Osteoporos. Int. 1995;5:419–426
- Generalised increase in bone resorption in carcinoma of the prostate. Br. J. Urol. 1985;57:721–723
- . Morphometric evidence for bone resorption and replacement in prostate cancer. Br. J. Urol. 1991;68:74–80
- Incidence of skeletal complications in patients with bone metastatic prostate cancer and hormone refractory disease: predictive role of bone resorption and formation markers evaluated at baseline. J. Urol. 2000;164:1248–1253
- Markers of bone turnover for the management of patients with bone metastases from prostate cancer. Br. J. Cancer. 2000;82:858–864
- Dichloromethylene-diphosphonate in patients with prostatic carcinoma metastatic to the skeleton. J. Urol. 1985;134:1152–1154
- . Clodronate therapy of metastatic bone disease in patients with prostatic carcinoma. Recent Results Cancer Res. 1989;116:67–72
- . Bisphosphonates as an adjunct to palliative therapy of bone metastases from prostatic carcinoma. A pilot study on clodronate. Br. J. Urol. 1993;72:792–795
- Pain relief and quality-of-life assessment following intravenous and oral clodronate in hormone-escaped metastatic prostate cancer. Br. J. Urol. 1995;76:360–365
- . Bisphosphonates in the management of prostate carcinoma metastatic to the skeleton. Cancer. 2000;88(suppl):3047–3053
- Double-blind, randomised, placebo-controlled, dose-finding study of oral ibandronate in patients with metastatic bone disease. Ann. Oncol. 1999;10:311–316
- Effects of the bisphosphonate olpadronate in patients with carcinoma of the prostate metastatic to the skeleton. Bone. 1998;22:403–408
-
.
Ibandronate in the treatment of prostate cancer associated painful osseus metastases.
Prostate Cancer Prostat. Dis. 2002;5:231–235
- The effect of combined intravenous and oral clodronate treatment on bone pain in patients with metastatic prostate cancer. Ann. Chir. Gynaecol. 1994;83:316–319
- Effect of oral clodronate on bone pain. A controlled study in patients with metastatic prostate cancer. Int. Urol. Nephrol. 1992;24:159–166
- Concomitant i.v. and oral clodronate in the relief of bone pain—a double-blind placebo-controlled study in patients with prostate cancer. Br. J. Cancer. 1997;76:939–942
- The analgesic efficacy of clodronate compared with placebo in patients with painful bone metastases from prostatic cancer. Anticancer Res. 1997;17:4717–4721
- . Palliation of painful bone metastases from prostate cancer using sodium etidronate: results of a randomized, prospective, double-blind, placebo-controlled study. J. Urol. 1989;141:85–87
-
Ernst DS, Tannock IF, Venner PM, et al. Randomized placebo controlled trial of mitoxantrone/prednisone and clodronate versus mitoxantrone/prednisone alone in patients with hormone refractory prostate cancer (HRPC) and pain: National Cancer Institute of Canada Clinical Trials Group study [abstract]. Proc Am Soc Clin Oncol 2002; 21: abs 705, 177a
-
Dearnaley DP, Sydes MR on behalf of the MRC PR05 collaborators. Preliminary evidence that oral clodronate delays symptomatic progression of bone metastases from prostate cancer: First results of the MRC PR05 trial. Proc Am Soc Clin Oncol 2001; 20: abs 693, 174a
- The new bisphosphonate, Zometa (zoledronic acid), decreases skeletal complications in both osteolytic and osteoblastic lesions: a comparison to pamidronate. Cancer Invest. 2002;20(Suppl 2):45–54
PII: S0305-7372(03)00071-9
doi: 10.1016/S0305-7372(03)00071-9
© 2003 Elsevier Science Ltd. All rights reserved.
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Cancer Treatment Reviews
Volume 29, Issue 3
, Pages 189-198
, June 2003
