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Cancer Treatment Reviews
Volume 28, Issue 4
, Pages 195-214
, August 2002
The metabolic syndrome in long-term cancer survivors, and important target for secondary preventive measures
References
- . Cancer survival rates continue to rise in the Netherlands. BMJ. 2001;322:1509
- . Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. J. Clin. Oncol. 2000;18:1725–1732
- . Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer. Ann. Oncol. 2002;13:229–236
- . Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. J. Clin. Endocrinol. Metab. 1996;81:3051–3055
- . Impaired glucose tolerance and dyslipidaemia as late effects after bone marrow transplantation in childhood. Lancet. 2000;356:993–997
- . High incidence of obesity in young adults after treatment of acute lymphoblastic leukemia in childhood. J. Pediatr. 1995;127:63–67
- . Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. Cancer. 2000;88:2116–2121
- . Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia. J. Pediatr. Hematol. Oncol. 2001;23:424–430
-
National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Circulation 1994; 89: 1333–1445
- . Late deaths and survival after childhood cancer: implications for cure. BMJ. 1994;309:162–166
- . Late mortality of long-term survivors of childhood cancer. J. Clin. Oncol. 1997;15:2205–2213
- . Cancer and cardiac mortality among 15-year survivors of cancer diagnosed during childhood or adolescence. J. Clin. Oncol. 1999;17:3207–3215
- . Death during adulthood in survivors of childhood and adolescent cancer. Cancer. 1994;73:3094–3102
- . Late deaths after treatment for childhood cancer. Arch. Dis. Child. 1990;65:1356–1363
- . Late mortality experience in five-year survivors of childhood and adolescent cancer: the childhood cancer survivor study. J. Clin. Oncol. 2001;19:3163–3172
- . Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries. J. Clin. Oncol. 2001;19:3173–3181
- . Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607
- . Insulin resistance syndrome and atherosclerotic cardiovascular disease. Acta. Clin. Belg. 1996;51:65–69
- . Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173–194
- . Syndrome X: 10 years after. Drugs. 1999;58(Suppl. 1):19–20
- . Syndrome X and mortality: a population-based study. Risk Factor and Life Expectancy Research Group. Am. J. Epidemiol. 1998;148:958–966
- . Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes. 1992;41:715–722
- . Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study. Diabetes. 1997;46:1594–1600
- . General characteristics of the insulin resistance syndrome: prevalence and heritability. European Group for the study of Insulin Resistance (EGIR). Drugs. 1999;58(Suppl. 1):7–10
-
.
Endothelial dysfunction: cause of the insulin resistance syndrome.
Diabetes. 1997;46(Suppl. 2):S9–S13
- . Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet. 2001;358:1400–1404
-
.
The metabolic syndrome—a neuroendocrine disorder.
Br. J. Nutr. 2000;83(1):S49–S57
- . Growth hormone and the metabolic syndrome. J. Endocrinol. Invest. 1999;22:41–46
- . The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int. J. Obes. Relat. Metab. Disord. 2000;24(Suppl. 2):S50–S55
- . The adrenal and the metabolic syndrome. Curr. Hypertens. Rep. 2001;3:117–120
- . Childhood cancer and later development of the metabolic syndrome. Ann. Med. 1997;29:353–355
- . Long-term effects of allogeneic bone marrow transplantation BMT on pituitary, gonad, thyroid and adrenal function in adults. Bone Marrow Transplant. 1998;22:331–337
- . Endocrine late effects of childhood cancers. J. Pediatr. 1997;131:S37–S41
- . Long-term effects of cranial irradiation on endocrine function in children with brain tumors. A prospective study. Cancer. 1985;56:2189–2193
- . Endocrine consequences of treatment of malignant disease. Arch. Dis. Child. 1989;64:1635–1641
- . Growth and growth hormone status following treatment for childhood leukaemia. Horm. Res. 1998;50:1–10
