Cancer Treatment Reviews
Volume 27, Issue 4 , Pages 247-255, August 2001

Dendritic cell vaccines for cancer therapy

  • G.M. Sprinzl

      Affiliations

    • Department of Otorhinolaryngology – Head and Neck Surgery
    • ,
  • L. Kacani

      Affiliations

    • Institute of Hygiene and Social Medicine
    • ,
  • A. Schrott-Fischer

      Affiliations

    • Department of Otorhinolaryngology – Head and Neck Surgery
    • ,
  • N. Romani

      Affiliations

    • Department of Dermatology, University of Innsbruck, Austria
    • ,
  • W.F. Thumfart

      Affiliations

    • Department of Otorhinolaryngology – Head and Neck Surgery

Abstract 

Dendritic cells (DC) are professional antigen-presenting cells whose primary function is the initiation of immune response. Based on the finding that the immune system usually fails to identify and kill cancer cells, DC have been recently used as vaccines for stimulation of tumour-specific immunity. This review focuses on pitfalls related to DC-based vaccination against solid tumours and on improvement of this immunotherapeutic approach for routine treatment of cancer disease.

Keywords: Dendritic cells, vaccination, cancer therapy, immunotherapy, tumour-specific vaccine, immunologic adjuvants.

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PII: S0305-7372(01)90221-X

doi:10.1053/ctrv.2001.0221

Cancer Treatment Reviews
Volume 27, Issue 4 , Pages 247-255, August 2001

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