Cancer Treatment Reviews
Volume 29, Issue 5 , Pages 389-399 , October 2003

Modern management of locally advanced cervical carcinoma

References 

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer. 2001;94:153–156
  2. Richart RM, Barron BA. A follow-up study of patients with cervical displasia. Am. J. Obstet. Gynecol. 1969;105:371–386
  3. Clarke EA, Anderson TW. Does screenning by “Pap” smears help prevent cervical cancer? A case control study. Lancet. 1979;2:1–3
  4. Casas L, Glavan SC, Ordonez RM, et al.  Asian-American variants of human papillomavirus type 16 have extensive mutations in the E2 gene and are highly amplified in cervical carcinomas. Int. J. Cancer. 1999;83:449–455
  5. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J. Clin. 2001;51:15–36
  6. Annual Report on the Results of Treatment in Gynaecological Cancer. J Epidemiol Statist 1998; 3: 5–34
  7. Brunschwig A, Daniel W. Evaluation of pelvic exenteration for advanced cancer of the cervix. Surg. Gynecol. Obstet. 1956;103:337–341
  8. Green JA, Kirwan JM, Tierney JF, et al.  Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet. 2001;358:781–786
  9. Tierney JF, Stewart LA. Neoadjuvant chemotherapy followed by radiotherapy for locally advanced cervix cancer: a meta-analysis using individual patient data from randomised controlled trials. Proc. ASCO. 2002;21:207a; (Abstr 824)
  10. Stewart LA, Tiernay JF. Neoadjuvant chemotherapy and surgery versus standard radiotherapy for locally advanced cervical cancer: a meta-analysis using individual patient data from randomised controlled trials. Proc. ASCO. 2002;21:207a; (Abstr 825)
  11. Hreshchysyn MM, Aron BS, Boronow RC, et al.  Hydroxiurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. Int. J. Radiat. Oncol. Biol. Phys. 1979;5:317
  12. Rose PG, Bundy BN, Watkins EB, et al.  Concurrent cisplatin-based chemo-radiation improves progression-free survival in advanced cervical cancer: results of a randomized Gynecologic Oncology Group study. New Engl. J. Med. 1999;340:1144–1153
  13. Whitney CW, Sause W, Bundy BN, et al.  A randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stages IIB–IVA carcinoma of the cervix with negative para-aortic lymph nodes. A Gynecologic Oncology Group and Southwest Oncology Group Study. J. Clin. Oncol. 1999;17:1339–1348
  14. Keys HM, Bundy BN, Stehman FB, et al.  A comparison of weekly cisplatin during radiation therapy versus irradiation alone each followed by adjuvant hysterectomy in bulky stage IB cervical carcinoma: a randomized trial of the Gynecology Oncology Group. New Engl. J. Med. 1999;340:1154–1161
  15. Morris M, Eifel PJ, Lu J, et al.  Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. New Engl. J. Med. 1999;340:1137–1143
  16. Peters III WA, Liu PY, Barrett R, et al.  Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J. Clin. Oncol. 2000;18:1606–1613
  17. Wong LC, Ngan HYS, Cheung ANY, et al.  Chemo-radiation and adjuvant chemotherapy in cervical cancer. J. Clin. Oncol. 1999;17:2055–2060
  18. Roberts KB, Urdaneta N, Vera R, et al.  Interim results of a randomized trial of mitomycin C as an adjunt to radical radiotherapy in the treatment of locally advanced squamous-cell carcinoma of the cervix. Int. J. Cancer. 2000;90:206–223
  19. Pearcey R, Brundage M, Drouin P, et al.  Phase III trial comparing radical radiotherapy with and and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J. Clin. Oncol. 2002;20:966–972
  20. Rose PG, Bundy BN. Chemo-radiation for locally advanced cervical cancer: does it help?. J. Clin. Oncol. 2002;20:891–893
  21. Tattersall MNH, Lorvidhaya V, Vootiprux , et al.  A randomized trial of epirubicin and cisplatin chemotherapy followed by pelvic radiation in locally advanced cervical cancer. J. Clin. Oncol. 1995;13:444–451
  22. Souhami L, Gil RA, Allan SE, et al.  A randomized trial of chemotherapy followed by pelvic radiotherapy in stage IIIB carcinoma of the cervix. J. Clin. Oncol. 1991;9:970–977
  23. Kumar L, Kaushal R, Nandy M, et al.  Chemotherapy followed by radiotherapy versus radiotherapy alone in locally advanced cervical cancer: a randomized study. Gynecol. Oncol. 1994;54:307–315
  24. Tattersall MH, Ramirez C, Coppleson M. A randomized trial comparing platinum-based chemotherapy followed by radiotherapy vs radiotherapy alone in patients with locally advanced cervical cancer. Int. J. Gynecol. Oncol. 1992;2:244–251