- . Growth hormone response to a growth hormone-releasing hormone stimulation test in a population-based study following cranial irradiation of childhood brain tumors. Horm. Res. 2000;54:53–59
- . Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation. 1988;78:539–545
- . Usefulness of sex steroid hormone levels in predicting coronary artery disease in men. Am. J. Cardiol. 1987;60:771–777
- . Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism. 1990;39:897–901
- . Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism. 1994;43:599–603
- . Effect of obesity and body fat distribution on sex hormones and insulin in men. Metabolism. 1991;40:101–104
- . Interrelation between plasma testosterone and plasma insulin in healthy adult men: the telecom study. Diabetologia. 1992;35:173–177
- . The effects of testosterone on insulin sensitivity in male rats. Acta. Physiol. Scand. 1992;146:505–510
- . Insulin resistance and diminished glucose tolerance in powerlifters ingesting anabolic steroids. J. Clin. Endocrinol. Metab. 1987;64:960–963
- . Testosterone concentrations in women and men with NIDDM. Diabetes Care. 1994;17:405–411
- . Endogenous sex hormone levels in older adult men with diabetes mellitus. Am. J. Epidemiol. 1990;132:895–901
- . Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus. Ann. Intern. Med. 1992;117:807–811
- . Hypogonadism and androgen replacement therapy in elderly men. Am. J. Med. 2001;110:563–572
- . Effects of testosterone replacement in hypogonadal men. J. Clin. Endocrinol. Metab. 2000;85:2670–2677
- . Functional cardiac disturbances related to chemotherapy independent of anthracycline use in children with neoplastic disease. Am. J. Cardiol. 1995;75:101–103
- . Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men—a clinical research center study. J. Clin. Endocrinol. Metab. 1996;81:3469–3475
- . Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. J. Clin. Endocrinol. Metab. 2001;86:3604–3610
- . The administration of pharmacological doses of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance. J. Clin. Endocrinol. Metab. 1989;68:971–975
- . Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J. Clin. Endocrinol. Metab. 1996;81:4358–4365
- . Metabolic and behavioral effects of high-dose, exogenous testosterone in healthy men. J. Clin. Endocrinol. Metab. 1994;79:561–567
- . Plasma testosterone, high density lipoprotein cholesterol and other lipoprotein fractions. Am. J. Cardiol. 1981;48:897–902
- . Suppression of endogenous testosterone in young men increases serum levels of high density lipoprotein subclass lipoprotein A-I and lipoprotein(a). J. Clin. Endocrinol. Metab. 1997;82:3367–3372
-
.
Physiologic testosterone levels in normal men suppress high-density lipoprotein cholesterol levels.
Ann. Int. Med. 1992;116:967–973
- . Changes in lipoprotein-lipid levels in normal men following administration of increasing doses of testosterone cypionate. Clin. J. Sport Med. 1996;6:152–157
-
.
Testosterone enanthate at a dose of 200
mg/week decreases HDL-cholesterol levels in healthy men.
Int. J. Androl. 1995;18:237–242 - . Interrelationships among lipoprotein levels, sex hormones, anthropometric parameters, and age in hypogonadal men treated for 1 year with a permeation-enhanced testosterone transdermal system. J. Clin. Endocrinol. Metab. 2001;86:1026–1033
- . Effects of long-term use of testosterone enanthate. II. Effects on lipids, high and low density lipoprotein cholesterol and liver function parameters. Int. J. Androl. 1999;22:347–355
- . Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men. Atherosclerosis. 1996;121:35–43
- . Hormonal regulation of serum lipoprotein a levels: effects of parenteral administration of oestrogen or testosterone in males. J. Clin. Endocrinol. Metab. 1996;81:2633–2637
- . Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation. 1996;94:2614–2619
- . The therapeutic value of testosterone propionate in angina pectoris. N. Engl. J. Med. 1943;229:770–772
-
.
Testosterone propionate therapy in one hundred cases of angina pectoris.
