Cancer Treatment Reviews
Volume 29, Issue 1 , Pages 69-71 , February 2003

Paclitaxel plus gemcitabine may be as active and well tolerated as paclitaxel plus carboplatin for advanced non-small-cell lung cancer

  • Yuh-Min Chen, md, Phd, fccp Associate Professor, Medical Oncologist and Chest Physician

References 

  1. Non-Small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. BMJ 1995; 311: 899–909
  2. Bunn PA. Chemotherapy for advanced non-small-cell lung cancer: who, what, when, why?. J. Clin. Oncol. 2002;20:23S–33S
  3. Chen YM, Perng RP, Lee YC, et al.  Paclitaxel plus carboplatin, compared with paclitaxel plus gemcitabine, shows similar efficacy while more cost-effective: a randomized phase II study of combination chemotherapy against inoperable non-small-cell lung cancer previously untreated. Ann. Oncol. 2002;13:108–115
  4. Raftopoulos H, Gralla RJ, Bria E, Eid A. Assessing the role of chemotherapy in advanced non-small cell lung cancer (NSCLC): a comprehensive review of large, randomized trials 1991–2001. Proc. Am. Soc. Clin. Oncol. 2002;21:a1284
  5. Georgoulias V, Papadakis E, Alexopoulos A, et al.  Platinum-based and non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a randomised multicentre trial. Lancet. 2001;357:1478–1484
  6. Schiller JH, Harrington D, Belani CP, et al.  Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. New Engl. J. Med. 2002;346:92–98
  7. Giaccone G. Early results of a randomized phase III trial of platinum-containing doublets versus a non-platinum doublet in the treatment of advanced non-small cell lung cancer: European Organization for Research and Treatment of Cancer 08975. Semin. Oncol. 2002;29(Suppl 9):47–49

 Sources of funding: none specified

☆☆ For correspondence: P.A. Kosmidis, Hygeia Hospital, Athens, Greece. E-mail: parkosmi@otenet.gr

 Abstract provided by Bazian Ltd, London

PII: S0305-7372(02)00127-5

doi: 10.1016/S0305-7372(02)00127-5

Cancer Treatment Reviews
Volume 29, Issue 1 , Pages 69-71 , February 2003