  25. Chauvergne J, Rohart J, Heron JF, Ayme Y, Berlie J, Fargeot P, et al  Randomized trial of initial chemotherapy in 151 locally advanced carcinoma of the cervix (T2b-N1, T3b, MO). Bull. Cancer. 1990;77:1007–1024
  26. Sundorf K, Trope CG, Hogberg T, et al.  Radiotherpay and neoadjuvant chemotherapy for cervical carcinoma. A randomized multicenter study of sequential cisplatin and 5-fluorouracil and radiotherapy in advanced cervical carcinoma. Stage 3B and 4A. Cancer. 1996;77:2371–2376
  27. Leborgne F, Leborgne JH, Doldan R, et al.  Induction chemotherapy and radiotherapy of advanced cancer of the cervix: a pilot study and phase III randomized trial. Int. J. Radiat. Oncol. Biol. Phys. 1997;37:343–349
  28. Herod J, Burton A, Buxton J, et al.  A randomised, prospective, phase III clinical trial of primary bleomycin, ifosfamide and cisplatin (BIP) chemotherapy followed by radiotherapy versus radiotherapy alone in inoperable cancer of the cervix. Ann. Oncol. 2000;11:1175–1181
  29. Sardi J, Sananes C, Giaroli A, et al.  Neoadjuvant chemotherapy in cervical carcinoma stage IIB: a randomized controlled trial. Int. J. Gynecol. Cancer. 1998;8:441–450
  30. Sardi J, Giaroli A, Sananes C, et al.  Randomized trial with neoadjuvant chemotherapy in stage IIIB squamous carcinoma of the cervix uteri: an unexpected therapeutic management. Int. J. Gynecol. Cancer. 1996;6:85–93
  31. Kigawa J, Minagawa Y, Ihshihara H, et al.  The role of neoadjuvant intraarterial infusion chemotherapy with cisplatin and bleomycin for locally advanced cervical cancer. Am. J. Clin. Oncol. 1996;19:255–259
  32. Benedetti-Panici P, Greggi S, Colombo A, et al.  Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer. Results from the Italian Multicenter Randomized Trial. J. Clin. Oncol. 2002;20:179–188
  33. Chang TC, Lai CH, Hong JH, et al.  Randomized trial of neoadjuvant cisplatin, vincristine, bleomycin, and radical hysterectomy versus radiation therapy for bulky stage IB and IIA cervical cancer. J. Clin. Oncol. 2000;18:1740–1747
  34. Mantz CA, Vokes EE, Kies MS, et al.  Sequential induction chemotherapy and concomitant chemoradiotherapy in the management of locoregionally advanced laryngeal cancer. Ann. Oncol. 2001;12:343–347
  35. Vokes EE. Induction chemotherapy followed by concomitant chemoradiotherapy for non-small cell lung cancer. Oncologist. 2001;6(Suppl. 1):25–27
  36. Dueñas-Gonzalez A, Gonzalez EA, Lopez-Graniel C, et al.  A phase II study of gemcitabine and cisplatin combination as induction chemotherapy for untreated locally advanced cervical carcinoma. Ann. Oncol. 2001;12:541–547
  37. Dueñas-Gonzalez A, Mota A, Lopez-Graniel C, et al.  The advantages of concurrent chemo-radiation after neoadjuvant chemotherapy for locally advanced cervical carcinoma. Arch. Med. Res. 2002;33:201–202
  38. Eddy GL. Neoadjuvant chemotherapy before surgery in cervical cancer. Monogr. NCI. 1996;21:93–96
  39. Zanetta G, Lissoni A, Pellegrino A, et al.  Neoadjuvant chemotherapy with cisplatin, ifosfamide and paclitaxel for locally advanced squamous-cell cervical cancer. Ann. Oncol. 1998;9:977–980
  40. Sugiyama T, Nishida T, Kumagai S, et al.  Combination therapy with irinotecan and cisplatin as neoadjuvant chemotherapy in locally advanced cervical cancer. Br. J. Cancer. 1999;81:95–98
  41. Pignata S, Silvestro G, Ferrari E, et al.  Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. J. Clin. Oncol. 1999;17:756–760
  42. Duenas-Gonzalez A, Lopez-Graniel C, Gonzalez-Enciso A, et al.  Concomitant chemo-radiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma. Results from two consecutive phase II trials. Ann. Oncol. 2002;13:1212–1219
  43. Duenas-Gonzalez A, Lopez-Graniel CM, Mota A, Mohar A. Neoadjuvant chemotherapy followed by surgery in locally advanced cervical carcinoma. J. Clin. Oncol. 2002;20:2908–2909 (Letter)
  44. Minagawa Y, Kigawa J, Irie T, et al.  Radical surgery following neodjuvant chemotherapy for patients with stage IIIB cervical cancer. Ann. Surg. Oncol. 1998;5:539–543
  45. Sugiyama T, Nishida T, Hasuo Y, et al.  Neoadjuvant intraarterial chemotherapy followed by radical hysterectomy and/or radiotherapy for locally advanced cervical cancer. Gynecol. Oncol. 1998;69:130–136
  46. Lopez-Graniel CM, Reyes M, Chanona , et al.  Type III radical histerectomy after induction chemotherapy for patients with locally advanced cervical carcinoma. Int. J. Gynecol. Cancer. 2001;11:210–217