J. Clin. Endocrinol. 1946;6:549–557
- . Acute anti-ischaemic effect of testosterone in men with coronary artery disease. Circulation. 1999;99:1666–1670
- . Endocrinological late effects after chemotherapy for testicular cancer. Br. J. Cancer. 1996;73:1108–1114
- . The impact of chemotherapy on Leydig cell function in long term survivors of germ cell tumors. Cancer. 2001;91:1297–1303
- . High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood. Cancer. 2001;91:613–621
- . Castration and diabetes. Diabetes Care. 2000;23:1032–1033
- . The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer. J. Clin. Endocrinol. Metab. 2001;86:4261–4267
- . Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy. Clin. Endocrinol. (Oxf). 2001;55:315–324
- . The protective effects of oestrogen on the cardiovascular system. N. Engl. J. Med. 1999;340:1801–1811
-
Effects of Oestrogen or oestrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Oestrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. JAMA 1995; 273: 199–208
- . Oestrogen replacement and brachial artery flow-mediated vasodilation in older women. Arterioscler. Thromb. Vasc. Biol. 2001;21:1955–1961
- . Abnormal vascular function and hypertension in mice deficient in oestrogen receptor β. Science. 2002;295:505–508
- . Association of oestrogen receptor beta (ESR2) gene polymorphism with blood pressure. J. Hum. Genet. 2000;45:327–330
- . Hormone replacement therapy, heart disease, and other considerations. Annu. Rev. Public. Health. 1998;19:55–72
- . Randomized trial of oestrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Oestrogen/progestin Replacement Study (HERS) Research Group. JAMA. 1998;280:605–613
-
.
Risk of recurrent coronary events in relation to use and recent initiation of postmenopausal hormone therapy.
Arch. Int. Med. 2001;161:1709–1713
-
.
A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease.
Ann. Int. Med. 2000;133:933–941
- . Oestrogens and lipids. Can HRT designer oestrogens, and phytoestrogens reduce cardiovascular risk markers after menopause?. Postgrad. Med. 2002;111:23–30
- . Ovarian injury and modern options to preserve fertility in female cancer patients treated with high dose radio-chemotherapy for hemato-oncological neoplasias and other cancers. Leuk Lymphoma. 1999;33:65–76
- . Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer. J. Clin. Oncol. 2001;19:3306–3311
- . Ovarian function after bone marrow transplantation during childhood. Bone Marrow Transplant. 1998;21:287–290
- . Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: response to sex steroid replacement. Br. J. Obstet. Gynaecol. 1999;106:1265–1272
- . Factors affecting gonadal function after bone marrow transplantation during childhood. Bone Marrow Transplant. 2001;28:67–75
- . Effects of chemotherapy-induced castration on serum lipids and apoproteins in premenopausal women with node-positive breast cancer. J. Clin. Endocrinol. Metab. 1996;81:4453–4457
- . On some late effects of bilateral oophorectomy in the age range 15–30 years. Acta Obstet. Gynecol. Scand. 1975;54:449–461
- . Abdominal obesity and the metabolic syndrome. Ann. Med. 1992;24:465–468
- . Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990;336:285–288
- . The effect of hypopituitarism on life expectancy. J. Clin. Endocrinol. Metab. 1996;81:1169–1172
- . Increased cerebrovascular mortality in patients with hypopituitarism. Clin. Endocrinol. (Oxf). 1997;46:75–81
- . Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet. 2001;357:425–431
- . Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy. J. Endocrinol. Invest. 1999;22:28–32
- . Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J. Clin. Endocrinol. Metab. 1998;83:382–395
- . High fibrinogen and plasminogen activator inhibitor activity in growth hormone-deficient adults. Arterioscler. Thromb. 1994;14:434–437
- . Endothelial dysfunction in hypopituitary adults with growth hormone deficiency. Clin. Endocrinol. (Oxf). 1999;50:457–464
- . Effects of GH replacement on endothelial function and large-artery stiffness in GH-deficient adults: a randomized, double-blind, placebo-controlled study. Clin. Endocrinol. (Oxf). 2002;56:493–501
- . Growth hormone corrects vascular dysfunction in patients with chronic heart failure. J. Am. Coll. Cardiol. 2002;39:90–95
-
.
