« Previous
Next »
Cancer Treatment Reviews
Volume 26, Issue 5
, Pages 377-391
, October 2000
Treatment-related leukaemia—a clinical and scientific challenge
References
- REFERENCES
- . Incidence of acute non-lymphocytic leukemia, pre-leukemia and acute myeloproliferative syndrome up to 10 years after treatment of Hodgkin’s disease. N Engl J Med. 1982;307:965–971
- . Second acute leukemia and other malignancies following treatment for Hodgkin’s disease. J Clin Oncol. 1986;4:830–837
- . Risk of second cancers after treatment for Hodgkin’s disease. N Engl J Med. 1988;318:76–81
- . Second malignant neoplasms following childhood Hodgkin’s disease: treatment and splenectonmy as risk factors. Med Pediatr Oncol. 1989;17:477–484
- . Leukemia following Hodgkin’s disease. N Engl J Med. 1990;322:7–13
- . High frequency of etoposide (VP16) related secondary leukemia in children with non-Hodgkin’s lymphoma. Am J Pediatr Hematol Oncol. 1993;15:99–104
- . Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. N Engl J Med. 1989;321:136–142
-
.
Secondary acute myeloid leukemia in children treated for acute lymphoblastic leukemia.
Blood. 1998;92:83a
-
.
Etoposide and Langerhans cells histiocytosis; second malignancies, a second look.
Ped Hematol Oncol. 1999;16:183–185
- . Neuroblastoma and treatment-related myelodysplasia/leukemia: the Memorial Sloan-Kettering experience and a literature review. J Clin Oncol. 1998;16:3880–3889
- . Secondary leukemia following successful treatment of Wilms’ tumour. Am J Pediatr Hematol Oncol. 1989;11:158–161
-
.
Acute myeloid leukemia in patients treated for rhabdomyosarcoma with cyclophosphamide and low-dose etoposide on Intergroup Rhabdomyosarcoma Study 3: an interim report.
Med Ped Oncol. 1994;23:99–106
-
.
Therapy-related acute myeloid leukemia with t(8;21) in a child with previous Ewing’s sarcoma.
Med Ped Oncol. 1997;29:132–134
- . High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumours. J Clin Oncol. 1998;16:3016–3020
- . Myelodysplastic syndrome and acute myeloid leukemia after treatment for solid tumours of childhood. Am J Clin Pathol. 1993;100:270–275
- . Increased risk of myelodysplasia and leukemia after etoposide, cisplatin and bleomycin for germ cell tumours. Lancet. 1991;338:359–363
- . Acute myelogenous leukemia after treatment for malignant germ cell tumours in children. J Clin Oncol. 1999;17:3226–3233
- . Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumours. J Clin Oncol. 1998;16:3386–3391
- . Secondary tumours following etoposide containing therapy for germ cell cancer. Ann Oncol. 1995;6:35–40
- . Implication of prior treatment with drug combinations including inhibitors of topoisomerase 2 in therapy-related monocytic leukemia with a 9;11 translocation. Genes Chromosomes Cancer. 1990;2:53–58
- . Epipodophyllotoxins, alkylating agents and radiation and risk of secondary leukaemia after childhood cancer. BMJ. 1992;304:951–958
-
.
Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: estimating the risk.
Med Ped Oncol. 1994;23:86–98
-
.
Leukemia after therapy with alkylating agents for childhood cancer.
J Natl Cancer Instl. 1987;78:459–464
-
.
Report of the cancer therapy evaluation program monitoring plan for secondary acute myeloid leukemia following treatment with epipodophyllotoxins.
J Natl Cancer Instl. 1993;85:554–558
- . Incidence of secondary acute myelogenous leukemia after treatment of childhood acute lymphoblastic leukemia. Cancer. 1992;70:2208–2213
-
.
The secondary leukemias: challenges and research directions.
J Natl Cancer Instl. 1996;88:407–418
- . Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med. 1991;325:1682–1687
- . Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases. Leukemia. 1995;9:1990–1996
-
.
Therapy-related myeloid leukemia.
Hematology/Oncology Clinics North Am. 1996;10:293–320
- . Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide. J Clin Oncol. 1993;11:209–217
-
.
Therapy-related myelodysplastic syndromes.
Sem Hematol. 1996;33:256–273
- . Melphalan may be a more potent leukemogen than cyclophosphamide. Ann Intern Med. 1986;105:360–367
- . Mutagenic damage to mammalian cells by therapeutic alkylating agents. Mutat Res. 1996;355:41–57
- . Critical steps in alkylation-induced aberration formation. Mutat Res. 1998;404:119–124
-
.
