Cancer Treatment Reviews
Volume 26, Issue 5 , Pages 333-350, October 2000

Antisense therapy in cancer

Department of Oncology, Central Clinical Hospital of Military Medical Academy, Warsaw, Poland

Abstract 

This review discusser laboratory and clinical studies of antisense oligodeoxynucleotides as potential treatments for haematological malignancies and solid tumours. Mechanisms of action, pharmacokinetics, toxicities and potential clinical applications of these agents are described.

Keywords: Antisense, oligonucleotides, oligodeoxynucloetides, phosphorothioate, ODNs, PTAOs.

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PII: S0305-7372(00)90173-7

doi:10.1053/ctrv.2000.0173

Cancer Treatment Reviews
Volume 26, Issue 5 , Pages 333-350, October 2000

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