Abnormal vascular reactivity in growth hormone deficiency.
Circulation. 2001;103:520–524
- . Increased arterial intima-media thickness in childhood-onset growth hormone deficiency. J. Clin. Endocrinol. Metab. 1997;82:1378–1381
- . Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. J. Clin. Endocrinol. Metab. 1993;77:1671–1676
- . Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency. J. Clin. Endocrinol. Metab. 1999;84:2373–2380
- . Effects of 7 years of growth hormone replacement therapy in hypopituitary adults. J. Clin. Endocrinol. Metab. 2000;85:3762–3769
- . Growth and growth hormone secretion after treatment for acute lymphoblastic leukemia in childhood. 18-Gy versus 24-Gy cranial irradiation. J. Pediatr. Hematol. Oncol. 1995;17:167–171
- . Reduced growth hormone secretion with maintained periodicity following cranial irradiation in children with acute lymphoblastic leukaemia. Clin. Endocrinol. (Oxf). 1995;42:153–159
- . Toxicities of total-body irradiation for pediatric bone marrow transplantation. Int. J. Radiat. Oncol. Biol. Phys. 1996;34:843–851
- . Late effects of intensive treatment for acute myeloid leukemia and myelodysplasia in childhood. J. Clin. Oncol. 1994;12:916–924
- . Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinol. (Copenh.). 1993;129:195–200
- . Thyroid disease and its treatment: short-term and long-term cardiovascular consequences. Curr. Opin. Pharmacol. 2001;1:626–631
- . Cardiovascular and atherogenic aspects of subclinical hypothyroidism. Thyroid. 2000;10:665–679
- . The treatment of subclinical hypothyroidism is seldom necessary. J. Clin. Endocrinol. Metab. 2001;86:4591–4599
- . The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin. Endocrinol. (Oxf). 1995;43:55–68
-
.
Relationship of subclinical hypothyroidism to cardiovascular risk factors and disease in an elderly population.
Thyroid. 1994;4(Suppl. 1):S18
-
.
Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: The Rotterdam Study.
Ann. Int. Med. 2000;132:270–278
- . Flow-mediated, endothelium-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin (TSH) values. Thyroid. 1997;7:411–414
-
.
L-Thyroxine therapy in subclinical hypothyroidism. A double-blind, placebo-controlled trial.
Ann. Int. Med. 1984;101:18–24
- . A double-blind cross-over 12-month study of L-thyroxine treatment of women with ‘subclinical’ hypothyroidism. Clin. Endocrinol. (Oxf). 1988;29:63–75
- . Abnormalities of the thyroid in survivors of Hodgkin’s disease: data from the Childhood Cancer Survivor Study. J. Clin. Endocrinol. Metab. 2000;85:3227–3232
- . Thyroid dysfunction following radiotherapy for head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 1995;31:279–283
- . Hypothyroidism: a frequent event after radiotherapy and after radiotherapy with chemotherapy for patients with head and neck carcinoma. Cancer. 2001;92:2892–2897
- . Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2001;50:1287–1294
- . Long-term complications of total body irradiation in adults. Int. J. Radiat. Oncol. Biol. Phys. 2001;49:125–131
- . Endocrine function and bone metabolism 5 years after autologous bone marrow/blood-derived progenitor cell transplantation. Cancer. 1997;79:1617–1622
- . Endocrine function following single fraction and fractionated total body irradiation for bone marrow transplantation in childhood. Acta Endocrinol. (Copenh.). 1993;128:508–512
- . Endocrine deficit after fractionated total body irradiation. Arch. Dis. Child. 1992;67:1107–1110
- . Thyroid dysfunction among long-term survivors of bone marrow transplantation. Am. J. Med. 1982;73:688–694
- . Severe hypothyroidism after chemotherapy and locoregional irradiation for breast cancer. Radiother. Oncol. 2000;57:103–105
- . Tamoxifen, serum lipoproteins and cardiovascular risk. Br. J. Cancer. 1988;58:497–499
- . Thyroid function after postoperative radiation therapy in patients with breast cancer. Acta Radiol. Oncol. 1986;25:167–170
- . Magnesium and phosphorus. Lancet. 1998;352:391–396
- . Magnesium in diabetes mellitus. Neth. J. Med. 1999;54:139–146
- . Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study. Ann. Epidemiol. 1999;9:159–165
- . Model of cardiovascular injury in magnesium deficiency. Med. Hypotheses. 2001;56:110–113
- . Seizures in a patient with disseminated testicular cancer due to cisplatin-induced hypomagnesaemia. Acta Oncol. 2000;39:239–240
- . Magnesium and phosphorus. Lancet. 1998;352:1476
-
.