Molecular Biology for Oncologist, 2nd Edn. London: Chapman and Hall,; 1996;
-
.
Molecular aspects of cellular responses to radiotherapy.
Radiotherapy Oncology. 1997;44:1–7
- . Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation. Cancer Res. 1998;58:421–425
- . L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins. Leukemia. 1995;9:1680–1684
- . Epipodophyllotoxin-related leukemia. Cancer. 1991;68:600–604
- . Secondary leukemias induced by topoisomerase-targeted drugs. Biochimica et Biophysica Acta. 1998;1400:233–255
- . ALL-1 gene rearrangement in DNA topoisomerase 2 inhibitor-related leukemia in children. Blood. 1995;85:3250–3256
- . Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase 2. Blood. 1991;78:1147–1148
- . Therapy-related acute myeloid leukemia with t(8;21), inv(16) and t(8;16): a report on 25 cases and review of the literature. J Clin Oncol. 1993;11:2370–2379
- . Type 2 DNA-topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell. 1980;19:697–707
- . A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase 2. A two-site model for enzyme-mediated DNA cleavage. J Biol Chem. 1992;267:683–686
- . Recent developments in DNA topoisomerase 2 structure and mechanism. Curr Opin Struct Biol. 1996;6:84–90
-
.
Structural similarities between topoisomerases that cleave one or both DNA strands.
Proc Natl Acad Sci USA. 1998;95:7876–7881
- . Drug-induced DNA damage and tumour chemosensitivity. J Clin Oncol. 1990;8:2062–2084
-
.
Mechanism of action of antitumour drug etoposide: a review.
J Natl Cancer Instl. 1998;80:1526–1533
-
.
Etoposide (VP-16–213) induced gene alterations: potential contribution to cell death.
Proc Natl Acad Sci USA. 1991;88:8740–8743
- . Differential effects of amsacrine and epipodophyllotoxins on topoisomerase 2 cleavage in the human c-myc protooncogene. Cancer Res. 1992;52:3125–3130
- . DNA topoisomerase 2-trapping antitumour drugs. Eur J Cancer. 1992;28A:2055–2060
- . An MLL–AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogene. Cell. 1996;85:853–861
- . Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally-transduced HRX-ENL. EMBO J. 1997;16:4226–4237
- . Potential role for wild type p53 in leukemias with MLL gene translocations. Oncogene. 1998;16:1351–1356
- . The p53 gene in pediatric therapy-related leukemia and myelodysplasia. Blood. 1996;87:4376–4381
- . Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases. Blood. 1985;65:1364–1372
- . Secondary leukemias associated with neoplasia: treated and untreated. Cancer Genet Cytogenet. 1984;11:319–321
- . Banded chromosome analysis in patients with treatment-associated acute non-lymphocytic leukemia. Cancer Genet Cytogenet. 1984;12:189–199
- . Therapy-related myelodysplastic syndrome and acute myeloid leukemia in children: correlation between chromosomal abnormalities and prior therapy. Blood. 1991;78:2982–2988
- . Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic syndrome after different treatment modalities. Blood. 1998;71:403–414
- . Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute non-lymphocytic leukemia. Blood. 1990;76:1083–1091
- . Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia. Blood. 1995;86:3542–3552
-
.
Cytogenetic and molecular analysis of therapy-related leukemia.
Annals N Y Acad Sci. 1989;567:130–140
-
.
The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q.
Proc Natl Acad Sci USA. 1987;84:5913–5917
- . Interleukin 4 and interleukin 5 map to human chromosome 5 in a region, encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q). Blood. 1989;73:647–650
- . Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Blood. 1996;88:1930–1935
- . Childhood monosomy 7: epidemiology, biology and mechanistic implications. Blood. 1995;85:1985–1999
- . RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study. Genes Chromosomes Cancer. 1990;2:159–162
-
.
Analysis of RAS gene mutations in childhood myeloid leukemia.
BJH. 1991;77:323–327
-
.
RAS oncogene activation and occupational exposures in acute myeloid leukemia.
J Natl Cancer Instl. 1992;84:1626–1632
-
.
Activating RAS mutations in therapy-related myeloid disorders associated with deletions of chromosomes 5 and 7.
Blood. 1996;88:566a-[abstract]
- . The role of RAS in signal transduction. Biochem Soc Trans. 1991;19:296–299
-
.
Acute lymphoblastic leukemia with t(4;11) follows neuroblastoma: a late effect of treatment?.
Med Ped Oncol. 1985;13:48–50
- . Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non small-cell carcinoma of the lung. Blood. 1987;70:1412–1417
-
.
