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Uveal melanoma
24 January 2012
Francesco Spagnolo, Graziano Caltabiano, Paola Queirolo
Abstract: Uveal melanoma, which arises from melanocytes residing in the stroma, is the most common primary intraocular tumor in adults. Up to 50% of patients with primary uveal melanoma will ultimatel...
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A preclinical and clinical review of aflibercept for the management of cancer
24 January 2012
Andrew Gaya, Vivien Tse
Abstract: Aflibercept, also known as vascular endothelial growth factor (VEGF)–Trap, is a recombinant, decoy receptor fusion protein, rationally designed to block angiogenesis by targeting not only al...
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State-of-the-art classification and multimodality treatment of malignant thymoma
16 January 2012
Hannah Koppitz, Jürgen K. Rockstroh, Heinrich Schüller, Jens Standop, Dirk Skowasch, Hans Konrad Müller-Hermelink, Ingo G.H. Schmidt-Wolf
Abstract: Thymomas are the most common tumors of the anterior mediastinum. Classification, treatment options and understanding of the pathophysiology of thymoma have changed over the past years. It is...
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Impact of bortezomib on bone health in myeloma: A review of current evidence
09 January 2012
Maurizio Zangari, Evangelos Terpos, Fenghuang Zhan, Guido Tricot
Abstract: Bone disease is a key feature in multiple myeloma (MM) and can have a substantial impact on patient morbidity and quality-of-life. The pathogenesis of lytic bone disease in MM is complex and...
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Adjuvant immunotherapy for non-small cell lung cancer
09 January 2012
Zachary C.G. Tucker, Benjamin A. Laguna, Edmund Moon, Sunil Singhal
Abstract: Non-small cell lung cancer (NSCLC) is the biggest cancer killer in the United States and worldwide. In 2011, there are estimated to be 221,130 new cases of lung cancer in the United States. ...
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