Magnesium metabolism. A review with special reference to the relationship between intracellular content and serum levels.
Arch. Int. Med. 1988;148:2415–2420
- . Effect of variations in plasma magnesium concentration on resistance to insulin-mediated glucose disposal in nondiabetic subjects. J. Clin. Endocrinol. Metab. 1997;82:3783–3785
- . Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension. 1993;21:1024–1029
- . Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study. J. Clin. Epidemiol. 1995;48:927–940
- . Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Metabolism. 2000;49:418–420
- . Oral magnesium supplementation in insulin-requiring Type 2 diabetic patients. Diabet. Med. 1998;15:503–507
- . Effect of magnesium treatment on glycemic control and metabolic parameters in NIDDM patients. Diabetes Care. 1994;17:460–461
- . Hypomagnesemia in type II diabetes: effect of a 3-month replacement therapy. Diabetes Care. 1995;18:188–192
- . Magnesium and trace metals: risk factors for coronary heart disease? Association between blood levels and angiographic findings. Circulation. 1981;64:722–729
- . Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study. Am. J. Clin. Nutr. 1987;45:469–475
- . Dietary calcium, potassium, magnesium and blood pressure in the Netherlands. Int. J. Epidemiol. 1995;24:1117–1123
- . The relationship between dietary intake and urinary excretion of sodium, potassium, calcium and magnesium: Belgian Interuniversity Research on Nutrition and Health. J. Hum. Hypertens. 1990;4:527–533
- . Relation of electrolytes to blood pressure in men. The Yi people study. Hypertension. 1991;17:378–385
- . A prospective study of nutritional factors and hypertension among US women. Circulation. 1989;80:1320–1327
- . A prospective study of nutritional factors and hypertension among US men. Circulation. 1992;86:1475–1484
- . Platinum organ toxicity and possible prevention in patients with testicular cancer. Int. J. Cancer. 1999;83:866–869
-
.
Hypomagnesemia after cisplatin combination chemotherapy.