Fourth International Workshop on chromosomes in leukemia: rearrangement of 11q.
Cancer Genet Cytogenet. 1982;11:294–295
- . 11q23 abnormalities in children with acute non-lymphocytic leukemia (M4–M5). Association with previous chemotherapy. Cancer Genet Cytogenet. 1990;45:1–11
- . 11q23 rearrangements in acute leukemia. Leukemia. 1996;10:74–82
- . Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. Gene Chromosome Cancer. 1995;13:75–85
- . Rearrangement of the MLL gene in acute lymphoblastic and myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med. 1993;329:909–914
- . HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities. Blood. 1993;81:3197–3203
- . Rearrangement of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase 2. Blood. 1993;82:3705–3711
-
.
Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias.
Proc Natl Acad Sci USA. 1997;94:11583–11588
- . Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia. Cancer Res. 1993;53:2954–2956
-
.
MLL rearrangements in haematological malignancies: lessons from clinical and biological studies.
BJH. 1999;106:614–626
- . Complete exon structure of the ALL-1 gene. Cancer Res. 1996;56:1766–1769
- . The human MLL gene: nucleotide sequence, homology to the Drosophila TRX Zinc-finger domains and alternative splicing. DNA and cell Biology. 1995;14:475–483
- . MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children. J Pediatr Hematol Oncol. 1998;20:299–308
-
.
Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.
Proc Natl Acad Sci USA. 1993;90:8538–8542
- . Chromosome 11q23 translocations in both infant and adult leukemias are detected by in situ hybridization with a yeast artificial chromosome. Blood. 1992;80:1659–1665
- . Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age. Blood. 1996;87:2870–2877
- . Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase 2 consensus binding sites. Blood. 1996;87:1912–1922
- . A consensus sequence for cleavage by vertebrate DNA topoisomerase 2. Nucleic Acid Res. 1988;16:5533–5556
- . Molecular analysis of 13 cases of MLL /11q23 secondary acute leukemia and identification of topoisomerase 2 consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with t(4;11). Leukemia. 1995;9:1305–1312
- . An in vivo topoisomerase 2 cleavage site and a DNase 1 hypersensitive site colocalise near exon 9 in theMLL breakpoint cluster region. Blood. 1998;92:3793–3803
- . Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase 2 inhibitors. Blood. 1996;87:2649–2658
-
.
Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.
Cancer Res. 1994;54:2327–2330
- . Infant acute leukemias show the same biased distribution of ALL-1 gene breaks as topoiomerase 2 related secondary acute leukemias. Cancer Res. 1997;57:2879–2883
- . Maternal exposure to potential inhibitors of DNA topoisomerase 2 and infant leukemia (US): a report from the Children’s Cancer Group. Cancer Causes Control. 1996;7:581–590
- . Leukemia in infants. Oncologist. 1999;4:225–240
- . Chromosome band 11q23 translocation breakpoints are DNA topoisomerase 2 cleavage sites. Cancer Res. 1995;55:4287–4292
- . Molecular analysis of t(11;19) breakpoints in childhood acute leukemias. Blood. 1996;87:4804–4808
-
.
Genes on chromosomes 4, 9 and 19 involved in 11q23 abnormalities in acute leukemias share sequence homology and/or common motifs.
Proc Natl Acad Sci USA. 1993;90:4631–4635
- . A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature haematopoietic cells. Blood. 1995;85:650–656
- . AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. Blood. 1997;90:3714–3719
- . Adenoviral EIA-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). Blood. 1997;90:4699–4704
-
.
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
Proc Natl Acad Sci USA. 1997;94:8732–8737
- . The der(11) chromosome contains the critical breakpoint junction in the 4;11, 9;11 and 11;19 translocations in acute leukemia. Genes Chromosome Cancer. 1992;5:264–266
- . CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy. Blood. 1998;92:2879–2885
- . Topoisomerase 2 inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus. Leukemia. 1997;11:490–496
-
.
The AML-ETO transcription factor in acute myeloid leukemia: biology and clinical significance.
BJH. 1999;106:296–308
- . Translocation (3;21)(q26;q22) in therapy-related myelodysplasia following drugs targeting DNA topoisomerase 2 combined with alkylating agents and in myeloproliferative disorders undergoing spontaneous leukemic transformation. Cancer Genet Cytogenet. 1994;76:50–55
- . Phase 2 study of 21 day schedule oral etoposide in children. New Agent Group of the UKCCSG. Eur J Cancer. 1997;33:1816–1822
- . Therapy-related leukemia and myelodysplasia following oral administration of etoposide for recurrent breast cancer. Int J Oncol. 1998;13:91–96
-
.