  47. Sardi J, Sananes C, Giaroli A, et al.  Neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri. Gynecol. Oncol. 1990;38:486–493
  48. Kies MS, Haraf DJ, Athanasiadis I, et al.  Induction chemotherapy followed by concurent chemo-radiation for advanced head and neck cancer: improved disease control and survival. J. Clin. Oncol. 1998;16:271–275
  49. Ampil FL, Milis GM, Burton GV. Induction chemotherapy followed by concomitant chemo-radiation for cervical esophageal cancer. Am. J. Gastroenterol. 1999;94:2325–2326
  50. Dueñas-Gonzalez A, Lopez-Graniel C, Gonzalez AE, et al.  Induction chemotherapy with gemcitabine and oxaliplatin for locally advanced cervical carcinoma. Am. J. Clin. Oncol. 2003;26:22–25
  51. Cerrotta A, Gardan G, Cavina R, et al.  Concurrent radiotherapy and weekly paclitaxel for locally advanced or recurrent squamous cell carcinoma of the uterine cervix. A pilot study with intensification of dose. Eur. J. Gynaecol. Oncol. 2002;23:115–119
  52. Dunton CJ, King SA, Neufeld J, et al.  Phase I study of topotecan and radiation therapy in advanced cervical cancer. Gynecol. Oncol. 2002;85:185–187
  53. Lawrence TS, Eisbruch A, Shewach DS. Gemcitabine-mediated radiosensitization. Semin. Oncol. 1997;24:S7-24–S7-28
  54. Hernández P, Olivera P, Dueñas-Gonzalez A, et al.  Gemcitabine activity in cervical cancer cell lines. Cancer Chemother. Pharmacol. 2001;48:488–492
  55. Mose S, Karapetian M, Juling-Pohlit L, et al.  The intensification of the radiotherapeutic effect on HeLa cells by gemcitabine. Strahlenther. Onkol. 1999;175:78–83
  56. Burnett AF, Roman LD, Garcia AA, Muderspach LI, Brader KR, Morrow CP. A phase II study of gemcitabine and cisplatin in patients with advanced, persistent, or recurrent squamous cell carcinoma of the cervix. Gynecol. Oncol. 2000;76:63–66
  57. Dueñas-González A, Lara-Medina F, Hinojosa-Garcı́a LM, et al.  Weekly cisplatin and low-dose gemcitabine combination for advanced and recurrent cervical carcinoma. Am. J. Clin. Oncol. 2001;24:201–203
  58. McCormack M, Thomas H. A phase Ib study of gemcitabine (GEM) and concurrent radiotherapy (RT) in carcinoma of the cervix. Ann. Oncol. 2000;11(Suppl. 4):88–89 (Abstr 396P)
  59. Pattaranutaporn P, Thirapakawong C, Chansilpa Y, Thersakvivhya S, Ieumwananontachai N, Thephamongkhol K. Phase II study of concurrent gemcitabine and radiotherapy in locally advanced stage IIIB cervical carcinoma. Gynecol. Oncol. 2001;81:404–407
  60. Zarba J, Jaremtchuk A, Cedaro M, et al.  A phase I–II study of weekly cisplatin and gemcitabine with concurrent radiotherapy in locally advanced cervical cancer. Proc. ASCO. 2001;20:206a; (abstr 822)
  61. Pisters PW, Ballo MT, Patel SR. Preoperative chemo-radiation treatment strategies for localized sarcoma. Ann. Surg. Oncol. 2002;9:535–542
  62. Theodoropoulos G, Wise WE, Padmanabhan A, et al.  T-level downstaging and complete pathologic response after preoperative chemo-radiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis. Colon. Rectum. 2002;45:895–903
  63. Meluch AA, Hainsworth JD, Gray JR, et al.  Preoperative combined modality therapy with paclitaxel, carboplatin, prolonged infusion 5-fluorouracil, and radiation therapy in localized esophageal cancer: preliminary results of a Minnie Pearl Cancer Research Network phase II trial. Cancer J. Sci. Am. 1999;5:84–91
  64. Vora SA, Daly BD, Blaszkowsky L, et al.  High dose radiation therapy and chemotherapy as induction treatment for stage III nonsmall cell lung carcinoma. Cancer. 2000;89:1946–1952
  65. Resbeut M, Cowen D, Viens P, et al.  Concomitant chemo-radiation prior to surgery in the treatment of advanced cervical carcinoma. Gynecol. Oncol. 1994;54:68–75
  66. Jurado M, Martinez-Monje R, Garcia-Foncillas J, et al.  Pilot study of concurrent cisplatin, 5-fluorouracil, and external beam radiotherapy prior to radical surgery +/− intraoperative electron beam radiotherapy in locally advanced cervical cancer. Gynecol. Oncol. 1999;74:30–37
  67. Mancuso S, Smaniotto D, Benedetti-Panici P, et al.  Phases I–II trial of preoperative chemo-radiation in locally advanced cervical carcinoma. Gynecol. Oncol. 2000;78:324–328

PII: S0305-7372(03)00068-9

doi: 10.1016/S0305-7372(03)00068-9

Cancer Treatment Reviews
Volume 29, Issue 5 , Pages 389-399 , October 2003

Article Tools