Arch. Int. Med. 1984;144:2347–2348
- . Radiation injury to the heart. Int. J. Radiat. Oncol. Biol. Phys. 1995;31:1205–1211
- . Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. Pediatr. Nephrol. 1998;12:572–575
- . Acute and chronic effects of cisplatin therapy on renal magnesium homeostasis. Med. Pediatr. Oncol. 1997;28:35–40
- . Partial reversibility of cisplatin nephrotoxicity in children. J. Pediatr. 1991;118:531–534
- . Evaluation of long-term toxicity after chemotherapy for testicular cancer. J. Clin. Oncol. 1996;14:2923–2932
- . Clinical and biochemical long-term toxicity after postoperative cisplatin-based chemotherapy in patients with low-stage testicular cancer. Oncology. 1995;52:300–305
- . Long-term renal function after treatment for malignant germ-cell tumours. Ann. Oncol. 2002;13:222–228
- . Cardiac failure and dysrhythmias 6–19 years after anthracycline therapy: A series of 15 patients. Med. Pediatr. Oncol. 1995;24:352–361
- . Early anthracycline cardiotoxicity. Am. J. Med. 1978;65:823–832
- . Acute vascular ischaemic events after cisplatin-based combination chemotherapy for germ-cell tumors of the testis. Ann. Intern. Med. 1986;105:48–51
- . Severe vascular toxicity associated with cisplatin-based chemotherapy. Cancer. 1993;72:587–593
- . Angina pectoris following cisplatin, etoposide, and bleomycin in a patient with advanced testicular cancer. Ann. Pharmacother. 1995;29:138–139
- . Fatal cerebrovascular accident associated with chemotherapy for testicular cancer. Eur. J. Cancer. 1993;29A:1220–1221
- . Thromboembolic events during chemotherapy for germ cell cancer: a cohort study and review of the literature. J. Clin. Oncol. 2000;18:2169–2178
-
.
Long-term follow-up of cardiovascular risk factors in patients given chemotherapy for disseminated nonseminomatous testicular cancer.
Ann. Int. Med. 1992;116:709–715
- . Severe vascular toxicity associated with vinblastine, bleomycin, and cisplatin chemotherapy. Cancer Chemother. Pharmacol. 1987;19:253–256
- . Cisplatin-based combination chemotherapy for disseminated germ cell tumors: long-term follow-up. J. Clin. Oncol. 1988;6:1239–1247
- . Ten-year survival and late sequelae in testicular cancer patients treated with cisplatin, vinblastine, and bleomycin. J. Clin. Oncol. 1989;7:1099–1104
- . Vascular toxicity associated with antineoplastic agents. J. Clin. Oncol. 1986;4:1405–1417
- . Release of cytokines from human umbilical vein endothelial cells treated with platinum compounds in vitro. Jpn. J. Cancer Res. 1998;89:757–767
- . Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin. Ultrastruct. Pathol. 1997;21:289–299
- . Vitamin E prevents endothelial injury associated with cisplatin injection into the superior mesenteric artery of rats. Heart Vessels. 1995;10:178–184
- . The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Am. J. Pathol. 1974;77:185–197
- . In vitro toxicity studies with mitomycins and bleomycin on endothelial cells. Anticancer Drugs. 1997;8:859–868
- . Bleomycin stimulates production of transforming growth factor-beta by rat pulmonary artery endothelial cells. Chest. 1991;99:66S
- . Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome. Drugs. 2001;61:641–684
- . 2002 Update of Recommendations for the Use of Chemotherapy and Radiotherapy Protectants: Clinical Practice Guidelines of the American Society of Clinical Oncology. J. Clin. Oncol. 2002;20:2895–2903
- . Improved endothelial function with metformin in type 2 diabetes mellitus. J. Am. Coll. Cardiol. 2001;37:1344–1350
- . Simvastatin, capillary permeability, and acetylcholine-mediated vasomotion in atherosclerotic, hypercholesterolemic men. Clin. Pharmacol. Ther. 2000;68:427–434
- . Vascular effects of oestrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women. Circulation. 1999;99:354–360
- . Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men. J. Am. Coll. Cardiol. 1998;32:711–716
- . Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 2001;344:1343–1350
- . Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20:537–544
- . Lifestyle intervention in overweight individuals with a family history of diabetes. Diabetes Care. 1998;21:350–359
- . Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 2002;346:393–403
- . Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30. Metabolism. 2001;50:856–861
-
.
Metformin improves blood lipid pattern in nondiabetic patients with coronary heart disease.
J. Int. Med. 1996;239:227–233
☆ Supported by Grant RUG2000-2177 from the Dutch Cancer Society.
PII: S0305-7372(02)00038-5
© 2002 Elsevier Science Ltd. All rights reserved.
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Cancer Treatment Reviews
Volume 28, Issue 4
, Pages 195-214
, August 2002