Secondary leukaemia in a child with neuroblastoma whilst on oral etoposide- what is the cause?.
Pediatric Hematology Oncology. 2000;17:273–279
-
.
Acute promyelocytic leukemia with t(15;17) following treatment of Hodgkin’s disease- a report of 4 cases.
Annals Oncol. 1995;6:777–779
- . Therapy-related acute promyelocytic leukemia: a report of 16 cases. J Clin Oncol. 1992;10:1430–1435
-
.
Molecular analysis of the t(15;17) translocation in de novo and secondary acute promyelocytic leukemia.
Leukemia. 1997;11:287–288
- . Molecular genetics of childhood leukemias. J Pediatr Hematol Oncol. 1998;20:1–11
- . Specific chromosomal translocations and therapy-related leukemia induced by bimolane therapy for psoriasis. Leuk Res. 1992;16:1113–1223
- . Inversion of chromosome 16 and uncommon rearrangements of the CBFB and MYH11 genes in therapy-related acute myeloid leukemia: rare events related DNA topoisomerase 2 inhibitors?. J Clin Oncol. 1998;16:1890–1896
- . All patients with the t(11;16)(q23;q13.3) that involves MLL and CBP have treatment-related hematologic disorders. Blood. 1997;90:535–541
- . The translocation t(8;160(p11;p13) of acute myeloid leukemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet. 1996;14:33–41
- . Chemotherapy-related and late-occurring Philadelphia chromosome in AML, ALL and CML. Similar events related to treatment with DNA topoisomerase 2 inhibitors?. Leukemia. 1997;11:1571–1574
- . The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results inNUP98-TOP1 fusion. Blood. 1999;94:3258–3261
- . The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. Int J Hematol. 1998;69:160–164
- . Therapy-related myelodysplastic syndrome and acute myeloid leukemia with 17p deletion. A report on 25 cases. Leukemia. 1999;13:250–257
- . Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood. 1996;88:4296–4303
- . Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated with hydroxyurea: high proportion cases with 17p deletion. Blood. 1998;91:616–622
- . Acute lymphoblastic leukemia occurring as a second malignant neoplasm in childhood: Report of 3 cases and review of literature. J Clin Oncol. 1992;10:156–163
- . Second primary neoplasms in patients with retinoblastoma. Br J Cancer. 1986;53:661–671
- . Genes and cancer. Arch Dis Child. 1999;80:1–3
- . Li-Fraumeni syndrome- a molecular and clinical review. Br J Cancer. 1997;76:1–14
- . Association of germ-line p53 mutation with MLL segmental jumping translocation in treatment-related leukemia. Blood. 1998;91:4451–4456
- . Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences. Gene Chromosome Cancer. 1999;24:295–298
- . Frequent jumping translocations of chromosomal segments involving the ABL oncogene alone or in combination withCD3–MLL genes in secondary leukemias. Blood. 1997;89:596–600
- . Monosomy 7 syndrome and other secondary neoplasms in children with NF1. Cancer. 1997;79:1438–1446
- . Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility—a review. Gene. 1995;159:113–121
- . Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta (GSTT1) gene defect. Lancet. 1996;347:295–297
-
.
Association of CYP3A4 genotype with treatment-related leukemia.
Proc Natal Acad Sci USA. 1998;95:13176–13181
- . Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia. 1998;12:346–352
- . Prevalence of the inactivating609C T → polymorphism in the NAD(P)H: Quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia. Blood. 1999;94:803–807
- . Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells. Cancer. 1999;86:1080–1086
-
.
Polymorphisms in the MLL breakpoint cluster region may predispose patients to translocations following anti-topo 2 therapy.
Blood. 1999;94 (Suppl. 1):692a
- . Treatment of children with epipodophyllotoxin-induced secondary acute myeloid leukemia. Cancer. 1997;79:1049–1054
- . Stem cell transplantation for secondary acute myeloid leukemia: Evaluation of transplantation as initial therapy or following induction chemotherapy. Blood. 1997;89:2578–2585
- . Bone marrow transplantation in pediatric patients with therapy-related myelodysplasia and leukemia. Bone Marrow Transplantation. 1999;23:21–25
- . Clinical and cytogenetic responses to granulocyte-macrophage colony-stimulating factor in therapy-related myelodysplasia. Blood. 1992;80:2463–2470
PII: S0305-7372(00)90186-5
doi: 10.1053/ctrv.2000.0186
« Previous
Next »
Cancer Treatment Reviews
Volume 26, Issue 5
, Pages 377-391
, October 2000
